Alcohol Related Non-traumatic Rhabdomyolysis and Compartment Syndrome

2007 ◽  
Vol 6 (1) ◽  
pp. 33-34
Author(s):  
JPL Ong ◽  
◽  
LA Thomas ◽  
Keyword(s):  
Skeletal Muscle ◽  
Renal Failure ◽  
Acute Renal Failure ◽  
Lower Extremity ◽  
Compartment Syndrome ◽  
Early Recognition ◽  
Clinical Entity ◽  
Threatening Condition ◽  
Life Threatening ◽  
Renal Support

Rhabdomyolysis is a serious and life-threatening condition in which skeletal muscle is damaged, commonly resulting in acute renal failure. The causes of this clinical entity can be traumatic and non-traumatic. In the latter group, alcohol is the commonest cause. This report describes the case of a 25 year old man who presented with rhabdomyolysis leading to acute renal failure after an alcohol binge. He presented with painful legs and lower extremity compartment syndrome. The patient recovered with surgical fasciotomy and renal support. This case illustrates the importance of early recognition and treatment of alcohol related non-traumatic rhabdomyolysis and compartment syndrome.

scholarly journals Contrast-Induced Rhabdomyolysis Occurring after ERCP in a Patient with Pancreatic Cancer: A Case Report

2020 ◽  
Author(s):  
Natassja Moriarty ◽  
Jonathan Moriarty ◽  
John Keating
Keyword(s):  
Skeletal Muscle ◽  
Pancreatic Cancer ◽  
Renal Failure ◽  
Creatine Kinase ◽  
Acute Renal Failure ◽  
Case Report ◽  
Mortality Rate ◽  
Appropriate Treatment ◽  
Threatening Condition ◽  
Life Threatening

Objective: We present a patient with pancreatic cancer who developed weakness, acute renal failure and significantly raised creatine kinase levels post-ERCP and who was assessed as having contrast-induced rhabdomyolysis. Results: The patient underwent haemofiltration and ultimately succumbed to his condition. Conclusion: Rhabdomyolysis is a potentially life-threatening condition which occurs because of damage to skeletal muscle, with release of myoglobin and electrolytes into the circulation. The mortality rate is 59% in severe cases, despite appropriate treatment.

scholarly journals Seven-Digit Creatine Kinase in Acute Rhabdomyolysis in a Child

2017 ◽  
Vol 4 ◽  
pp. 2329048X1668439 ◽  
Author(s):  
Nuha Basheer ◽  
Sirin Mneimneh ◽  
Mariam Rajab
Keyword(s):  
Renal Failure ◽  
Creatine Kinase ◽  
Acute Renal Failure ◽  
Creatine Kinase Level ◽  
Peak Plasma ◽  
Renal Dialysis ◽  
Acute Rhabdomyolysis ◽  
Threatening Condition ◽  
Life Threatening ◽  
Plasma Creatine Kinase

Rhabdomyolysis is an acute life-threatening condition that can occur in childhood secondary to many causes. The authors report the case of a 3-year-old male child who presented with acute rhabdomyolysis. The peak plasma creatine kinase level was extremely high. The 2 main causes of rhabdomyolysis in childhood are viral myositis and trauma, which can sometimes lead to acute renal failure. The highest creatine kinase levels reported in the literature so far was a 6-digit level in 2014 case report. In this study, the authors report the case of a 7-digit creatine kinase level in a child secondary to viral myositis who did not require renal dialysis.

scholarly journals Renal functional reserve by measuring the creatinine clearance in children : previously diagnosed and improved after acute renal failure

2015 ◽  
Vol 6 (1) ◽  
pp. 15-17
Author(s):  
Fahmuda Akhter ◽  
BH Nazma Yasmeen ◽  
Mohammad Hanif ◽  
Shushoma Roy
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Functional Reserve ◽  
Dialysis Unit ◽  
Renal Functional Reserve ◽  
Medical College ◽  
Stage 4 ◽  
Threatening Condition ◽  
Life Threatening ◽  
Stage 1

