cervix carcinoma
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2022 ◽  
Vol 198 ◽  
pp. 110012
Author(s):  
Asiye Gök Yurttaş ◽  
Altuğ Mert Sevim ◽  
Kamil Çınar ◽  
Göknur Yaşa Atmaca ◽  
Ali Erdoğmuş ◽  
...  

2022 ◽  
Author(s):  
Amritpal Kaur ◽  
Yash Sharma ◽  
Kamran Waidha ◽  
Madhumita P Ghosh ◽  
Anoop Kumar ◽  
...  

Abstract Abrus precatorius is a widely distributed tropical medicinal plant with several therapeutic properties, however its seed extract has not been studied against cervical cancer (CaCx) till date. Herein, we have assessed the antioxidant and antiproliferative properties of A. precatorius seed extracts (ethyl acetate and 70% ethanol) prepared from different extraction methods (Soxhlet and maceration) against human cervix carcinoma cells (Hep2C). We observed a significantly higher total flavonoid content of APE (sox) i.e.,112.7±0.127 mg Quercetin Equivalent/g of extract than others; total phenolic content of APA (mac) seed extract was higher i.e.,108.53±0.089 mg Quercetin Equivalent/g of extract and total tannin content of APA (sox) was higher i.e., 98.98± 0.011 mg tannic acid equivalents/g of extract. In addition, tannic acid, rutin and piperine were identified in extracts by HPLC. Furthermore, APA (sox) exhibited the highest radical scavenging activity with an IC50 value of 14.49±0.93µg/ml. APE (mac) showed the most significant antiproliferative activity with IC50 value of 85.90±0.93µg/mL against Hep2c cells. SOD and GST activity was observed as highest in the APA(Mac) extract whereas the catalase activity and GSH content was maximum in the APE(Mac) extract. Further, the MDA content was observed to be the least in APE(Mac) extracts. Docking results suggested maximum binding energy between tannic acid and Her2 receptor compared to doxorubicin (standard). This study provides evidence that A. precatorius seed extracts possess promising bioactive compounds with probable anticancer and antioxidant properties against CaCx which might be utilized as a possible herbal remedy aimed at restricting tumor growth.


2022 ◽  
Author(s):  
Aleksandar Radivoievych ◽  
Benjamin Kolp ◽  
Sergii Grebinyk ◽  
Svitlana Prylutska ◽  
Uwe Ritter ◽  
...  

Abstract The acoustic pressure waves of ultrasound (US) penetrate biological tissues deeper than light. Another important feature of US its potential to generate light emission within the excited medium termed sonoluminescence. This promoted the idea of its use as an alternative energy source for photosensitizer excitation. Pristine C60 fullerene (C60), an excellent photosensitizer, was explored in the frame of cancer sonodynamic therapy (SDT). For that purpose, we analyzed C60 effects on human cervix carcinoma HeLa cells in combination with a low intensity US treatment. The time-dependent accumulation of C60 in HeLa cells reached its maximum at 24 h (800 ± 66 ng / 106 cells). Half of extranuclear C60 localized within mitochondria. The efficiency of C60 nanostructure’s sonoexcitation with 1 MHz US was tested with cell viability assay. A significant proapoptotic sonotoxic effect was found for HeLa cells. C60’s ability to induce apoptosis of carcinoma cells after sonoexcitation with US provides a promising novel approach for cancer treatment.


Processes ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 2100
Author(s):  
Monika Richert ◽  
Renata Mikstacka ◽  
Mariusz Walczyk ◽  
Marcin Janusz Cieślak ◽  
Julia Kaźmierczak-Barańska ◽  
...  

