SUN-PP119: Leptin as a Diagnostic Marker of Cachexia Predict Survival in Pancreatic Cancer Patients

2015 ◽  
Vol 34 ◽  
pp. S67
Author(s):  
A. Saray ◽  
N. Vanis ◽  
S. Glavas ◽  
N. Zahiragic ◽  
R. Mesihovic
2022 ◽  
pp. 172460082110700
Author(s):  
Jia Chen ◽  
Dongting Yao ◽  
Weiqin Chen ◽  
Zhen Li ◽  
Yuanyuan Guo ◽  
...  

Objectives The aim of this study was to explore the diagnostic efficiency of serum exosomal miR-451a as a novel biomarker for pancreatic cancer. Methods Serum samples were collected prior to treatment. First, we analyzed microRNA (miRNA) profiles in serum exosomes from eight pancreatic cancer patients and eight healthy volunteers. We then validated the usefulness of the selected exosomal miRNAs as biomarkers in another 191 pancreatic cancer patients, 95 pancreatic benign disease (PB) patients, and 90 healthy controls. Results The expression of miR-451a in serum-derived exosomes from pancreatic cancer patients was significantly upregulated compared with those from PB patients and healthy individuals. Serum exosomal miR-451a showed excellent diagnostic power in identifying pancreatic cancer patients. In addition, exosomal miR-451a showed a significant association with clinical stage and distant metastasis in pancreatic cancer, and the expression level of serum exosomal miR-451a was sensitive to therapy and relapse. Conclusions Serum exosomal miR-451a might serve as a novel diagnostic marker for pancreatic cancer.


2020 ◽  
Author(s):  
L Archibugi ◽  
MC Petrone ◽  
G Rossi ◽  
A Mariani ◽  
SGG Testoni ◽  
...  

HPB ◽  
2021 ◽  
Vol 23 ◽  
pp. S233-S234
Author(s):  
F. van der Sijde ◽  
W. Dik ◽  
D. Mustafa ◽  
E. Vietsch ◽  
C. van Eijck

2021 ◽  
Vol 32 ◽  
pp. S350
Author(s):  
Tomoyo Oguri ◽  
Hiroyuki Takeda ◽  
Kumiko Umemoto ◽  
Ayako Doi ◽  
Hiroyuki Arai ◽  
...  

2021 ◽  
Vol 38 (2) ◽  
pp. 158-165
Author(s):  
Ilaria Pergolini ◽  
I. Ekin Demir ◽  
Christian Stöss ◽  
Klaus Emmanuel ◽  
Robert Rosenberg ◽  
...  

Background: This survey aimed to register changes determined by the COVID-19 pandemic on pancreatic surgery in a specific geographic area (Germany, Austria, and Switzerland) to evaluate the impact of the pandemic and obtain interesting cues for the future. Methods: An online survey was designed using Google Forms focusing on the local impact of the pandemic on pancreatic surgery. The survey was conducted at 2 different time points, during and after the lockdown. Results: Twenty-five respondents (25/56) completed the survey. Many aspects of oncological care have been affected with restrictions and delays: staging, tumor board, treatment selection, postoperative course, adjuvant treatments, outpatient care, and follow-up. Overall, 60% of respondents have prioritized pancreatic cancer patients according to stage, age, and comorbidities, and 40% opted not to operate high-risk patients. However, for 96% of participants, the standards of care were guaranteed. Discussion/Conclusions: The first wave of the COVID-19 pandemic had an important impact on pancreatic cancer surgery in central Europe. Guidelines for prompt interventions and prevention of the spread of viral infections in the surgical environment are needed to avoid a deterioration of care in cancer patients in the event of a second wave or a new pandemic. High-volume centers for pancreatic surgery should be preferred and their activity maintained. Virtual conferences have proven to be efficient during this pandemic and should be implemented in the near future.


HPB ◽  
2020 ◽  
Vol 22 ◽  
pp. S141
Author(s):  
K.E. Caldwell ◽  
C.W. Hammill ◽  
W.G. Hawkins ◽  
D.E. Sanford

2011 ◽  
Vol 137 (9) ◽  
pp. 1349-1361 ◽  
Author(s):  
Jörg-Christian Heinrich ◽  
Anne Tuukkanen ◽  
Michael Schroeder ◽  
Torsten Fahrig ◽  
Rudolf Fahrig

2010 ◽  
Vol 77 (4) ◽  
pp. 1171-1177 ◽  
Author(s):  
David T. Miyamoto ◽  
Harvey J. Mamon ◽  
David P. Ryan ◽  
Christopher G. Willett ◽  
Marek Ancukiewicz ◽  
...  

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