Background : Acute Renal Failure (ARF) is a life threatening condition causing significant morbidity and mortality in children. Many studies on adult ARF survivors showed that renal insufficiency persisted after an attack of ARF. Children may be more susceptible to this injury due to immaturity and ongoing growth of the kidney.Objective : This study was conducted to assess the renal functional reserve or detect any sign of renal injury in children after an episode of Acute Renal FailureMethods : This prospective study was carried out in the Renal and Dialysis unit, Dhaka Shishu Hospital in 2007, January . Thirty patients were enrolled in this study by searching data held in the study centre.Results : Thirty (30) patients were selected in this study. Among them 46.7% was in the group > 5-10 years, only 10.0% was in age group < 1 year and more than 10 years respectively. Male were 63.3%, female were 36.7%.Causes of acute renal failure were diarrhoea with dehydration 43.3%, septicaemia 20.0%, Haemolytic Uraemic Syndrome (HUS) 20%, Acute Glomerulo Nephrities (AGN) 10.0%, Henoch Schonlein Purpura ( HSP) 3.3% and hepato renal syndrome 3.3%. During follow up Glomerular Filtration Rate(GFR) of the patients were in stage 1 in 76.7% cases , 10.0% in stage 2, 6.7% in stage 3 stage and in stage 4 & 5 3.3% cases.23.3% patients were found with GFR between stage 2 to stage 5, who had ARF due to HUS and HSP. The incidence of hypertension and proteinuria was found in 13.3% cases of HUS.Conclusion : The progressive nature of acute renal failure which may cause chronic kidney disease is an important observation.Northern International Medical College Journal Vol.6(1) 2014: 15-17

Pretreatment Tumor Lysis Syndrome Associated with Bulky Retroperitoneal Tumors. Recognition is the Mainstay of Therapy

2006 ◽  
Vol 92 (6) ◽  
pp. 540-541
Author(s):  
Dimitrios Theodorou ◽  
Emmanuel Lagoudianakis ◽  
Michael Pattas ◽  
Panagiotis Drimousis ◽  
Dimitrios K Tsekouras ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Differential Diagnosis ◽  
Early Recognition ◽  
Rare Complication ◽  
Tumor Lysis Syndrome ◽  
Clinical Entity ◽  
Tumor Lysis ◽  
Aggressive Management ◽  
Retroperitoneal Tumors

Acute pretreatment tumor lysis syndrome is a rare complication of cancer. Early recognition and aggressive management are mandatory for prevention of the adverse sequelae of the syndrome. Here we present 2 cases of pretreatment tumor lysis syndrome, concluding that this clinical entity should be in the differential diagnosis of acute renal failure associated with malignancy, as early recognition is in fact the mainstay of treatment.

A rare case of rhabdomyolysis and acute renal failure following spinal surgery

2008 ◽  
Vol 9 (4) ◽  
pp. 387-389 ◽  
Author(s):  
Michael Papadakis ◽  
George Sapkas ◽  
Apostolos Tzoutzopoulos
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Spinal Surgery ◽  
Rare Case ◽  
Neurogenic Claudication ◽  
Intermittent Hemodialysis ◽  
Lumbar Surgery ◽  
Adequate Treatment ◽  
Threatening Condition ◽  
Life Threatening

Spinal surgery–associated rhabdomyolysis, although rare, is a life-threatening condition. Presented here is the case of a middle-aged, overweight man who underwent posterior lumbar surgery because of pain and neurogenic claudication. His postoperative course was complicated by the occurrence of rhabdomyolysis. Despite adequate treatment, acute renal failure developed as a sequela. His condition was grave enough to require the administration of intermittent hemodialysis. After a prolonged hospitalization and 5 sessions of hemodialysis, the patient achieved a full recovery. In view of the fact that rhabdomyolysis-induced acute renal failure is associated with a mortality rate of 20–50%, the outcome was favorable.

