The Prevalence of Hepatitis D Virus in Reactive HBsAg Blood Donors at Department of Pathology, LUMHS Jamshoro

Background: The hepatitis delta virus (HDV) is a defective hepatotropic virus that only affects patients infected with the hepatitis B virus (HBV). Infection with the hepatitis delta virus can cause acute hepatitis, including the fulminant presentation or spontaneously resolving infection and chronic infection Aim: The present study's aim was to determine the prevalence of the Hepatitis D virus in reactive HBsAg blood donors at Diagnostic and Research Lab Hyderabad. Materials and Methods: This cross-sectional study was conducted on 434 blood donors at the Pathology department (Diagnostic and Research Laboratory) Civil Hospital, Hyderabad from January 2017 to December 2017. All the healthy individuals who visited at Diagnostic and Research Laboratory of Civil Hospital, LUMHS Hyderabad as blood donors with specific age groups of either gender were included in this study. All the individuals underwent Hepatitis screening. All of those cases that were noted with positive HBV further underwent HDV screening test. All the data was recorded in the proforma for the purposed of analysis. SPSS version 20 was used for data analysis. Results: Of the total 434 blood donors, 420 (96.8%) were male and 14 (3.2%) were female. The overall mean age was 31.65±4.67 years with an age range of 18 to 60 years. Out of 434, the incidence of positive delta virus was 62 (14.3%) while the remaining 372 (85.7%) were negative delta hepatitis blood donors. The prevalence of delta hepatitis blood donors with respect to age distribution were as follows; 18-30 years had 208 (48%), 31-40 years had 188 (27%), 41-50 years 69 (16%), and 51-60 years 39 (9%). Of the total 62 positive delta hepatitis, the prevalence of males and females was 98.4% and 1.6% respectively. All the donor’s blood group was divided into +O, +B, +A, +AB, -O, -A, and –B with their respective prevalence was 48.6%, 22.6%. 11.5%, 8.8%, 2.5%, 3.5%, and 2.5% whereas their frequency in positive tested delta hepatitis was 36 (58.1%), 7 (11.3%), 10 (16.1%), 6 (9.7%), 1 (1.6%), 2 (3.2%), and 0 (0%) respectively. Conclusion: It is concluded that the prevalence of HDV is 14.3% in Hepatitis B reactive healthy donors. This is a higher prevalence as compared to previously published studies. No such adequate recent data is available at the local level. More research is needed on this event, to provide adequate knowledge, which will be helpful to clinical and laboratory investigators, and physicians to reduce the burden of liver disease caused by HBV and HDV co-infection. Keywords: Hepatitis delta virus; HBsAg reactivity; Blood donors;

Frequency of Helicobacter Pylori in Patients with Dyspepsia in Civil Hospital, Khairpur

Background: The Helicobacter pylori is a gram negative bacterium which is found in majority of population in all over the world. It is possible due to contaminated food consumption, working in unsanitary condition and the use of public toilets with poor sanitation. In the field of gastroenterology infection caused by H. pylori and functional dyspepsia are most common clinical issue but their association is also unclear. Aim: To determine the frequency of Helicobacter Pylori in patients with presenting with Dyspepsia in Civil Hospital, Khairpur Study Design: Descriptive Cross sectional study. Duration of study: One year from 01-Jan- 2019 to 31-12-2019. Setting: Institute of Microbiology, Shah Abdul Latif University, Khairpur. Methodology: All the patients between 15 to 60 years of age, admitted patients of dyspepsia were diagnosed and evaluated for Helicobacter pylori infection through histopathological examination. Results: Total 100 subjects with dyspepsia were screened for Helicobacter pylori infection. Mean age of patients was 40.0 ±15.40. Majority of patients with H. pylori positive were from age group between 40-60 years, from which 56.7% of them were H. pylori positive; while 30% of patients were from age between 20-40 years of age and only 13.3% were from age below 20 years of age Conclusion: The dyspeptic patients are prone to acquire Helicobacter pylori infection therefore present study reported 30% prevalence for H. pylori infection with male gender predominance. Key words: Dyspepsia, Helicobacter Pylori Infection, Peptic ulcer, histopathology, endoscopy

Reported Cases of Sexual Assault in Civil Hospital Sanghar

Aim: To evaluate the sexual assault against male and female. Study design: Retrospective study Place and duration of study: Civil Hospital Sanghar from 1st January 2020 to 31st December, 2020 Methodology: Forty two cases of sexual assault and recognize the associated factors were enrolled. The age between 6-35 years and either gender were included. Result: There were 28.6% females and 71.4% males, highest victims were among age between 6-18 years was 17(40.5%), illiterate was 23(54.7%), assaulted by a neighbour was 30 (71.4%) and time lapse <1-2 days was 19(45.4%) sexual assaults. Conclusion: Majority of victims were males, assailant relationships of neighbour and illiterate. Keywords: Sexual assault, Victims, Assailants

Study of Clinical Forensic Examination Reports and Alleged Offences in Sexual Assault Cases: Civil Hospital Sanghar

Background: Several factors influence the occurrence of genito-anal injuries in sexual assault victims. The occurrence of injuries aids in the future laying of accusations against the accused, making forensic examination, documenting of injuries, and report preparation difficult for healthcare personnel. Aim: To find out the pattern of genito-anal injuries and the circumstances that lead to charges being filed against the accused. Place and Duration of Study: Civil Hospital Sanghar from 1st January 2019 to 31st December, 2019. Methodology: This cross-sectional study Sixty sexual assault cases were incorporated all survivors of rape, paying little heed to age, who announced a background marked by rape to the police or straightforwardly to our tertiary consideration community. Result: Penile-anal penetration is the most common 82.4% and second most common was penile-oral penetration was 75%. Fifty percent of ano-genital bleeding was found in the sexual assault victims and 45.6% were physical assault during sexual assault. Mostly cases were based on incomplete investigation with the highest 47.1%. Conclusion: Although no single event will bring the victim's recovery to a close, the arrest and successful conviction of the offender can be a significant step forward. Contrary to popular assumption, genital damage is not the usual in the aftermath of sexual assault. Keywords: Sexual assault, alleged, offences

