Perceptual Unit Formation in Infancy

Author(s):  
Martha E. Arterberry
Blood ◽  
2002 ◽  
Vol 99 (12) ◽  
pp. 4400-4405 ◽  
Author(s):  
Suzanne Burns ◽  
Murat O. Arcasoy ◽  
Li Li ◽  
Elizabeth Kurian ◽  
Katri Selander ◽  
...  

A drug that specifically inhibits erythropoiesis would be clinically useful. The erythropoietin (Epo) mutant Epo (R103A) could potentially be used for this purpose. Epo (R103A) has a single amino acid substitution of alanine for arginine at position 103. Because of this mutation, Epo (R103A) is only able to bind to one of the 2 subunits of the erythropoietin receptor (EpoR) homodimer and is thus a competitive inhibitor of Epo activity. To produce large quantities of Epo (R103A) to test in animal models of thalassemia and sickle cell disease, we expressed and purified recombinant Epo (R103A) from the yeast Pichia pastoris. Using this method milligram quantities of highly purified Epo (R103A) are obtained. The yeast-expressed Epo (R103A) is properly processed and glycosylated and specifically inhibits Epo-dependent cell growth and125I-Epo binding. Epo (R103A) does not, however, directly induce apoptosis in 32D cells expressing EpoR. Epo (R103A) inhibits erythropoiesis of human CD34+ hematopoietic cells and completely blocks erythroid burst-forming unit formation in normal human bone marrow colony assays. Yeast-expressed Epo (R103A) is a specific inhibitor of primary erythropoiesis suitable for testing in animal models.


2021 ◽  
Author(s):  
Joseph Nah ◽  
Joy Geng

While objects are fundamental units of vision that convey meaning, how different types of semantic knowledge affect perception is not fully understood. In contrast, the concept literature divides semantic information into taxonomic and thematic types. Taxonomic relationships reflect categorization by similarities (e.g., dog – wolf); thematic groups are based on complementary relationships shared within a common event (e.g., swimsuit – goggles; pool). A critical difference between these two information types is that thematic relationships are learned from the experienced co-occurrence of objects whereas taxonomic relationships are learned abstractly. In two studies, we test the hypothesis that visual processing of thematically related objects is more rapid because they serve as mutual visual primes and form a perceptual unit. The results demonstrate that learned co-occurrence not only shapes semantic knowledge, but also affects low level visual processing, revealing a link between how information is acquired (e.g., experienced vs. unobserved) and how it modulates perception.


2019 ◽  
pp. 127-153
Author(s):  
Kevin Connolly

This chapter argues that multisensory perceptions are learned, not the result of an automatic feature binding mechanism. For example, suppose you are at a live jazz show. The drummer begins a solo. You see the cymbal jolt and hear the clang. But you are also aware that the jolt and the clang are part of the same event. Psychologists have assumed that multisensory perceptions like this one are the result of an automatic feature binding mechanism. This chapter argues instead that when you experience the jolt and the clang as part of the same event, it is the result of a perceptual learning process. The jolt and the clang are best understood as a single learned perceptual unit, not as automatically bound. This chapter details the perceptual learning process of “unitization,” whereby we come to “chunk” the world into multisensory units, and argues that unitization best explains multisensory perception.


2006 ◽  
Vol 59 (3) ◽  
pp. 543-556 ◽  
Author(s):  
Poppy A. C. Crum ◽  
Albert S. Bregman
Keyword(s):  

2015 ◽  
Vol 44 (8) ◽  
pp. 3724-3727 ◽  
Author(s):  
Richa Rakshit ◽  
Samir Ghorai ◽  
Amrit Sarmah ◽  
Archana Tiwari ◽  
Ram Kinkar Roy ◽  
...  

Ligand H2Rich(AP)N3 provided a diradical-containing Co(ii) complex via an inter-ligand azo (NN) bond formation.


1998 ◽  
Vol 21 (6) ◽  
pp. 772-772
Author(s):  
Thomas F. Shipley

Findings in dynamic unit formation suggest that completion processes reflect the optics of our world. Dynamic unit formation may depend on patterns of motion signals that are consistent with the causes of optical changes. In addition, dynamic completion conforms to a local curvature minimization constraint. Such relational aspects of vision are important to consider in linking perceptual experience and neural activity.


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