Ultrastructure of experimental crush injury in rats

1995 ◽  
Vol 53 ◽  
pp. 1002-1003
Author(s):  
Raymond Coleman ◽  
Ludmilla Mazor ◽  
Michael Silbermann ◽  
Irit Rubinstein ◽  
Ori S. Better
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Volcanic Eruptions ◽  
External Pressure ◽  
Muscle Pathology ◽  
Threatening Condition ◽  
Life Threatening ◽  
Muscle Breakdown ◽  
Basic Biology ◽  
Collapsed Building

Crush Syndrome is a potentially life-threatening condition that develops in humans trapped under debris of collapsed building such as occur in mass catastrophes such as earthquakes, volcanic eruptions and following explosions such as those of bombings or missile attacks. Traumatic pressure damage on limbs can result in myopathy and rhabdomyolysis. The consequences of muscle breakdown lead to major physiological disturbances and may result in acute renal failure if the condition is not recognised and dealt with as an emergency. Whereas there is now considerable progress in treating the condition, much less is known about the basic biology of the muscle pathology and the potential for repair of the traumatized muscle. In the present study we have developed a rat model in which controlled external pressure is used to mimic crush damage in humans, and we have followed the early stages of muscle damage and repair using histological and ultrastructural techniques.

scholarly journals Aortic Dissection and Renal Failure in a Patient with Severe Hypothyroidism

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Valerie Brooke ◽  
Sangeeta Goswami ◽  
Arpan Mohanty ◽  
Pashtoon Murtaza Kasi
Keyword(s):  
Renal Failure ◽  
Aortic Dissection ◽  
Early Recognition ◽  
False Lumen ◽  
Uncontrolled Hypertension ◽  
High Morbidity ◽  
Acute Type ◽  
Type B Dissection ◽  
Threatening Condition ◽  
Life Threatening

Acute aortic dissection (AAD) is a life-threatening condition associated with high morbidity and mortality. The most important recognized acquired cause that leads to dissection is chronic arterial hypertension. With respect to the anuria and renal failure, aortic dissection is not something that is always considered and is still not a very common presentation unless both renal arteries come off the false lumen of the dissection. However, when present, preoperative renal failure in patients with acute type B dissection has been noted to be an independent predictor of mortality. Early recognition and diagnosis is the key and as noted by previous studies as well, almost a third of these patients are initially worked up for other causes until later when they are diagnosed with aortic dissection. Here we present a case of a patient presenting with severe hypothyroidism, long-standing hypertension, and anuria. Through the case, we highlight the importance of having aortic dissection as an important differential in patients presenting with anuria who have a long standing history of uncontrolled hypertension. Pathophysiology relating to severe hypothyroidism-induced renal dysfunction is also discussed.

Rhabdomyolysis and Acute Renal Failure following an Ethanol and Diphenhydramine Overdose

2003 ◽  
Vol 37 (4) ◽  
pp. 538-542 ◽  
Author(s):  
Curtis E Haas ◽  
Yanina Magram ◽  
Archana Mishra
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Early Recognition ◽  
Drug Induced ◽  
Case Summary ◽  
Common Causes ◽  
Diphenhydramine Overdose ◽  
Life Threatening ◽  
High Index Of Suspicion ◽  
Oliguric Acute Renal Failure

OBJECTIVE: To report a case of nontraumatic rhabdomyolysis complicated by oliguric, acute renal failure following an intentional overdose of ethanol and diphenhydramine. CASE SUMMARY: A 21-year-old white man was admitted through the emergency department following an intentional overdose of ethanol and diphenhydramine. The patient subsequently developed acute renal failure, and a diagnosis of nontraumatic rhabdomyolysis was made. With the absence of other common causes in this case, the rhabdomyolysis was believed to be due to the combined ethanol and diphenhydramine overdose. DISCUSSION: Rhabdomyolysis is a severe and life-threatening syndrome caused by various insults to skeletal muscle, including drug-induced injury. Early detection and institution of effective treatments are essential to minimizing the complications of this syndrome. A delay in establishing the diagnosis in this case likely contributed to the severity of the renal failure. CONCLUSIONS: Nontraumatic rhabdomyolysis is an uncommon adverse outcome of drug and toxin ingestion. Due to the potential severity of the complications of this syndrome and the importance of early recognition and treatment to prevent renal failure, clinicians should have a high index of suspicion for rhabdomyolysis following overdoses that involve alcohol or antihistamines.

