[244] CHANGES IN THE PROFILES OF CAUSATIVE AGENTS AND ANTIBIOTIC RESISTANCE RATE FOR SPONTANEOUS BACTERIAL PERITONITIS: AN ANALYSIS OF CULTURED MICROORGANISM IN RECENT 12 YEARS

2007 ◽  
Vol 46 ◽  
pp. S99
Author(s):  
M.K. Park ◽  
J.H. Lee ◽  
Y.H. Byun ◽  
J.H. Song ◽  
B.C. Yoo ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Spontaneous Bacterial Peritonitis ◽  
Resistance Rate ◽  
Bacterial Peritonitis ◽  
Causative Agents

Antibiotic resistance in healthcare-related and nosocomial spontaneous bacterial peritonitis

2016 ◽  
Vol 47 (1) ◽  
pp. 44-52 ◽  
Author(s):  
Philipp Lutz ◽  
Hans Dieter Nischalke ◽  
Benjamin Krämer ◽  
Felix Goeser ◽  
Dominik J. Kaczmarek ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Spontaneous Bacterial Peritonitis ◽  
Bacterial Peritonitis

scholarly journals Nosocomial and Community-Acquired Spontaneous Bacterial Peritonitis in patients with liver cirrhosis in China: Comparative Microbiology and Therapeutic Implications

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Lei Shi ◽  
Dan Wu ◽  
Lei Wei ◽  
Suxia Liu ◽  
Peng Zhao ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Spontaneous Bacterial Peritonitis ◽  
Pathogenic Bacteria ◽  
Clinical Symptoms ◽  
Resistance Rate ◽  
Coagulase Negative Staphylococcus ◽  
Therapeutic Implications ◽  
Bacterial Peritonitis ◽  
Microbiological Characteristics ◽  
Susceptibility Tests

Abstract Spontaneous bacterial peritonitis (SBP) is a common complication of liver cirrhosis. This study was performed to compare the microbiological characteristics of nosocomial and community-acquired episodes of bacterial peritonitis in China. Five hundred and seventy-five strains were isolated from the ascitic fluid of cirrhotic patients from the Beijing 302 Hospital from January 2014 to December 2014. The patients in the community-acquired SBP (n = 264) and the nosocomial SBP (n = 311) groups exhibited significant differences in clinical symptoms (P < 0.01). In both groups, most of the bacteria were Escherichia coli, Klebsiella pneumoniae, coagulase-negative staphylococcus and Enterococcus. There were more frequent gram-positive cocci (G+ C) in the nosocomial group (n = 170). Compared with the community-acquired group, the proportion of Enterococcus was significantly increased in the nosocomial group (9.0% vs. 16.6%, P < 0.05). The resistance rate of the main pathogenic bacteria to the recommended first-line drug in the guideline was very high. Community-acquired and nosocomial SBP groups exhibited differences in clinical symptoms and antibiotic susceptibility tests. Optimal treatments should be provided for these patients. We recommend that cefoperazone/sulbactam or piperacillin/tazobactam should be used for the empirical treatment of SBP.

Microbial spectrum and antibiotic sensitivity in cirrhotic patients with spontaneous bacterial peritonitis

2021 ◽  
Vol 15 (11) ◽  
pp. 3123-3125
Author(s):  
Irfan Ahmad ◽  
Muhammad Shahbaz Hussain ◽  
Muhammad Shoaib Akhtar
Keyword(s):  
Ascitic Fluid ◽  
Spontaneous Bacterial Peritonitis ◽  
Antibiotic Sensitivity ◽  
High Sensitivity ◽  
Resistance Rate ◽  
Medical Department ◽  
College Hospital ◽  
Culture Bottle ◽  
Bacterial Peritonitis ◽  
Cirrhotic Patients

