P320 The effects of traditional drug Qiliqiangxin on inflammatory cytokines expression in rats with acute myocardial infarction

2008 ◽  
Vol 125 ◽  
pp. S56-S57 ◽  
Author(s):  
X. Cheng ◽  
Y. Song ◽  
Y.H. Liao ◽  
Y. Li ◽  
J. Yuan
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Inflammatory Cytokines ◽  
Traditional Drug

scholarly journals Are Inflammatory Cytokines Associated with Pain during Acute Myocardial Infarction?

2017 ◽  
Vol 24 (3) ◽  
pp. 154-161 ◽  
Author(s):  
Laurin Imholz ◽  
Rebecca E. Meister-Langraf ◽  
Mary Princip ◽  
Michaela Fux ◽  
Ulrich Schnyder ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Inflammatory Cytokines

Role of Pro-/Anti-Inflammatory Cytokines and their Correlation with Established Risk Factors in South Indians with Coronary Artery Disease

Angiology ◽  
2008 ◽  
Vol 60 (4) ◽  
pp. 419-426 ◽  
Author(s):  
Medha Rajappa ◽  
S. K. Sen ◽  
Alpana Sharma
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Acute Myocardial Infarction ◽  
Coronary Artery ◽  
Unstable Angina ◽  
Inflammatory Cytokines ◽  
Tumor Necrosis ◽  
Interleukin 10 ◽  
Anti Inflammatory ◽  
Artery Disease

Cytokines are responsible for the modulation of immunological and inflammatory processes and play a significant role in the pathogenesis of coronary artery disease. We estimated the levels of pro-/anti-inflammatory cytokines in South Indian patients with coronary artery disease. The study population comprised of groups 1–3: 100 patients each with acute myocardial infarction, unstable angina, and stable angina, respectively, and group 4 (100 healthy controls). Cytokine levels (interleukin-6, interleukin-8, interleukin-10, and tumor necrosis factor-α) were estimated by enzyme-linked immunosorbent assay (ELISA). Interleukin-6, interleukin-8, and tumor necrosis factor-α levels were significantly higher in patients from groups 1 and 2, than in group 3 and controls. Acute myocardial infarction patients exhibited higher serum levels of interleukin-10 compared with other groups and control subjects. Patients with unstable angina had significantly lower interleukin-10 concentrations than those with stable angina. The ratios of pro-/anti-inflammatory cytokines in all the study groups increased significantly when patients with unstable angina were compared to other groups. In patients with acute myocardial infarction, interleukin-10 and tumor necrosis factor-α levels showed significant correlation with established risk factors such as body mass index, blood pressure, and lipid levels. Acute myocardial infarction patients show elevation in proinflammatory and anti-inflammatory cytokines, while unstable angina is associated with low levels of serum interleukin-10. Higher levels of antiinflammatory cytokine interleukin-10 may be needed to provide protection in unstable angina. These cytokines are markers of coronary artery disease and may be used for the identification of high-risk patients with unstable angina/acute myocardial infarction.

The relationships among monocyte subsets, miRNAs and inflammatory cytokines in patients with acute myocardial infarction

2019 ◽  
Vol 71 (1) ◽  
pp. 73-81
Author(s):  
Ewelina Kazimierczyk ◽  
Andrzej Eljaszewicz ◽  
Paula Zembko ◽  
Ewa Tarasiuk ◽  
Malgorzata Rusak ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Inflammatory Cytokines ◽  
Monocyte Subsets

Association of influenza virus infection and inflammatory cytokines with acute myocardial infarction

2012 ◽  
Vol 61 (6) ◽  
pp. 591-598 ◽  
Author(s):  
Xiuru Guan ◽  
Wei Yang ◽  
Xijuan Sun ◽  
Lanfeng Wang ◽  
Benjiang Ma ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Influenza Virus ◽  
Virus Infection ◽  
Inflammatory Cytokines ◽  
Influenza Virus Infection

scholarly journals Assessment of regulatory/effector T cell balance along with pro/anti-inflammatory cytokines level in acute myocardial infarction

2014 ◽  
Vol 66 ◽  
pp. S17
Author(s):  
Saibal Mukhopadhyay ◽  
Hariram Maharia ◽  
Jamal Yusuf ◽  
Vimal Mehta ◽  
Vijay Trehan ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
T Cell ◽  
Inflammatory Cytokines ◽  
Effector T Cell ◽  
Anti Inflammatory ◽  
Cell Balance

scholarly journals Effect of Tirofiban Injection on vascular endothelial function, cardiac function and inflammatory cytokines in patients with acute myocardial infarction after emergency Percutaneous Coronary Intervention

2021 ◽  
Vol 38 (1) ◽  
Author(s):  
Shi-xin Kang ◽  
Xiao-min Meng ◽  
Jing Li
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Endothelial Function ◽  
Cardiac Function ◽  
Inflammatory Cytokines ◽  
Control Group ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function ◽  
Significant Difference ◽  
Experimental Group

