Relation between mutations in the basal core promoter of hepatitis B virus and precore mutations, HBV genotypes and viral replication

2001 ◽  
Vol 34 ◽  
pp. 201
Author(s):  
X. Costa ◽  
R. Jardi ◽  
M. Buti ◽  
F. Rodriguez-Frias ◽  
M. Cotrina ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Viral Replication ◽  
Core Promoter ◽  
Basal Core Promoter ◽  
Hbv Genotypes ◽  
B Virus

Precore and basal core promoter hepatitis B virus (HBV) variants are present from a young age and differ across HBV genotypes

Hepatology ◽  
2020 ◽  
Author(s):  
Daryl T.Y. Lau ◽  
Lilia Ganova‐Raeva ◽  
Junyao Wang ◽  
Douglas Mogul ◽  
Raymond T. Chung ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Core Promoter ◽  
Young Age ◽  
Basal Core Promoter ◽  
Hbv Genotypes ◽  
B Virus ◽  
Hbv Variants

scholarly journals Genotyping Hepatitis B virus from whole- and sub-genomic fragments using position-specific scoring matrices in hbv star

2006 ◽  
Vol 87 (6) ◽  
pp. 1459-1464 ◽  
Author(s):  
Richard Myers ◽  
Caroline Clark ◽  
Arshad Khan ◽  
Paul Kellam ◽  
Richard Tedder
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Core Promoter ◽  
Full Length ◽  
Basal Core Promoter ◽  
Hbv Genotype ◽  
Promoter Sequences ◽  
Hbv Genotypes ◽  
Scoring Matrices ◽  
B Virus

Hepatitis B virus (HBV) genomes have been classified into eight genotypes based on phylogenetic analysis of sequence variation. Identifying and tracking the movement of HBV genotypes is important in terms of both monitoring infection rates and predicting disease and treatment. An HBV genotyping tool has been developed that compares query sequences with position-specific scoring matrices representing the eight HBV genotypes. This tool (hbv star) is rapid, robust and accurate and assigns genotype based on a statistically defined scoring model. hbv star confidently assigned 90 % of 590 full-length HBV genomes to an HBV genotype (Z score >2.0). Thirty-two of the residual 48 sequences were identified as non-human primate viruses and 16 sequences were identified as recombinant or putative recombinants. Receiver-Operated Characteristic (ROC) analysis was used to compare the accuracy of genotype prediction using basal core promoter sequences and surface and core genes with the accuracy achieved by using full-length sequences. A web interface to hbv star is available at http://www.vgb.ucl.ac.uk/starn.shtml.

scholarly journals Hepatitis B virus genotype and mutants and the risk of hepatocellular carcinoma

2011 ◽  
Vol 2 (3) ◽  
pp. 129
Author(s):  
Camillo Porta
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
National Cancer Institute ◽  
Core Promoter ◽  
Basal Core Promoter ◽  
Common Variants ◽  
Virus Genotype ◽  
Hbv Genotypes ◽  
B Virus

In the August issue of the authoritative Journal of the National Cancer Institute, a research group from Taiwan reported the results of a huge study aimed at assessing a possible association between Hepatitis B virus (HBV) genotypes and common variants in the precore and basal core promoter (BP) regions and the risk of hepatocellular carcinoma (HCC)...

scholarly journals Prevalence of Hepatitis B Virus Subgenotypes and Basal Core Promoter, Precore Variants in Patients with Acute Hepatitis B in Central Vietnam

Intervirology ◽  
2009 ◽  
Vol 52 (1) ◽  
pp. 22-28 ◽  
Author(s):  
Kazuhiko Hayashi ◽  
Yoshiaki Katano ◽  
Tran Xuan Chuong ◽  
Yasushi Takeda ◽  
Masatoshi Ishigami ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Acute Hepatitis ◽  
Core Promoter ◽  
Basal Core Promoter ◽  
Central Vietnam ◽  
B Virus ◽  
Acute Hepatitis B

Presence of hepatitis B virus core promoter mutations pre-seroconversion predict persistent viral replication after HBeAg loss

2007 ◽  
Vol 39 (3) ◽  
pp. 199-204 ◽  
Author(s):  
R. Bridget Ferns ◽  
Nikolai V. Naoumov ◽  
Richard J. Gilson ◽  
Richard S. Tedder
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Viral Replication ◽  
Core Promoter ◽  
Virus Core ◽  
B Virus ◽  
Hbeag Loss ◽  
Promoter Mutations
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