Objective: There are reports of changing microbial profile of ascitic fluid in spontaneous bacterial peritonitis (SBP) and developing resistance of these bacteria to commonly used antibiotics. This study was done to determine the micro-organism causing SBP and their sensitivity to various antibiotics. Setting and Methods: This observational study was done in Medical department of Sheikh Zayed Medical College/Hospital, Rahim Yar Khan from March to November 2019. Thirty five cirrhotic patients with ascites admitted in ward for various reasons and having positive ascitic fluid culture were included in the study. Exclusion criteria was presence of secondary bacterial peritonitis. Ten ml of ascitic fluid was inoculated in blood culture bottle and sent immediately to hospital laboratory. Results: The mean age of these 35 patients was 48.94 ± 13.51 years with a range of 19 to 80 years. Twenty (57.1 %) patients were male and 15 (42.9 %) were female. Bacteria that had caused SBP were E.coli (62.9 %), staph aureus (11.4 %), klebsiella (8.6 %), streptococci (8.6 %), gram positive cocci (5.7 %) and pseudomonas aeruginosa (2.8 %). Imipenem had high sensitivity rate (100 %) along with amikacin (82.9 %) and cefoperazone-sulbactam (68.6 %). Sensitivity of these organisms to other commonly used antibiotics were: ciprofloxacin 57.1 %, ofloxacin 40 %, norfloxacin 37.1 %, ceftazidime 34.3 %, ceftriaxone 31.4 % and piperacillin-tazobactam 25.7 %. Conclusion: We found that E.coli was the commonest bacteria causing SBP, and ceftriaxone and ciprofloxacin have significantly high resistance rate in these patients. Key words: cirrhosis, ascitic fluid, spontaneous bacterial peritonitis, antibiotic sensitivity

scholarly journals Enterococcus casseliflavus and Enterococcus gallinarum as causative agents of spontaneous bacterial peritonitis

2015 ◽  
Vol 14 (2) ◽  
pp. 270-272 ◽  
Author(s):  
Janaína Luz Narciso-Schiavon ◽  
Ariane Borgonovo ◽  
Paula Couto Marques ◽  
Débora Tonon ◽  
Emilia Tiemi Oshiro Bansho ◽  
...  
Keyword(s):  
Spontaneous Bacterial Peritonitis ◽  
Bacterial Peritonitis ◽  
Enterococcus Casseliflavus ◽  
Causative Agents ◽  
Enterococcus Gallinarum

scholarly journals Patterns of Antimicrobial Resistance in the Causative Organisms of Spontaneous Bacterial Peritonitis: A Single Centre, Six-Year Experience of 1981 Samples

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Sara Sheikhbahaei ◽  
Alireza Abdollahi ◽  
Nima Hafezi-Nejad ◽  
Elham Zare
Keyword(s):  
Spontaneous Bacterial Peritonitis ◽  
Resistance Rate ◽  
First Line ◽  
Cross Sectional ◽  
E Coli ◽  
Bacterial Peritonitis ◽  
Center Hospital ◽  
Resistant Strains ◽  
Empirical Antibiotics ◽  
Microbial Agents

Background/Aims. Spontaneous bacterial peritonitis (SBP) is one of the leading causes of morbidity and mortality in patients with cirrhosis. This study aims to determine the microbial agents of SBP and the pattern of antibiotic resistance, in a large number of ascitic samples.Methodology. In a cross-sectional, single center, hospital based study, 1981 consecutive ascitic fluid samples were recruited from 2005 to 2011. Samples were dichotomized into three-year periods, in order to assess the trend of resistance to the first-line empirical antibiotics.Results. SBP was found in 482 (24.33%) of samples, of which 314 (65.15%) were culture positive. The most prevalent isolated pathogen wasE. coli(33.8%), followed bystaphylococcus aureus(8.9%) andEnterococcus(8.6%). No significant changes in the proportion of gram-negative/gram-positive infections occurred during this period. A percentage of resistant strains to cefotaxime (62.5%, 85.7%), ceftazidim (73%, 82.1%), ciprofloxacin (30, 59.8%), ofloxacin (36.8%, 50%), and oxacilin (35%, 51.6%) were significantly increased.E. coliwas most sensitive to imipenem, piperacillin-tazobactam, amikacin, ceftizoxime, and gentamicin.Conclusions. The microbial aetiology of SBP remains relatively constant. However, the resistance rate especially to the first-line recommended antibiotics was significantly increased. This pattern must be watched closely and taken into account in empirical antibiotic treatment.

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