scholarly journals A clinical observational study in cases of eclampsia

2019 ◽  
Vol 8 (9) ◽  
pp. 3524
Author(s):  
Bipin Kanani ◽  
Nirav J. Garala
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Post Partum ◽  
Economic Status ◽  
Fetal Outcome ◽  
Adverse Outcomes ◽  
Tertiary Referral Centre ◽  
Threatening Condition ◽  
Life Threatening ◽  
Associated Risk Factors

Background: Eclampsia is a life threatening condition and one of the leading causes of maternal deaths worldwide. It is also associated with complications like acute renal failure, DIC, postpartum hemorrhage, etc. and adverse fetal outcomes.  Hence we aimed to study fetomaternal outcomes in cases of Eclampsia.Methods: A total of 75 cases of eclampsia out of 13524 deliveries were evaluated, from 1st January 2016 to 30th June 2017 at RZ Hospital, a government tertiary referral centre. Maternal outcomes were studied for its complications, effectiveness of magnesium sulphate treatment, fetal outcome and mode of delivery.Results: Incidence rate of eclampsia was 0.55%, 62.66% of all cases were primigravida, 76% of cases were in age group of 21-26 years, 84% cases were from lower socio economic status, maternal mortality occurred in 2 of 75 cases. 66.67% of patients were of term pregnancy (37 to 42 weeks). 71%(53) patients delivered vaginally out of which 9 deliveries were spontaneous and 44 deliveries were induced vaginal delivery. 22 patients required caesarean section.Conclusions: Early detection and prevention of pregnancy induced hypertension and pre-eclampsia and other associated risk factors for eclampsia might help to reduce the incidence of eclampsia. Maternal adverse outcomes in this study were magnesium toxicity, acute renal failure (ARF), disseminated intravascular coagulation (DIC) and post partum hemorrhage (PPH) while 92% patients had no complications.

scholarly journals Snakebites by Bothrops spp in children in Campinas, São Paulo, Brazil

2001 ◽  
Vol 43 (6) ◽  
pp. 329-333 ◽  
Author(s):  
Fábio BUCARETCHI ◽  
Sílvia Regina Fontoura HERRERA ◽  
Stephen HYSLOP ◽  
Emílio Carlos Elias BARACAT ◽  
Ronan José VIEIRA
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Compartment Syndrome ◽  
Blood Coagulation ◽  
Sao Paulo ◽  
Blood Coagulation Disorders ◽  
Local Infection ◽  
Coagulation Disorders ◽  
H2 Antagonists ◽  
Clinical Complications

From January, 1984 to March, 1999, 73 children under 15 y old (ages 1-14 y, median 9 y) were admitted after being bitten by snakes of the genus Bothrops. Twenty-six percent of the children were classified as mild envenoming, 50.7% as moderate envenoming and 20.6% as severe envenoming. Two patients (2.7%) showed no signs of envenoming. Most of the patients presented local manifestations, mainly edema (94.5%), pain (94.5%) ecchymosis (73.9%) and blisters (11%). Local and/or systemic bleeding was observed in 28.8% of the patients. Before antivenom (AV) administration, blood coagulation disorders were observed in 60.7% (incoagulable blood in 39.3%) of the 56 children that received AV only in our hospital. AV early reactions, most of which were considered mild, were observed in 44.6% of these cases (in 15/30 patients not pretreated and in 10/26 patients pretreated with hydrocortisone and histamine H1 and H2 antagonists). The main clinical complications observed were local infection (15.1%), compartment syndrome (4.1%), gangrene (1.4%) and acute renal failure (1.4%). No deaths were recorded. There were no significant differences with regard to severity of envenoming versus the frequency of blood coagulation disorders among the three categories of envenoming (p = 0.75) or in the frequency of patients with AV early reactions between the groups that were and were not pretreated (p = 0.55). The frequency of local infection was significantly greater in severe cases (p < 0.001). Patients admitted more than 6 h after the bite had a higher risk of developing severe envenoming (p = 0.04).

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