P1207 TRIPLE THERAPY FOR HCV CIRRHOSIS IN LIVER TRANSPLANT CANDIDATES. HIGH RATE OF PREVENTION OF HCV RECURRENCE AFTER LIVER TRANSPLANTATION (LT) IN WELL SELECTED PATIENTS

2014 ◽  
Vol 60 (1) ◽  
pp. S490 ◽  
Author(s):  
A. Braithwaite ◽  
V. Aguilera ◽  
C. Vinaixa ◽  
M. Garcia ◽  
S. Benlloch ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Transplant ◽  
Triple Therapy ◽  
High Rate ◽  
Transplant Candidates

Cholecystitis in Patients Undergoing Liver Transplantation: A Five-Year Analysis of Incidence, Causes, and Impact

2020 ◽  
Vol 86 (10) ◽  
pp. 1254-1259
Author(s):  
Danielle S. Graham ◽  
Takahiro Ito ◽  
Michelle Lu ◽  
Joseph Dinorcia ◽  
Vatche G. Agopian ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Transplant ◽  
Patient Population ◽  
Patient Survival ◽  
Kaplan Meier ◽  
High Acuity ◽  
Transplant Candidates ◽  
Pathology Reports ◽  
End Stage ◽  
High Index Of Suspicion

There is a paucity of data on cholecystitis in liver transplant candidates (LTC), including the incidence of the cholecystitis and the associated outcomes in this patient population. As such, this study examines the incidence of and factors associated with cholecystitis in the high-acuity LTC population, as well as the association between cholecystitis and graft and patient survival. Liver transplant candidates undergoing orthotopic liver transplantation (OLT) at a large transplant center from January 1, 2012 to December 31, 2016 were included in the initial analysis. Surgical pathology reports were examined for the presence of cholecystitis. Univariate analyses were performed to determine the association between patient factors and cholecystitis. Kaplan-Meier analyses and multivariate Cox proportional hazard models were performed to examine the association between cholecystitis and graft and patient survival. Of the 405 patients in the final study population, 267 (65.9%) had no cholecystitis, 21 (5.2%) had acute cholecystitis, and 117 (28.9%) had chronic cholecystitis. The presence of cholecystitis was associated with preoperative WBC, sepsis within 10 days prior to transplant, location prior to transplant, and total length of stay. While this study revealed no association between cholecystitis and graft or patient survival, it also suggests that cholecystitis is under-recognized in high-model end-stage liver disease (MELD) OLT candidates. Therefore, a high index of suspicion for cholecystitis may be helpful in caring for this vulnerable patient population; however, further studies must be performed to determine the optimal management of cholecystitis in these patients.

scholarly journals Visceral Artery Aneurysms in Liver Transplant Candidates and in Patients after Liver Transplantation

PLoS ONE ◽  
2011 ◽  
Vol 6 (12) ◽  
pp. e29544 ◽  
Author(s):  
Umberto Maggi ◽  
Daniele Dondossola ◽  
Dario Consonni ◽  
Stefano Gatti ◽  
Rossella Arnoldi ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Transplant ◽  
Visceral Artery ◽  
Visceral Artery Aneurysms ◽  
Transplant Candidates

scholarly journals The Impact of Cirrhosis and Prescription Medications on QTc Interval Before and After Liver Transplantation

2017 ◽  
Vol 32 (1) ◽  
pp. 48-53 ◽  
Author(s):  
Andrew D. Santeusanio ◽  
Kevin G. Dunsky ◽  
Stephanie Pan ◽  
Thomas D. Schiano
Keyword(s):  
Liver Transplantation ◽  
Liver Transplant ◽  
Qtc Interval ◽  
Prescription Medications ◽  
Qtc Prolongation ◽  
Before And After ◽  
Group 2 ◽  
Transplant Candidates ◽  
The Impact ◽  
Group 1

Background: Higher rates of corrected QT (QTc) prolongation have been reported in patients with cirrhosis. The impact of liver transplantation and prescription medications on the natural history of QTc prolongation has yet to be well characterized. Methods: This was a single-center review of patients receiving (group 1) or listed for (group 2) a liver transplant during 2014. Patients in group 1 were followed prospectively from the date of transplantation to assess rates of QTc normalization posttransplant. In group 2, patients were evaluated from the date of listing up until December 2015 to assess the prevalence of QTc prolongation among liver transplant candidates. Results: In group 1, 22 (75.9%) patients with QTc intervals >460 milliseconds at the time of transplant established normal baseline QTc intervals following transplantation. The median time to this QTc normalization was 17 days. In group 2, 30 (16.9%) patients had at least 1 documented QTc interval >500 milliseconds with prevalence rates of 42.9%, 19.0%, and 10.2% in patients with natural model of end-stage liver disease scores of >30, 16 to 30, and <16, respectively ( P < .01). Overall, 49.4% of patients in group 1 and 47.5% of patients in group 2 were prescribed QTc prolonging medications. Conclusion: QTc prolongation will resolve following transplantation in the majority of patients and generally occurs within the first several weeks. Among the listed liver transplant candidates, higher rates of clinically significant QTc prolongation may be observed in patients with more severe underlying cirrhosis. QTc prolonging medications are commonly prescribed in this population and warrant monitoring following initiation.

scholarly journals Common cardiac comorbidities and perioperative assessment modalities for liver transplant candidates – an update

2020 ◽  
Vol 12 (1) ◽  
pp. 49-60
Author(s):  
F. Hackl ◽  
A. V. Kopylov ◽  
M. D. Kaufman
Keyword(s):  
Liver Transplantation ◽  
Liver Transplant ◽  
Conflict Of Interest ◽  
Early Mortality ◽  
Cardiac Complications ◽  
Transplant Candidates ◽  
Cardiovascular Evaluation ◽  
Perioperative Assessment

Cardiac complications are currently the leading cause of early mortality following liver transplantation. Guidelines for the cardiac workup prior liver transplantation are limited. In this review we are discussing commonly modalities used for cardiovascular evaluation of liver transplant candidates.Authors declare no conflict of interest.

