Rats with moderate renal failure show capillary deficit in heart but not skeletal muscle

A number of chronic illnesses such as renal failure (CRF), obstructive pulmonary disease, and congestive heart failure result in a significant decrease in exercise tolerance. There is an increasing awareness that prescribed exercise, designed to restore some level of physical performance and quality of life, can be beneficial in these conditions. In CRF patients, muscle function can be affected by a number of direct and indirect mechanisms caused by renal disease as well as various treatment modalities. The aims of this review are twofold: first, to briefly discuss the mechanisms by which CRF negatively impacts skeletal muscle and, therefore, exercise capacity, and, second, to discuss the available data on the effects of programmed exercise on muscle function, exercise capacity, and various other parameters in CRF.

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Plasma and Skeletal Muscle Free Aminoacids in Acute Renal Failure

Advances in Experimental Medicine and Biology - Acute Renal Failure ◽

10.1007/978-1-4684-8240-9_12 ◽

1987 ◽

pp. 93-98

Author(s):

Almerico Novarini ◽

Isabella Simoni ◽

Rossana Colla ◽

Antonio Trifirò ◽

Achille Guariglia ◽

...

Keyword(s):

Skeletal Muscle ◽

Renal Failure ◽

Acute Renal Failure ◽

Free Aminoacids

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Comparison of peripheral bone and body axis skeleton in a rat model of mild-to-moderate renal failure in the presence of physiological serum levels of calcitropic hormones

Bone ◽

10.1016/s8756-3282(01)00502-6 ◽

2001 ◽

Vol 29 (3) ◽

pp. 258-264 ◽

Cited By ~ 4

Author(s):

M.G Freesmeyer ◽

K Abendroth ◽

A Faldum ◽

C Krauss ◽

G Stein

Keyword(s):

Renal Failure ◽

Rat Model ◽

Serum Levels ◽

Body Axis ◽

Calcitropic Hormones ◽

Physiological Serum ◽

Moderate Renal Failure ◽

Peripheral Bone

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Alcohol Related Non-traumatic Rhabdomyolysis and Compartment Syndrome

Acute Medicine Journal ◽

10.52964/amja.0152 ◽

2007 ◽

Vol 6 (1) ◽

pp. 33-34

Author(s):

JPL Ong ◽

◽

LA Thomas ◽

Keyword(s):

Skeletal Muscle ◽

Renal Failure ◽

Acute Renal Failure ◽

Lower Extremity ◽

Compartment Syndrome ◽

Early Recognition ◽

Clinical Entity ◽

Threatening Condition ◽

Life Threatening ◽

Renal Support

Rhabdomyolysis is a serious and life-threatening condition in which skeletal muscle is damaged, commonly resulting in acute renal failure. The causes of this clinical entity can be traumatic and non-traumatic. In the latter group, alcohol is the commonest cause. This report describes the case of a 25 year old man who presented with rhabdomyolysis leading to acute renal failure after an alcohol binge. He presented with painful legs and lower extremity compartment syndrome. The patient recovered with surgical fasciotomy and renal support. This case illustrates the importance of early recognition and treatment of alcohol related non-traumatic rhabdomyolysis and compartment syndrome.

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Skeletal muscle digoxin binding in patients with renal failure.

British Journal of Clinical Pharmacology ◽

10.1111/j.1365-2125.1983.tb02153.x ◽

1983 ◽

Vol 16 (1) ◽

pp. 109-111 ◽

Cited By ~ 4

Author(s):

T Jogestrand ◽

F Ericsson

Keyword(s):

Skeletal Muscle ◽

Renal Failure ◽

Skeletal Muscle Digoxin

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Enhanced skeletal muscle arteriolar reactivity to ANG II after recovery from ischemic acute renal failure

AJP Regulatory Integrative and Comparative Physiology ◽

10.1152/ajpregu.00269.2005 ◽

2005 ◽

Vol 289 (6) ◽

pp. R1770-R1776 ◽

Cited By ~ 10

Author(s):

David P. Basile ◽

Deborah L. Donohoe ◽

Shane A. Phillips ◽

Jefferson C. Frisbee

Keyword(s):

Skeletal Muscle ◽

Renal Failure ◽

Acute Renal Failure ◽

Pressor Response ◽

Gracilis Muscle ◽

Ang Ii ◽

Sprague Dawley

In addition to the long-term renal complications, previous studies suggested that after acute renal failure (ARF), rats manifest an increased pressor response to an overnight infusion of ANG II. The present study tested whether recovery from ARF results in alterations in sensitivity to the peripheral vasculature. ARF was induced in Sprague-Dawley rats by 45 min of bilateral renal ischemia and reperfusion. Animals were allowed to recover renal structure and function for 5–8 wk, after which the acute pressor responses to ANG II were evaluated either in vivo in in situ skeletal muscle arterioles or in isolated gracilis muscle arteries in vitro. Baseline arterial pressure was not different in ARF rats vs. sham-operated controls, although ARF rats exhibited an enhanced pressor response to bolus ANG II infusion compared with control rats. Steady-state plasma ANG II concentration and plasma renin activity were similar between ARF and control rats. Constrictor reactivity of in situ cremasteric arterioles from ARF rats was enhanced in response to increasing concentrations of ANG II; however, no difference was observed in arteriolar responses to elevated Po2, norepinephrine, acetylcholine, or sodium nitroprusside. Isolated gracilis muscle arteries from ARF rats also showed increased vasoconstriction in response to ANG II but not norepinephrine. In conclusion, recovery from ischemic ARF is not associated with hypertension but is associated with increased arteriolar constrictor reactivity to ANG II. Although the mechanisms of this altered responsiveness are unclear, such changes may relate, in part, to cardiovascular complications in patients with ARF and/or after renal transplant.

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