scholarly journals Restoration of Serotonin Biosynthesis in Cell Suspension Cultures of Peganum harmala by Selection for 4-methyltryptophan-tolerant Cell Lines

1987 ◽  
Vol 131 (3-4) ◽  
pp. 225-236 ◽  
Author(s):  
Jochen Berlin ◽  
Christiane Mollenschott ◽  
Florenz Sasse ◽  
Ludger Witte ◽  
Gerd-Walter Piehl ◽  
...  
Keyword(s):  
Cell Suspension ◽  
Cell Lines ◽  
Cell Suspension Cultures ◽  
Suspension Cultures ◽  
Peganum Harmala ◽  
Selection For ◽  
Serotonin Biosynthesis ◽  
Tolerant Cell

scholarly journals Extracts from Cell Suspension Cultures of Strawberry (Fragaria x ananassa Duch): Cytotoxic Effects on Human Cancer Cells

Molecules ◽  
2019 ◽  
Vol 24 (9) ◽  
pp. 1738 ◽  
Author(s):  
Simona Lucioli ◽  
Fabio Pastorino ◽  
Paolo Nota ◽  
Giulia Ballan ◽  
Andrea Frattarelli ◽  
...  
Keyword(s):  
Cell Suspension ◽  
Cell Lines ◽  
Human Cancer ◽  
Mass Measurement ◽  
Human Fibroblasts ◽  
Cell Suspension Cultures ◽  
Suspension Cultures ◽  
Chromatographic Retention ◽  
Cervix Carcinoma

Natural compounds are emerging as agents for the treatment of malignant diseases. We previously showed that extracts from in vitro cell suspension cultures of strawberry reduced murine melanoma cell proliferation, as shown for fruit extracts. In this work, chromatographic, mass spectrometric, and spectrophotometric analyses were carried out to identify the bioactive compound exerting the detected cytotoxic activity. Moreover, aiming to confirm the anti-proliferative activity of the extracts against both paediatric and adult human tumors, cytotoxic experiments were performed on neuroblastoma, colon, and cervix carcinoma cell lines. Extracts from in vitro cell suspension cultures of strawberry induced a statistically significant reduction of cell growth in all the tumor cell lines tested. Interestingly, human fibroblasts from healthy donors were not subjected to this cytotoxic effect, highlighting the importance of further preclinical investigations. The accurate mass measurement, fragmentation patterns, and characteristic mass spectra and mass losses, together with the differences in chromatographic retention times and absorbance spectra, led us to hypothesize that the compound acting as an anti-proliferative agent could be a novel acetal dihydrofurofuran derivative (C8H10O3, molecular mass 154.0630 amu)

Conversion of tryptamine to serotonin by cell suspension cultures of Peganum harmala

1988 ◽  
Vol 27 (10) ◽  
pp. 3137-3142 ◽  
Author(s):  
Didier Courtois ◽  
Daniel Yvernel ◽  
Bruno Florin ◽  
Vincent Petiard
Keyword(s):  
Cell Suspension ◽  
Cell Suspension Cultures ◽  
Suspension Cultures ◽  
Peganum Harmala
Sign in / Sign up

Export Citation Format

Share Document