Outcomes of oral squamous cell carcinoma in Taiwan after surgical therapy: factors affecting survival

Abstract Objectives Survival for patients with recurrent oral squamous cell carcinoma is usually poor, and the most effective treatment has not yet been clearly defined. The present study evaluates the outcome in radiotherapy-naïve patients after recurrence of oral squamous cell carcinoma with respect to different treatment modalities including surgery, radiation, chemoradiation, and palliative treatment. Patients and methods In this retrospective study, we included all patients with primary oral squamous cell carcinoma who received exclusively surgical therapy between 2010 and 2020 and who suffered from locoregional recurrence in their follow-up. Patients with previous adjuvant therapy were excluded from this protocol. Clinical and pathological parameters were collected and statistically evaluated. Survival analysis was performed according to Kaplan–Meier. The primary endpoints were overall and progression-free survival in dependance of treatment strategy for recurrent tumors. Results Out of a total of 538 patients with surgically treated primary oral squamous cell carcinoma, 76 patients met the inclusion criteria. The mean follow-up was 38 ± 32 months. Patients who received surgically based therapy had a significantly better outcome in terms of disease-free survival (DFS) and overall survival (OS) (DFS p < 0.001; OS p < 0.001). The presence of regional metastases and a short disease-free interval (DFI) between primary and recurrent cancer were significant predictors for adverse outcomes (DFI p < 0.001). Conclusion We recommend primary surgical therapy for radiotherapy-naïve patients with recurrent oral squamous cell carcinoma, supplemented by risk-adapted adjuvant therapy. Clinical relevance Surgical therapy continues to play a central role in the treatment of radiotherapy-naïve patients with recurrent oral squamous cell carcinoma.

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Oral squamous cell carcinoma involving the maxillae: Factors affecting local recurrence and the value of salvage treatment for overall survival

Head & Neck ◽

10.1002/hed.26108 ◽

2020 ◽

Vol 42 (8) ◽

pp. 1821-1828

Author(s):

Fons J. B. Slieker ◽

Remco Bree ◽

Ellen M. Van Cann

Keyword(s):

Overall Survival ◽

Squamous Cell Carcinoma ◽

Local Recurrence ◽

Oral Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Salvage Treatment ◽

Factors Affecting

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Assessment of Factors Affecting Quality of Life in Oral Squamous Cell Carcinoma Patients Using University of Washington Quality of Life Questionnaire

Cureus ◽

10.7759/cureus.3904 ◽

2019 ◽

Cited By ~ 1

Author(s):

Syed A Abbas ◽

Muhammad Usman U Tariq ◽

Ahmed Raheem ◽

Javeria Saeed ◽

Syed S Hashmi ◽

...

Keyword(s):

Quality Of Life ◽

Squamous Cell Carcinoma ◽

Oral Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Life Questionnaire ◽

University Of Washington ◽

Factors Affecting ◽

Quality Of Life Questionnaire

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Clinical profile of the patients with oral squamous cell carcinoma: a tertiary institutional study

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20201002 ◽

2020 ◽

Vol 6 (4) ◽

pp. 628

Author(s):

Deep Jyoti ◽

Arti . ◽

Padam Jamwal ◽

Sonika Kotwal ◽

Kunzes Dolma

Keyword(s):

Squamous Cell Carcinoma ◽

Oral Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Economic Status ◽

Young Generation ◽

Chewing Tobacco ◽

Female Ratio ◽

Factors Affecting ◽

Oral Neoplasms

Background: Oral cancer consists of a group of neoplasms affecting any region of the oral cavity. This term is commonly used interchangeably with oral squamous cell carcinoma (OSCC), representing the most frequent of all oral neoplasms. Factors affecting the development of the oral squamous cell carcinoma are tobacco use, alcohol consumption, low socio-economic status, poor hygiene, poor diet, viral infection like HPV, ill-fitting dentures, jagged teeth.Methods: An institution based retrospective observational study was conducted in the department of ENT, GMC Jammu, including the records of the patients with oral squamous cell carcinoma admitted from June 2016 to July 2019. 80 patients of oral carcinoma were included in the study.Results: Male to female ratio was 5.1:1. Mean age of presentation was 49.2±4.1 with most of the cases presenting in the 6th decade. 27 (33.75%) patients had history of chewing tobacco alone, 17 (21%) had smoking with chewing tobacco and 10 (12.5 %) smoking with alcohol. 52% patients presented with growth of tongue (52%) followed by buccal mucosa (17.5%) and other sites. Histopathological grading of OSCC showed predominance of well differentiated cancer in 44 cases (55%).Conclusions: Cases of OSCC are increasing day by day in young generation due to increasing exposure to the risk habits which are easily accessible to them.

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Long Noncoding RNAs in the Metastasis of Oral Squamous Cell Carcinoma

Frontiers in Oncology ◽

10.3389/fonc.2020.616717 ◽

2021 ◽

Vol 10 ◽

Author(s):

Yuming Xu ◽

Erhui Jiang ◽

Zhe Shao ◽

Zhengjun Shang

Keyword(s):

Squamous Cell Carcinoma ◽

Oral Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Rna Stability ◽

Chromatin Modification ◽

Noncoding Rnas ◽

Mrna Translation ◽

Long Noncoding Rnas ◽

Factors Affecting

Oral squamous cell carcinoma (OSCC) is a common malignant tumor worldwide. Metastasis is the main cause of the death of OSCC patients. Long noncoding RNAs (lncRNAs), one of the key factors affecting OSCC metastasis, are a subtype of RNA with a length of more than 200 nucleotides that has little or no coding potential. In recent years, the important role played by lncRNAs in biological processes, such as chromatin modification, transcription regulation, RNA stability regulation, and mRNA translation, has been gradually revealed. More and more studies have shown that lncRNAs can regulate the metastasis of various tumors including OSCC at epigenetic, transcriptional, and post-transcriptional levels. In this review, we mainly discussed the role and possible mechanisms of lncRNAs in OSCC metastasis. Most lncRNAs act as oncogenes and only a few lncRNAs have been shown to inhibit OSCC metastasis. Besides, we briefly introduced the research status of cancer-associated fibroblasts-related lncRNAs in OSCC metastasis. Finally, we discussed the research prospects of lncRNAs-mediated crosstalk between OSCC cells and the tumor microenvironment in OSCC metastasis, especially the potential research value of exosomes and lymphangiogenesis. In general, lncRNAs are expected to be used for screening, treatment, and prognosis monitoring of OSCC metastasis, but more work is still required to better understand the biological function of lncRNAs.

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