Field evaluation of Xpert ® HCV Viral Load point-of-care test for detection of hepatitis C virus infection by venipuncture-collected and finger-stick capillary whole-blood samples

2017 ◽  
Vol 66 (1) ◽  
pp. S709
Author(s):  
J. Grebely ◽  
F. Lamoury ◽  
B. Hajarizadeh ◽  
Y. Mowat ◽  
A. Marshall ◽  
...  
2017 ◽  
Vol 2 (7) ◽  
pp. 514-520 ◽  
Author(s):  
Jason Grebely ◽  
Francois M J Lamoury ◽  
Behzad Hajarizadeh ◽  
Yasmin Mowat ◽  
Alison D Marshall ◽  
...  

Diagnostics ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 473
Author(s):  
Fernando Velásquez-Orozco ◽  
Ariadna Rando-Segura ◽  
Joan Martínez-Camprecios ◽  
Paula Salmeron ◽  
Adrián Najarro-Centeno ◽  
...  

Diagnosis and clinical management of people infected with hepatitis C virus (HCV) relies on results from a combination of serological and virological tests. The aim of this study was to compare the performance of dried plasma spots (DPS), prepared using the cobas® Plasma Separation Card (PSC), to plasma and serum from venipuncture, for HCV diagnosis. We carried out a prospective study using DPS and paired plasma or serum samples. Serum and DPS samples were analyzed by immunoassay using Elecsys® Anti-HCV II (Roche). Plasma and DPS samples were analyzed using the cobas® HCV viral load and cobas® HCV genotyping tests (Roche). All DPS samples that had high anti-HCV antibody titers in serum were also antibody-positive, as were five of eight samples with moderate titers. Eight samples with low titers in serum were negative with DPS. Among 80 samples with plasma HCV viral loads between 61.5 and 2.2 × 108 IU/mL, 74 were RNA-positive in DPS. The mean viral load difference between plasma and DPS was 2.65 log10 IU/mL. The performance of DPS for detection of serological and virological markers of hepatitis C virus infection was comparable to that of the conventional specimen types. However, the limits of detection were higher for DPS.


2000 ◽  
Vol 69 (Supplement) ◽  
pp. S218
Author(s):  
Valeria R. Mas ◽  
Teresita R. Alvarellos ◽  
Susana M. Albano ◽  
Constancio A. Giraudo ◽  
Carlos R. Chiurchiu ◽  
...  

AIDS ◽  
2018 ◽  
Vol 32 (5) ◽  
pp. 653-661 ◽  
Author(s):  
Sarah J. Willis ◽  
Stephen R. Cole ◽  
Daniel Westreich ◽  
Andrew Edmonds ◽  
Christopher B. Hurt ◽  
...  

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