Objectives: To evaluate the effect of tirofiban injection on vascular endothelial function, cardiac function, inflammatory cytokines and other indicators in patients with acute myocardial infarction after emergency PCI and its clinical significance. Methods: Eighty patients with acute myocardial infarction admitted to Affiliated Hospital of Hebei University from March 18, 2020 to October 18, 2020 were enrolled and randomly divided into two groups: the experimental group and the control group, with 40 cases in each group. Patients in both groups underwent PCI. Patients in the control group were given oxygen inhalation, monitoring, and basic medications for myocardial infarction, such as nutritional myocardial drugs, statins, aspirin, nitrates, clopidogrel, and β-blockers. In contrast, patients in the experimental group received tirofiban 10 ug/kg intravenously over 5min immediately before PCI in addition to basic treatment, and then tirofiban 0.1 ug/(kg/min) was pumped via intravenous pump postoperatively for 48 hour. The changes of vascular endothelial function, cardiac function and adverse drug reactions (ADRs) in the two groups before treatment, one week and one month after treatment, as well as changes of inflammatory cytokines such as CRP and IL-6 in the two groups before and after treatment were compared and analyzed. Results: Compared with the control group, FMD, NO, ET-1 and other indexes in the experimental group were significantly improved one week and one month after treatment, with statistically significant differences (p<0.05). BNP, LVEDD, LVEF and additional indexes in the experimental group were significantly lower than those in the control group at one week and one month after treatment, with statistically significant differences (p=0.00). Moreover, the incidence of ST-segment fallback > 70% in the experimental group was 72.5% after treatment, which was significantly better than that of 47.5% in the control group, with a statistically significant difference (p=0.03). CRP and IL-6 in the experimental group were significantly lower than those in the control group after treatment, with a statistically significant difference (p=0.00). There was no statistical significance in the incidence of ADRs between the two groups after treatment (p=0.42). Conclusion: Tirofiban injection after emergency PCI is a beneficial treatment regime for patients with STEMI. With such a treatment regime, cardiac function and vascular endothelial function of patients can be dramatically improved, coronary blood supply will be ameliorated, inflammatory cytokines can be reduced, and no significant increase can be seen in the incidence of adverse reactions. doi: https://doi.org/10.12669/pjms.38.1.4413 How to cite this:Kang S, Meng X, Li J. Effect of Tirofiban Injection on vascular endothelial function, cardiac function and inflammatory cytokines in patients with acute myocardial infarction after emergency Percutaneous Coronary Intervention. Pak J Med Sci. 2022;38(1):---------. doi: https://doi.org/10.12669/pjms.38.1.4413 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Targeting TLR4 with ApTOLL Improves Heart Function in Response to Coronary Ischemia Reperfusion in Pigs Undergoing Acute Myocardial Infarction

Biomolecules ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 1167 ◽  
Author(s):  
Rafael Ramirez-Carracedo ◽  
Laura Tesoro ◽  
Ignacio Hernandez ◽  
Javier Diez-Mata ◽  
David Piñeiro ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Inflammatory Cytokines ◽  
Heart Function ◽  
Ischemia Reperfusion ◽  
Triphenyltetrazolium Chloride ◽  
Gm Csf ◽  
Tissue Integrity ◽  
Coronary Ischemia ◽  
Masson Trichrome Staining

Toll-like receptor 4 (TLR4) contributes to the pathogenesis of coronary ischemia/reperfusion (IR). To test whether the new TLR4 antagonist, ApTOLL, may prevent coronary IR damage, we administered 0.078 mg/kg ApTOLL or Placebo in pigs subjected to IR, analyzing the levels of cardiac troponins, matrix metalloproteinases, pro-, and anti-inflammatory cytokines, heart function, and tissue integrity over a period of 7 days after IR. Our results show that ApTOLL reduced cardiac troponin-1 24 h after administration, improving heart function, as detected by a significant recovery of the left ventricle ejection fraction (LVEF) and the shortening fraction (FS) cardiac parameters. The extension of necrotic and fibrotic areas was also reduced, as detected by Evans blue/2,3,5-triphenyltetrazolium chloride (TTC) staining, Hematoxylin/Eosine, and Masson Trichrome staining of heart sections, together with a significant reduction in the expression of the extracellular matrix-degrading, matrix metalloproteinase 9. Finally, the expression of the following cytokines, CCL1, CCL2, MIP1-A-B, CCL5, CD40L, C5/C5A, CXCL1, CXCL10, CXCL11, CXCL12, G-CSF, GM-CSF, ICAM-1, INF-g, IL1-a, ILI-b, IL-1Ra, IL2, IL4, IL5, IL6, IL8, IL10, IL12, IL13, IL16, IL17-A, IL17- E, IL18, IL21, IL27, IL32, MIF, SERPIN-E1, TNF-a, and TREM-1, were also assayed, detecting a pronounced decrease of pro-inflammatory cytokines after 7 days of treatment with ApTOLL. Altogether, our results show that ApTOLL is a promising new tool for the treatment of acute myocardial infarction (AMI).

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