Unusual cutaneous lesions in two patients with visceral leishmaniasis and HIV infection

1999 ◽  
Vol 41 (5) ◽  
pp. 847-850 ◽  
Author(s):  
Robert Colebunders ◽  
Katrien Depraetere ◽  
Thomas Verstraeten ◽  
Julian Lambert ◽  
Esther Hauben ◽  
...  
Keyword(s):  
Visceral Leishmaniasis ◽  
Hiv Infection ◽  
Cutaneous Lesions

scholarly journals Atypical Presentation of PKDL due toLeishmania infantumin an HIV-Infected Patient with Relapsing Visceral Leishmaniasis

2014 ◽  
Vol 2014 ◽  
pp. 1-3 ◽  
Author(s):  
Benedetto Maurizio Celesia ◽  
Bruno Cacopardo ◽  
Daniela Massimino ◽  
Maria Gussio ◽  
Salvatore Tosto ◽  
...  
Keyword(s):  
Visceral Leishmaniasis ◽  
Hiv Infection ◽  
Leishmania Infantum ◽  
Plasma Cells ◽  
Case Reports ◽  
Case Series ◽  
Skin Lesions ◽  
Secondary Prophylaxis ◽  
Complete Disappearance ◽  
Cutaneous Lesions

We describe the case of an Italian patient with HIV infection who developed an atypical rash resembling post-kala-azar dermal leishmaniasis (PKDL) when receiving liposomal Amphotericin B (L-AMB) for secondary prophylaxis of visceral leishmaniasis (VL). At the time of PKDL appearance, the patient was virologically suppressed but had failed to restore an adequate CD4+ T-cell count. Histology of skin lesions revealed the presence of a granulomatous infiltrate, with lymphocytes, plasma cells, and macrophages, most of which containedLeishmaniaamastigotes. Restriction fragment length polymorphism-polymerase chain reaction was positive forLeishmania infantum. Paradoxically, cutaneous lesions markedly improved when a new relapse of VL occurred. The patient received meglumine antimoniate, with a rapid clinical response and complete disappearance of cutaneous rash. Unfortunately, the patient had several relapses of VL over the following years, though the interval between them has become wider after restarting maintenance therapy with L-AMB 4 mg/kg/day once a month. Even if rare, PKDL due toLeishmania infantummay occur in Western countries and represents a diagnostic and therapeutic challenge for physicians. The therapeutic management of both PKDL and VL in HIV infection is challenging, because relapses are frequent and evidence is often limited to small case series and case reports.

Cutaneous lesions in patients with visceral leishmaniasis and HIV infection

1997 ◽  
Vol 35 (3) ◽  
pp. 265-268 ◽  
Author(s):  
C. Postigo ◽  
R. Llamas ◽  
C. Zarco ◽  
R. Rubio ◽  
F. Pulido ◽  
...  
Keyword(s):  
Visceral Leishmaniasis ◽  
Hiv Infection ◽  
Cutaneous Lesions

scholarly journals Evaluation of qPCR on blood and skin microbiopsies, peripheral blood buffy coat smear, and urine antigen ELISA for diagnosis and test of cure for visceral leishmaniasis in HIV-coinfected patients in India: a prospective cohort study

BMJ Open ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. e042519
Author(s):  
Sophie I Owen ◽  
Sakib Burza ◽  
Shiril Kumar ◽  
Neena Verma ◽  
Raman Mahajan ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Visceral Leishmaniasis ◽  
Hiv Infection ◽  
Peripheral Blood ◽  
Medical Science ◽  
Bone Marrow Aspiration ◽  
Buffy Coat ◽  
Tropical Medicine ◽  
Urine Antigen ◽  
Antigen Elisa

IntroductionHIV coinfection presents a challenge for diagnosis of visceral leishmaniasis (VL). Invasive splenic or bone marrow aspiration with microscopic visualisation of Leishmania parasites remains the gold standard for diagnosis of VL in HIV-coinfected patients. Furthermore, a test of cure by splenic or bone marrow aspiration is required as patients with VL-HIV infection are at a high risk of treatment failure. However, there remain financial, implementation and safety costs to these invasive techniques which severely limit their use under field conditions.Methods and analysisWe aim to evaluate blood and skin qPCR, peripheral blood buffy coat smear microscopy and urine antigen ELISA as non-invasive or minimally invasive alternatives for diagnosis and post-treatment test of cure for VL in HIV-coinfected patients in India, using a sample of 91 patients with parasitologically confirmed symptomatic VL-HIV infection.Ethics and disseminationEthical approval for this study has been granted by The Liverpool School of Tropical Medicine, The Institute of Tropical Medicine in Antwerp, the University of Antwerp and the Rajendra Memorial Research Institute of Medical Science in Patna. Any future publications will be published in open access journals.Trial registration numberCTRI/2019/03/017908.

scholarly journals The need for new therapeutic approaches in visceral leishmaniasis during HIV infection.

