Early-onset amyloid deposition in TGCRND8 mice expressing a mutant amyloid precursor protein transgene (APP695KM670/671NL + V717F)

2000 ◽  
Vol 21 ◽  
pp. 126
Author(s):  
M.Azhar Chrishti ◽  
Dun-Sheng Yang ◽  
Robert Strome ◽  
Patrick Horne ◽  
Donna Haskin ◽  
...  
Keyword(s):  
Amyloid Precursor Protein ◽  
Early Onset ◽  
Amyloid Deposition ◽  
Precursor Protein ◽  
Tgcrnd8 Mice

scholarly journals Early-onset Amyloid Deposition and Cognitive Deficits in Transgenic Mice Expressing a Double Mutant Form of Amyloid Precursor Protein 695

2001 ◽  
Vol 276 (24) ◽  
pp. 21562-21570 ◽  
Author(s):  
M. Azhar Chishti ◽  
Dun-Shen Yang ◽  
Christopher Janus ◽  
Amie L. Phinney ◽  
Patrick Horne ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Amyloid Precursor Protein ◽  
Cognitive Deficits ◽  
Early Onset ◽  
Double Mutant ◽  
Amyloid Deposition ◽  
Precursor Protein ◽  
Mutant Form

Exploring the Role of Aggregated Proteomes in the Pathogenesis of Alzheimer’s Disease

2020 ◽  
Vol 21 (12) ◽  
pp. 1164-1173
Author(s):  
Siju Ellickal Narayanan ◽  
Nikhila Sekhar ◽  
Rajalakshmi Ganesan Rajamma ◽  
Akash Marathakam ◽  
Abdullah Al Mamun ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Precursor Protein ◽  
Early Onset ◽  
Late Onset ◽  
Precursor Protein ◽  
Brain Disorder ◽  
Amyloid Aβ ◽  
T Tau

: Alzheimer’s disease (AD) is a progressive brain disorder and one of the most common causes of dementia and death. AD can be of two types; early-onset and late-onset, where late-onset AD occurs sporadically while early-onset AD results from a mutation in any of the three genes that include amyloid precursor protein (APP), presenilin 1 (PSEN 1) and presenilin 2 (PSEN 2). Biologically, AD is defined by the presence of the distinct neuropathological profile that consists of the extracellular β-amyloid (Aβ) deposition in the form of diffuse neuritic plaques, intraneuronal neurofibrillary tangles (NFTs) and neuropil threads; in dystrophic neuritis, consisting of aggregated hyperphosphorylated tau protein. Elevated levels of (Aβ), total tau (t-tau) and phosphorylated tau (ptau) in cerebrospinal fluid (CSF) have become an important biomarker for the identification of this neurodegenerative disease. The aggregation of Aβ peptide derived from amyloid precursor protein initiates a series of events that involve inflammation, tau hyperphosphorylation and its deposition, in addition to synaptic dysfunction and neurodegeneration, ultimately resulting in dementia. The current review focuses on the role of proteomes in the pathogenesis of AD.

scholarly journals Increased Extracellular Amyloid Deposition and Neurodegeneration in Human Amyloid Precursor Protein Transgenic Mice Deficient in Receptor-Associated Protein

2002 ◽  
Vol 22 (21) ◽  
pp. 9298-9304 ◽  
Author(s):  
Emily Van Uden ◽  
Margaret Mallory ◽  
Isaac Veinbergs ◽  
Michael Alford ◽  
Edward Rockenstein ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Amyloid Precursor Protein ◽  
Amyloid Deposition ◽  
Precursor Protein ◽  
Receptor Associated Protein

scholarly journals Interaction between amyloid precursor protein and Nogo receptors regulates amyloid deposition

2011 ◽  
Vol 25 (9) ◽  
pp. 3146-3156 ◽  
Author(s):  
Xiangdong Zhou ◽  
Xiangyou Hu ◽  
Wanxia He ◽  
Xiaoying Tang ◽  
Qi Shi ◽  
...  
Keyword(s):  
Amyloid Precursor Protein ◽  
Amyloid Deposition ◽  
Precursor Protein ◽  
Nogo Receptors
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