Factors affecting surgical mortality of oral squamous cell carcinoma resection

Background: Oral cancer consists of a group of neoplasms affecting any region of the oral cavity. This term is commonly used interchangeably with oral squamous cell carcinoma (OSCC), representing the most frequent of all oral neoplasms. Factors affecting the development of the oral squamous cell carcinoma are tobacco use, alcohol consumption, low socio-economic status, poor hygiene, poor diet, viral infection like HPV, ill-fitting dentures, jagged teeth.Methods: An institution based retrospective observational study was conducted in the department of ENT, GMC Jammu, including the records of the patients with oral squamous cell carcinoma admitted from June 2016 to July 2019. 80 patients of oral carcinoma were included in the study.Results: Male to female ratio was 5.1:1. Mean age of presentation was 49.2±4.1 with most of the cases presenting in the 6th decade. 27 (33.75%) patients had history of chewing tobacco alone, 17 (21%) had smoking with chewing tobacco and 10 (12.5 %) smoking with alcohol. 52% patients presented with growth of tongue (52%) followed by buccal mucosa (17.5%) and other sites. Histopathological grading of OSCC showed predominance of well differentiated cancer in 44 cases (55%).Conclusions: Cases of OSCC are increasing day by day in young generation due to increasing exposure to the risk habits which are easily accessible to them.

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Long Noncoding RNAs in the Metastasis of Oral Squamous Cell Carcinoma

Frontiers in Oncology ◽

10.3389/fonc.2020.616717 ◽

2021 ◽

Vol 10 ◽

Author(s):

Yuming Xu ◽

Erhui Jiang ◽

Zhe Shao ◽

Zhengjun Shang

Keyword(s):

Squamous Cell Carcinoma ◽

Oral Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Rna Stability ◽

Chromatin Modification ◽

Noncoding Rnas ◽

Mrna Translation ◽

Long Noncoding Rnas ◽

Factors Affecting

Oral squamous cell carcinoma (OSCC) is a common malignant tumor worldwide. Metastasis is the main cause of the death of OSCC patients. Long noncoding RNAs (lncRNAs), one of the key factors affecting OSCC metastasis, are a subtype of RNA with a length of more than 200 nucleotides that has little or no coding potential. In recent years, the important role played by lncRNAs in biological processes, such as chromatin modification, transcription regulation, RNA stability regulation, and mRNA translation, has been gradually revealed. More and more studies have shown that lncRNAs can regulate the metastasis of various tumors including OSCC at epigenetic, transcriptional, and post-transcriptional levels. In this review, we mainly discussed the role and possible mechanisms of lncRNAs in OSCC metastasis. Most lncRNAs act as oncogenes and only a few lncRNAs have been shown to inhibit OSCC metastasis. Besides, we briefly introduced the research status of cancer-associated fibroblasts-related lncRNAs in OSCC metastasis. Finally, we discussed the research prospects of lncRNAs-mediated crosstalk between OSCC cells and the tumor microenvironment in OSCC metastasis, especially the potential research value of exosomes and lymphangiogenesis. In general, lncRNAs are expected to be used for screening, treatment, and prognosis monitoring of OSCC metastasis, but more work is still required to better understand the biological function of lncRNAs.

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From molecular diagnostics to molecular targeted therapy with natural product small molecule inhibitors in oral squamous cell carcinoma

Planta Medica ◽

10.1055/s-2007-986722 ◽

2007 ◽

Vol 73 (09) ◽

Cited By ~ 1

Author(s):

VB Konkimalla ◽

VL Suhas ◽

NR Chandra ◽

E Gebhart ◽

T Efferth

Keyword(s):

Squamous Cell Carcinoma ◽

Targeted Therapy ◽

Oral Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Natural Product ◽

Molecular Diagnostics ◽

Small Molecule ◽

Squamous Cell ◽

Molecular Targeted Therapy ◽

Small Molecule Inhibitors

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Role of Clinical Palpation in Evaluation of Cervical Lymph Node in Oral Squamous Cell Carcinoma

Update Dental College Journal ◽

10.3329/updcj.v1i2.13978 ◽

2013 ◽

Vol 1 (2) ◽

pp. 02-06

Author(s):

SM Anwar Sadat ◽

Sufia Nasrin Rita ◽

Shoma Banik ◽

Md Nazmul Hasan Khandker ◽

Md Mahfuz Hossain ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Lymph Node ◽

Oral Squamous Cell Carcinoma ◽

Lymph Nodes ◽

Cell Carcinoma ◽

Squamous Cell ◽

Predictive Value ◽

Cervical Lymph Node ◽

Betel Quid ◽

Cervical Lymph Nodes

A cross sectional study of 29 cases of oral squamous cell carcinoma with or without cervical lymph node metastasis was done among Bangladeshi patients from January 2006 to December 2007. Majority of the study subjects (34.5%) belonged to the age group of 40-49 years. 58.6% of the study subjects were male, while remaining 41.4% of them were female. 51.7% of the lesions were located in the alveolar ridge where the other common sites were buccal mucosa (27.6%) and retro molar area (13.8%). Half of the study subjects (51.7%) were habituated to betel quid chewing followed by 37.9% and 10.3% were habituated to smoking and betel quid-smoking respectively. Grade I lesions was most prevalent (75.9%) in the study subjects. Majority of cases presented with Stage IV lesions (55.2%). The sensitivity, specificity, positive predictive value, negative predictive value & accuracy of clinical palpation method for determining metastatic cervical lymph nodes were 93.33%, 64.29%, 73.68%, 90% and 79.3% respectively. Careful and repeated clinical palpation plays important role in evaluation of cervical lymph nodes though several modern techniques may help additionally in the management of oral cancer.DOI: http://dx.doi.org/10.3329/updcj.v1i2.13978 Update Dent. Coll. j. 2011: 1(2): 02-06

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Management of Neck in Oral Squamous Cell Carcinoma

Indian Journal Of Applied Research ◽

10.15373/2249555x/june2013/140 ◽

2011 ◽

Vol 3 (6) ◽

pp. 419-422

Author(s):

Dr. Shool Rohit S Dr. Shool Rohit S ◽

◽

Dr. Anand P Zingade ◽

Dr. Manish Kumar

Keyword(s):

Squamous Cell Carcinoma ◽

Oral Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell

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