Gold(I) complexes with phosphine ligands—[Au(TrippyPhos)Cl] (1) (TrippyPhos = 1-[2-[bis(tert-butyl)phosphino]phenyl]-3,5-diphenyl-1H-pyrazole), [Au(BippyPhos)Cl]0.5CH2Cl2 (2) (BippyPhos = 5-(di-tert-butylphosphino)-1′, 3′, 5′-triphenyl-1′H-[1,4′]bipyrazole), and [Au(meCgPPh)Cl] (3) (meCgPPh = 1,3,5,7-tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane—were investigated as types of bioactive gold metallodrugs. Complexes (1)–(3) were characterized using IR, 1H, 13C, 31P NMR spectroscopy, elemental analysis and mass spectrometry (FAB-MS). Complexes of (1) and (2) exhibited substantial in vitro cytotoxicity (IC50 = 0.5–7.0 μM) against both the cisplatin-sensitive and -resistant variants of the A2780 human ovarian carcinoma cell line, as well as against the A549 human lung carcinoma, K562 chronic myelogenous leukemia, and HeLa (human cervix carcinoma) cells. However, among the compounds studied, complex (2) showed the most promising biological properties: the highest stability in biologically relevant media, selectivity towards cancer cells over the non-cancer cells (HUVEC, human umbilical vein endothelial cells), and the highest inhibitory effect on cytosolic NADPH-dependent reductases in A2780 and A2780cis cells among the gold complexes under analysis.


2021 ◽  
Author(s):  
sevil şenkardeş ◽  
M.İhsan Han ◽  
Merve Gürboğa ◽  
Özlem Bingöl Özakpınar ◽  
Ş. Güniz Küçükgüzel

Abstract In the present study, the various 28 hybrid molecules containing hydrazone and sulfonate moiety were synthesized and characterized by FTIR, 1H-NMR, 13C-NMR spectroscopy and LC-MS spectrometry, besides elemental analysis. The compounds were evaluated for their antiproliferative effects against six cancer cell lines, namely A549 (non-small cell lung cancer), MCF-7 (breast cancer), HT-29 (colorectal adenocarcinoma cancer), PC-3 (androgen-independent prostate adenocarcinoma), Hep3B (hepatocellular carcinoma cancer), and HeLa (epitheloid cervix carcinoma cancer). Among all the target compounds, compounds 4g and 4h exhibited more promising effects on MCF-7 cell lines (IC50=17.8 mM and 21.2 mM, respectively) with high selectivity. Further mechanistic studies proposed that compounds 4g and 4h induced apoptosis is mediated through the intrinsic apoptotic pathway with changes in mitochondrial membrane potential by finally activating caspase-9 and caspase-3. The results have been encouraging enough to merit further investigation.


2021 ◽  
Author(s):  
Amritpal Kaur ◽  
Yash Sharma ◽  
Kamran Waidha ◽  
Madhumita P Ghosh ◽  
Anoop Kumar ◽  
...  

Abstract Abrus precatorius is a widely distributed tropical medicinal plant with several therapeutic properties, however its seed extract has not been studied against cervical cancer (CaCx) till date. Herein, we have assessed the antioxidant and antiproliferative properties of A. precatorius seed extracts (ethyl acetate and 70% ethanol) prepared from different extraction methods (Soxhlet and maceration) against human cervix carcinoma cells (Hep2C). We observed a significantly higher total flavonoid content of APE (sox) i.e.,112.7±0.127 mg Quercetin Equivalent/g of extract than others; total phenolic content of APA (mac) seed extract was higher i.e.,108.53±0.089 mg Quercetin Equivalent/g of extract and total tannin content of APA (sox) was higher i.e., 98.98± 0.011 mg tannic acid equivalents/g of extract. In addition, tannic acid, rutin and piperine were identified in extracts by HPLC. Furthermore, APA (sox) exhibited the highest radical scavenging activity with an IC50 value of 14.49±0.93µg/ml. APE (mac) showed the most significant antiproliferative activity with IC50 value of 85.90±0.93µg/mL against Hep2c cells. SOD and GST activity was observed as highest in the APA(Mac) extract whereas the catalase activity and GSH content was maximum in the APE(Mac) extract. Further, the MDA content was observed to be the least in APE(Mac) extracts. Docking results suggested maximum binding energy between tannic acid and Her2 receptor compared to doxorubicin (standard). This study provides evidence that A. precatorius seed extracts possess promising bioactive compounds with probable anticancer and antioxidant properties against CaCx which might be utilized as a possible herbal remedy aimed at restricting tumor growth.


