573 ATTENUATION OF OXIDATIVE STRESS PROTECTS THE BRAIN IN RATS WITH “ACUTE-ON-CHRONIC” LIVER FAILURE

2013 ◽  
Vol 58 ◽  
pp. S235
Author(s):  
C.R. Bosoi ◽  
C. Bemeur ◽  
B. Nguyen ◽  
M. Tremblay ◽  
C.F. Rose
Keyword(s):  
Oxidative Stress ◽  
Liver Failure ◽  
Chronic Liver ◽  
Chronic Liver Failure ◽  
The Brain

scholarly journals Protective Effects of Taraxacum officinale L. (Dandelion) Root Extract in Experimental Acute on Chronic Liver Failure

Antioxidants ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 504
Author(s):  
Iulia Olimpia Pfingstgraf ◽  
Marian Taulescu ◽  
Raluca Maria Pop ◽  
Remus Orăsan ◽  
Laurian Vlase ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Failure ◽  
Tissue Injury ◽  
Taraxacum Officinale ◽  
Chronic Liver ◽  
Root Extract ◽  
Protective Effects ◽  
Stress Tests ◽  
Chronic Liver Failure

Background: Taraxacum officinale (TO) or dandelion has been frequently used to prevent or treat different liver diseases because of its rich composition in phytochemicals with demonstrated effect against hepatic injuries. This study aimed to investigate the possible preventing effect of ethanolic TO root extract (TOERE) on a rat experimental acute on chronic liver failure (ACLF) model. Methods: Chronic liver failure (CLF) was induced by human serum albumin, and ACLF was induced in CLF by D-galactosamine and lipopolysaccharide (D-Gal-LPS). Five groups (n = 5) of male Wistar rats (200–250 g) were used: ACLF, ACLF-silymarin (200 mg/kg b.w./day), three ACLF-TO administered in three doses (200 mg, 100 mg, 50 mg/kg b.w./day). Results: The in vivo results showed that treatment with TOERE administered in three chosen doses before ACLF induction reduced serum liver injury markers (AST, ALT, ALP, GGT, total bilirubin), renal tests (creatinine, urea), and oxidative stress tests (TOS, OSI, MDA, NO, 3NT). Histopathologically, TOERE diminished the level of liver tissue injury and 3NT immunoexpression. Conclusions: This paper indicated oxidative stress reduction as possible mechanisms for the hepatoprotective effect of TOERE in ACLF and provided evidence for the preventive treatment.

scholarly journals The brain in acute on chronic liver failure

2014 ◽  
Vol 29 (4) ◽  
pp. 965-973 ◽  
Author(s):  
Gavin Wright ◽  
Yalda Sharifi ◽  
Maria Jover-Cobos ◽  
Rajiv Jalan
Keyword(s):  
Liver Failure ◽  
Chronic Liver ◽  
Chronic Liver Failure ◽  
The Brain

Acute-on-chronic liver failure: the brain

2011 ◽  
Vol 17 (2) ◽  
pp. 177-183 ◽  
Author(s):  
Rita García-Martínez ◽  
Juan Córdoba
Keyword(s):  
Liver Failure ◽  
Chronic Liver ◽  
Chronic Liver Failure ◽  
The Brain

Monitoring oxidative stress in acute-on-chronic liver failure by advanced oxidation protein products

2011 ◽  
Vol 42 (2) ◽  
pp. 171-180 ◽  
Author(s):  
Hua Liu ◽  
Tao Han ◽  
Jie Tian ◽  
Zheng-Yan Zhu ◽  
Ying Liu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Failure ◽  
Advanced Oxidation ◽  
Chronic Liver ◽  
Chronic Liver Failure ◽  
Advanced Oxidation Protein Products

scholarly journals Systemic oxidative stress is implicated in the pathogenesis of brain edema in rats with chronic liver failure

2012 ◽  
Vol 52 (7) ◽  
pp. 1228-1235 ◽  
Author(s):  
Cristina R. Bosoi ◽  
Xiaoling Yang ◽  
Jimmy Huynh ◽  
Christian Parent-Robitaille ◽  
Wenlei Jiang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Failure ◽  
Brain Edema ◽  
Chronic Liver ◽  
Chronic Liver Failure ◽  
Systemic Oxidative Stress

scholarly journals Bacopa monnieriExtract (CDRI-08) Modulates the NMDA Receptor Subunits and nNOS-Apoptosis Axis in Cerebellum of Hepatic Encephalopathy Rats

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Papia Mondal ◽  
Surendra Kumar Trigun
Keyword(s):  
Nitric Oxide ◽  
Hepatic Encephalopathy ◽  
Liver Failure ◽  
Chronic Liver ◽  
Chronic Liver Failure ◽  
Apoptosis Pathway ◽  
Nitric Oxide Level ◽  
Nmdar Activation ◽  
Oxide Synthase ◽  
The Brain

Hepatic encephalopathy (HE), characterized by impaired cerebellar functions during chronic liver failure (CLF), involves N-methyl-D-aspartate receptor (NMDAR) overactivation in the brain cells.Bacopa monnieri(BM) extract is a known neuroprotectant. The present paper evaluates whether BM extract is able to modulate the two NMDAR subunits (NR2A and NR2B) and its downstream mediators in cerebellum of rats with chronic liver failure (CLF), induced by administration of 50 mg/kg bw thioacetamide (TAA) i.p. for 14 days, and in the TAA group rats orally treated with 200 mg/kg bw BM extract from days 8 to 14. NR2A is known to impart neuroprotection and that of NR2B induces neuronal death during NMDAR activation. Neuronal nitric oxide synthase- (nNOS-) apoptosis pathway is known to mediate NMDAR led excitotoxicity. The level of NR2A was found to be significantly reduced with a concomitant increase of NR2B in cerebellum of the CLF rats. This was consistent with significantly enhanced nNOS expression, nitric oxide level, and reduced Bcl2/Bax ratio. Moreover, treatment with BM extract reversed the NR2A/NR2B ratio and also normalized the levels of nNOS-apoptotic factors in cerebellum of those rats. The findings suggest modulation of NR2A and NR2B expression by BM extract to prevent neurochemical alterations associated with HE.

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