International Liver Transplantation Society Consensus Statement on Hepatitis C Management in Liver Transplant Candidates

2017 ◽  
Vol 101 (5) ◽  
pp. 945-955 ◽  
Author(s):  
Norah A. Terrault ◽  
Geoff W. McCaughan ◽  
Michael P. Curry ◽  
Edward Gane ◽  
Stefano Fagiuoli ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Hepatitis C ◽  
Liver Transplant ◽  
Consensus Statement ◽  
Transplant Candidates ◽  
Transplantation Society

A peer-based intervention to educate liver transplant candidates about living donor liver transplantation

2009 ◽  
Vol 16 (1) ◽  
pp. 42-48 ◽  
Author(s):  
Samantha DeLair ◽  
Thomas Hugh Feeley ◽  
Hyunjung Kim ◽  
Juan del Rio Martin ◽  
Leona Kim-Schluger ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Transplant ◽  
Living Donor ◽  
Living Donor Liver Transplantation ◽  
Donor Liver ◽  
Donor Liver Transplantation ◽  
Transplant Candidates

Abstract 18872: The Prognostic Utility of Risk Factors Defined by the AHA/ACCF Expert Consensus Statement on the Evaluation of Cardiac Disease in Liver Transplantation Candidates

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Hena Patel ◽  
Sarah Alexander ◽  
Meron Teshome ◽  
Ahmad Alkhalil ◽  
Edie Chan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Liver Transplantation ◽  
Liver Transplant ◽  
Consensus Statement ◽  
Expert Consensus ◽  
Optimal Threshold ◽  
Transplant Recipients ◽  
Cardiac Evaluation ◽  
Transplant Candidates ◽  
Liver Transplant Recipients

Introduction: The 2012 AHA/ACCF expert consensus statement regarding cardiac evaluation of liver transplant candidates specifies 7 risk factors for identifying candidates for cardiac evaluation prior to liver transplantation. These include age > 60 yrs, hypertension, diabetes, smoking, dyslipidemia, prior cardiovascular disease, and left ventricular hypertrophy. The prognostic value of these risk factors in predicting major adverse cardiac events (MACE) has not been established. Furthermore, the optimal threshold of the sum of risk factors to predict MACE has not been determined. Hypothesis: Risk factors set forth by the AHA/ACCF can predict MACE in liver transplant candidates. We sought to identify an optimal threshold sum of risk factors to predict MACE. Methods: We conducted a retrospective cohort study of consecutive liver transplant recipients who were followed for MACE, defined as a composite of cardiac death, myocardial infarction, or coronary revascularization. Kaplan-Meier plots, log-rank test, and Cox regression models were used in outcome analyses. Results: We retrospectively followed 193 consecutive liver transplant recipients (40% female, mean age 55±10 yrs) for a mean of 51±29 months, during which 24 MACE were observed. Having ≥2 AHA/ACCF risk factors was associated with increased MACE risk (HR, 2.75, P=0.02), whereas having ≥3 risk factors was associated with greater MACE risk (HR, 4.14, P<0.001), Figure 1. Using ≥1 risk factor threshold provided insignificant predictive value of event-free survival (P=0.29). Conclusion: This study provides prognostic validation of risk factors set forth by the AHA/ACCF consensus statement for cardiac evaluation in liver transplant candidates. Having ≥2 risk factors is most sensitive for predicting MACE and seems optimal for triggering CAD surveillance in asymptomatic liver transplant candidates.

scholarly journals ACUTE APENDICITIS IN LIVER TRANSPLANT RECIPIENTS

2016 ◽  
Vol 29 (1) ◽  
pp. 30-32 ◽  
Author(s):  
Olival Cirilo Lucena da FONSECA-NETO ◽  
Heloise Caroline de Souza LIMA ◽  
Paulo Sérgio Vieira de MELO ◽  
Roberto LEMOS ◽  
Laércio LEITÃO ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Acute Appendicitis ◽  
Liver Transplant ◽  
Hospital Stay ◽  
Iliac Fossa ◽  
Rare Event ◽  
High Rate ◽  
Transplant Recipients ◽  
Superficial Infection ◽  
Liver Transplant Recipients

Background: Appendicitis is a common cause of emergency surgery that in the population undergoing organ transplantation presents a rare incidence due to late diagnosis and treatment. Aim: To report the occurrence of acute appendicitis in a cohort of liver transplant recipients. Methods: Retrospective analysis in a period of 12 years among 925 liver transplants, in witch five cases of acute appendicitis were encountered. Results: Appendicitis occurred between three and 46 months after liver transplantation. The age ranged between 15 and 58 years. There were three men and two women. The clinical presentations varied, but not discordant from those found in non-transplanted patients. Pain was a symptom found in all patients, in two cases well located in the right iliac fossa (40%). Two patients had symptoms characteristic of peritoneal irritation (40%) and one patient had abdominal distention (20%). All patients were submitted to laparotomies. In 20% there were no complications. In 80% was performed appendectomy complicated by suppuration (40%) or perforation (40%). Superficial infection of the surgical site occurred in two patients, requiring clinical management. The hospital stay ranged from 48 h to 45 days. Conclusion: Acute appendicitis after liver transplantation is a rare event being associated with a high rate of drilling, due to delays in diagnosis and therapy, and an increase in hospital stay.

Sign in / Sign up

Export Citation Format

Share Document