Author(s):  
Hyder Osman Mirghani ◽  
Abdulmajeed Faisal Albalawi ◽  
Nawal Mohammed Alanazi ◽  
Dina Nasser Abusabir ◽  
Abrar Marwan Alamrani ◽  
...  

Background: Radiation dermatitis (RD) is a widespread complication of radiation therapy; however, there is still no agreement on the best treatment. The goal of this review is to go over how corticosteroids work throughout the treatment of radiation dermatitis. Methodology: A comprehensive evaluation of randomized controlled trials, retrospective and prospective studies involving topical corticosteroid (TC) for the treatment of radiation dermatitis. A thorough search was carried out in Medline, Embase, the Cochrane library, Clinical trials.gov, and Google scholar. The original search took place in August and was updated on September 2021. There were no restrictions on terminology or dates. Two reviewers independently examined each of the listed papers. A search of the relevant studies of all of the mentioned publications yielded additional papers. Results: We identified 19 studies on the role of corticosteroids for the prevention of radiation therapy. All the papers were published between 2001 and 2021. The total sample size of the included studies was 1974 with a mean sample size of 103.89. Among the included studies, four studies (21.05 %) represented head and neck cancer, 14 studies (73.68 %) were regarding breast cancer and 1 (5.26 %) hospital-based cross-sectional study represented multiple malignancies such as head and neck, breast and cervix carcinoma, respectively. Among all the participants, 1696 (85.91 %) were females while 278 (14.08 %) were males. Conclusion: Prophylactic treatment with TC was found to minimize the rate of RD and wet desquamation. Participants who used topical steroids reported improved symptoms and a higher quality of life, whereas the use of topical steroids during radiation had few side effects. ARD can be prevented using topical corticosteroids, based on these findings. As a result, further research must be done on the most effective TC to utilize during radiation.


2021 ◽  
Vol 14 (2) ◽  
pp. 11-15
Author(s):  
Mbasso Joseph Eric Tameko ◽  
Ngansop Raymond Nono ◽  
Marcel Frese ◽  
Jean Rodolphe Chouna ◽  
Ndjakou Bruno Lenta ◽  
...  

Phytochemical investigation of the stem bark extract of Psychotria djumaensis led to the isolation of ten known pentacyclic triterpenoids among which one lupane-, three oleanane-,  and six ursane-types. The structures of the isolated compounds were established by means of spectroscopic methods and by comparison with previously reported data. The isolated compounds were tested against five strains of bacteria, and the cytotoxicity against the human cervix carcinoma KB-3-1 cell was evaluated. The isolates exhibited weak antibacterial activity against the five strains. The cytotoxic activity exhibited by 3β,19α-dihydroxyurs-12-en-28-oic acid (5) (IC50 5.9 µM) was about three times more significant than that of the reference [(+) griseofulvin, IC50 17-21 µM].


2021 ◽  
Vol 14 (8) ◽  
pp. 782
Author(s):  
Xabier del Corte ◽  
Adrián López-Francés ◽  
Aitor Maestro ◽  
Ilia Villate-Beitia ◽  
Myriam Sainz-Ramos ◽  
...  

An efficient synthetic methodology for the preparation of 3-amino 1,5-dihydro-2H-pyrrol-2-ones through a multicomponent reaction of amines, aldehydes, and pyruvate derivatives is reported. In addition, the densely substituted lactam substrates show in vitro cytotoxicity, inhibiting the growth of carcinoma human tumor cell lines HEK293 (human embryonic kidney), MCF7 (human breast adenocarcinoma), HTB81 (human prostate carcinoma), HeLa (human epithelioid cervix carcinoma), RKO (human colon epithelial carcinoma), SKOV3 (human ovarian carcinoma), and A549 (carcinomic human alveolar basal epithelial cell). Given the possibilities in the diversity of the substituents that offer the multicomponent synthetic methodology, an extensive structure-activity profile is presented. In addition, both enantiomers of phosphonate-derived γ-lactam have been synthesized and isolated and a study of the cytotoxic activity of the racemic substrate vs. its two enantiomers is also presented. Cell morphology analysis and flow cytometry assays indicate that the main pathway by which our compounds induce cytotoxicity is based on the activation of the intracellular apoptotic mechanism.


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