1990 ◽  
Vol 66 (779) ◽  
pp. 789-790 ◽  
Author(s):  
A. Lafeuillade ◽  
R. Quilichini ◽  
C. Dhiver ◽  
C. Mary ◽  
J. A. Gastaut
Keyword(s):  
Visceral Leishmaniasis ◽  
Hiv Infection ◽  
Therapeutic Approaches ◽  
New Therapeutic Approaches

scholarly journals Amastigota forms resembling Leishmania sp. on corneal ulceration in a dog: case report

2007 ◽  
Vol 59 (1) ◽  
pp. 81-84 ◽  
Author(s):  
F.L.C. Brito ◽  
L.C. Alves ◽  
F.C.L. Maia ◽  
A.R. Albuquerque ◽  
J.P.D. Ortiz ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Case Report ◽  
Visceral Leishmaniasis ◽  
Corneal Ulceration ◽  
Cutaneous Lesions

One dog with visceral leishmaniasis is reported presenting cutaneous lesions, cachexia, and corneal ulceration. Parasitological and serological diagnoses were performed by exam of contents of the aspirative punction of the bone marrow and by immunofluorecence, respectively. Amastigota forms resembling Leishmania sp. were visualized by citology.

HIV infection, visceral leishmaniasis and Guillain–Barré syndrome in the same patient: a case report

2008 ◽  
Vol 102 (2) ◽  
pp. 185-188 ◽  
Author(s):  
N. Kumar ◽  
K. Pandey ◽  
V. N. R. Das ◽  
P. K. Sinha ◽  
R. K. Topno ◽  
...  
Keyword(s):  
Case Report ◽  
Visceral Leishmaniasis ◽  
Hiv Infection ◽  
Guillain Barre Syndrome ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

scholarly journals Rapid Progression of Kaposi’s sarcoma complicated with hemophagocytic syndrome in a severely immunosuppressed patient with HIV-infection: a case report

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Pingzheng Mo ◽  
Liping Deng ◽  
Xiaoping Chen ◽  
Yong Xiong ◽  
Yongxi Zhang
Keyword(s):  
Hiv Infection ◽  
Kaposi's Sarcoma ◽  
Hemophagocytic Syndrome ◽  
Kaposi’S Sarcoma ◽  
Rapid Progression ◽  
Immunosuppressed Patient ◽  
Timely Manner ◽  
Cutaneous Lesions ◽  
Case Presentation ◽  
Life Threatening

Abstract Background AIDS-related KS generally involves cutaneous lesions, that slowly progress over months to years. Neither rapidly progressing of KS nor KS complicated with hemophagocytic syndrome (HPS) has rarely been reported. Case presentation We report a rare case of rapid progression of Kaposi’s sarcoma complicated with hemophagocytic syndrome in a severely immunosuppressed patient with HIV-infection. The symptoms of this patient were atypical, showing only persistent high fever and rapid progressed to hemophagocytic syndrome. This patient was successfully treated with antiretroviral therapy combined with liposomal doxorubicin. Conclusions The condition of the KS patient could deteriorate rapidly over a period of days and even developeded into HPS, which was life-threatening. However, chemotherapy initiated in a timely manner might improve prognosis.

Laryngeal leishmaniasis as initial opportunistic disease in HIV infection

1994 ◽  
Vol 108 (12) ◽  
pp. 1089-1092 ◽  
Author(s):  
Diego Luis Cánovas ◽  
Jaime Carbonell ◽  
Jose Torres ◽  
Jordi Altés ◽  
Juan Buades
Keyword(s):  
Visceral Leishmaniasis ◽  
Hiv Infection ◽  
Treatment Response ◽  
Clinical Features ◽  
Hiv Positive ◽  
Histological Findings ◽  
Opportunistic Disease ◽  
The Past ◽  
Endemic Areas

AbstractA case of laryngeal leishmaniasis, with symptoms of hoarseness and odinophagia which had developed over the past year, is presented. Clinical features and histological findings are discussed. Visceral leishmaniasis is increasingly associated with HIV infection and some authors have suggested the possibility of including it as a diagnostic criterium for AIDS in HIV-positive patients.When any case of leishmaniasis presents atypical clinical features, localization or treatment response in endemic areas, HIV infection should be ruled out.

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