Two antiestrogens affect differently chromatin remodeling of trefoil factor 1 (pS2) gene and the fate of estrogen receptor in MCF7 cells

2002 ◽  
Vol 1578 (1-3) ◽  
pp. 12-20 ◽  
Author(s):  
Claire Giamarchi ◽  
Catherine Chailleux ◽  
Mathide Calligé ◽  
Philippe Rochaix ◽  
Didier Trouche ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Chromatin Remodeling ◽  
Trefoil Factor ◽  
Mcf7 Cells ◽  
Trefoil Factor 1

Estrogen regulation of trefoil factor 1 expression by estrogen receptor α and Sp proteins

2005 ◽  
Vol 302 (1) ◽  
pp. 96-107 ◽  
Author(s):  
Jian-Min Sun ◽  
Virginia A. Spencer ◽  
Lin Li ◽  
Hou Yu Chen ◽  
Jenny Yu ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Estrogen Receptor Α ◽  
Trefoil Factor ◽  
Estrogen Regulation ◽  
Trefoil Factor 1

Trefoil factor-1 upregulation in estrogen-receptor positive breast cancer correlates with an increased risk of bone metastasis

Bone ◽  
2021 ◽  
Vol 144 ◽  
pp. 115775
Author(s):  
Chiara Spadazzi ◽  
Laura Mercatali ◽  
Mark Esposito ◽  
Yong Wei ◽  
Chiara Liverani ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Bone Metastasis ◽  
Trefoil Factor ◽  
Increased Risk ◽  
Estrogen Receptor Positive ◽  
Trefoil Factor 1 ◽  
Positive Breast Cancer

scholarly journals Transcriptome analysis and connectivity mapping of Cissampelos pareira L. provides molecular links of ESR1 modulation to viral inhibition

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Madiha Haider ◽  
Dhwani Dholakia ◽  
Aleksha Panwar ◽  
Parth Garg ◽  
Atish Gheware ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Mcf7 Cell ◽  
Estrogen Receptor Α ◽  
Viral Inhibition ◽  
Mcf7 Cells ◽  
Docking Analysis ◽  
Female Hormone ◽  
Herbal Formulation ◽  
Estrogen Response ◽  
Estrogen Receptor 1

AbstractBioactive fractions obtained from medicinal plants which have been used for the treatment of multiple diseases could exert their effects by targeting common pathways. Prior knowledge of their usage could allow us to identify novel molecular links. In this study, we explored the molecular basis of action of one such herbal formulation Cissampelos pareira L. (Cipa), used for the treatment of female hormone disorders and fever. Transcriptomic studies on MCF7 cell lines treated with Cipa extract carried out using Affymetrix arrays revealed a downregulation of signatures of estrogen response potentially modulated through estrogen receptor α (ERα). Molecular docking analysis identified 38 Cipa constituents that potentially bind (ΔG <  − 7.5) with ERα at the same site as estrogen. The expression signatures in the connectivity map (https://clue.io/;) revealed high positive scores with translation inhibitors such as emetine (score: 99.61) and knockdown signatures of genes linked to the antiviral response such as ribosomal protein RPL7 (score: 99.92), which is a reported ERα coactivator. Further, gene knockdown experiments revealed that Cipa exhibits antiviral activity in dengue infected MCF7 cells potentially modulated through estrogen receptor 1. This approach reveals a novel pathway involving the ESR1-RPL7 axis which could be a potential target in dengue viral infection.

scholarly journals TreFoil Factor 1 (TFF1/pS2) Deficiency Activates the Unfolded Protein Response

2002 ◽  
Vol 8 (5) ◽  
pp. 273-282 ◽  
Author(s):  
Luis-Fernando Torres ◽  
Sherif M. Karam ◽  
Corinne Wendling ◽  
Marie-Pierre Chenard ◽  
David Kershenobich ◽  
...  
Keyword(s):  
Unfolded Protein Response ◽  
Trefoil Factor ◽  
Unfolded Protein ◽  
The Unfolded Protein Response ◽  
Protein Response ◽  
Trefoil Factor 1
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