Interventional Study on Adherence to Pharmacotherapy and Drug Pattern in Elderly Patients at Civil Hospital of Badin, Pakistan

Background: To assess the contributing factors to adherence of pharmacotherapy and perception of elderly patients. Methods: This prospective cross-sectional study was conducted in the outpatient clinic of Civil Hospital Badin, Pakistan from January to June 2019. A total of 300 samples were selected to analyze the results. A self-designed proforma (prescribing indicator form) was used for collecting data including patient demographics, diagnosis, and the current medications prescribed for each patient. Results: Of the 300 selected participants, 221(73.7%) were male, while 79 (26.3%) were female. Majority of the subjects in the age group of 60–69 (52%) and 70–79 years (27%) followed by those aged >79 (21%). Antibiotics were prescribed to 17.2% and vitamins to 14.7%. Patients’ responses related to nonadherence factor were 92.7% for the cost, 32.7% for the long treatment duration, and 24% for the lack of knowledge. Out of the total patients, 28% were forgetful, 26.7% complained about complex therapy, 26.3% blamed financial problems, 19.7% patients had side effects, and 14.3% were negligent in taking the medication. Conclusion: Patient conformity can be enhanced by dropping polypharmacy and simplifying complex management, use of extended formulations, rate of medications, and by creating awareness among elderly patients. Keywords: elderly, polypharmacy, pharmacotherapy, adherence

Clinico-pathological study of oesophageal cancer: a 3 years retrospective and 1½ year’s prospective analysis

Background: In India, oesophageal cancer is second most common cancer among males and fourth most common among females and is associated with certain diets and lifestyle. In India, the age-adjusted incidence rates for oesophageal cancer are the highest in men (25.5) and women (5.5) in Mizoram. Aim of the study was to find the clinical and histopathological findings of oesophageal cancer patients at Civil Hospital, Aizawl.Methods: A descriptive study (3 years retrospective and 1½ years prospective) was conducted at Civil Hospital, Aizawl, Mizoram from July 2013 to December 2014 (1½ years) amongst 104 patients reporting to Civil Hospital, Aizawl for oesophageal cancer.Results: History of progressive dysphagia to solids was most common symptom and observed in 91.3% patients. Histopathological examination of resected esophageal specimen showed 95.7% patients were detected with squamous cell carcinoma, 4.3% patients were detected with no proper malignancy/residual tumor.Conclusion: Squamous-cell carcinoma was the most common type of esophageal cancer occurring in the middle third of the oesophagus with as observed on upper gastrointestinal (GI) endoscopy. More men were affected than female.

Occurence of Genotypes of Hepatitis C Virus in Hepatitis C Patients at Civil Hospital Khairpur, Sindh, Pakistan

Objective: To evaluate frequency of Hepatitis C virus Genotypes in Hepatitis C patients reported at Civil Hospital Khairpur, Sindh, Pakistan. Methodology: A descriptive cross sectional study was conducted on 223 hepatitis C patients who fulfilled the criteria at hepatitis OPD of Civil Hospital Khairpur, Sindh, Pakistan. After taken Patient consent, blood sample were collected for HCV genotyping, which were performed by a qualified pathologist. The collected data statistically analyzed by using SPSS version 22 software. Result: Out of 223 patients, male patients were 167 and females patients were 56, rural patients were 130 where as 93 patients were from urban area, 30 patients were of age from 20-25 years, 41 were of age from 26-30 years, 60 were of 31-35 years, 54 were of 36-40 years, 16 were of 41-45 years, 13 were of 46-50 years, 7 were of 51-55 years, 2 were of 56-60 years, out of total n=11 patients have genotype1, n=4 have genotype2, n=204 have genotype3, n=3 have genotype4, n=1 have genotype5, whereas no any patient have genotype 6. Conclusion: This study concluded that genotype 3 is most dominant among other genotypes in reported patients of hepatitis c virus infection at civil hospital Khairpur.

A Study to Assess the emotional Response and coping Strategies of care giver Worked in covid-19 department at Civil Hospital, Ahmedabad

Background: Care givers, who are the front-line health workers during Covid-19 outbreak. Their emotional responses and adaptation of coping strategies are very important for health of themselves as well health services. Logically care givers emotional response and coping strategies measures their emotional well-being which also affects their work productivity. Hence, this study is undertaken to assess the emotional response and coping strategies of care givers in Covid-19 department at Civil hospital, Ahmedabad. Aims and objectives: To assess the emotional response and coping strategies of care givers worked in Covid-19 department at Civil hospital, Ahmedabad. To assess the association between emotional response and demographic variables, coping strategies and demographic variables. Materials and Methods: The study was conducted among 100 care givers worked in Covid-19 department at Civil hospital, Ahmedabad using Random sampling technique. Data were obtained using structured rating scale and checklist to assess emotional response and coping strategies of care givers. Descriptive and inferential statistics were used to analyze demographic data, rating scale and checklist. Results and Conclusions: The study reveled that majority of 73% of caregivers had emotionally strong response and 86% of caregivers adopted healthy coping strategies. Study also revealed that there is significant association between selected emotional responses and selected demographic variables. Also significant association between coping strategies and selected demographic variables.