Vaccine Effect Might Depend on Needle Length

2008 ◽  
Vol 38 (23) ◽  
pp. 18
Author(s):  
HEIDI SPLETE
Keyword(s):  
2020 ◽  
Vol 14 (1) ◽  
pp. 46-55 ◽  
Author(s):  
Zhi Liu ◽  
Lei Zhou ◽  
Fangtao Ruan ◽  
Anfang Wei ◽  
Jianghui Zhao ◽  
...  

Background: Nanofiber’s productivity plagues nanofibrous membranes’ applications in many areas. Herein, we present the needle-disk electrospinning to improve throughput. In this method, multiple high-curvature mentals are used as the spinning electrode. Methods: Three aspects were investigated: 1) mechanism elucidation of the needle-disk electrospinning; 2) parameter optimization of the needle-disk electrospinning; 3) productivity improvement of the needle-disk electrospinning. Results: Results show that high-curvature electrode evokes high electric field intensity, making lower voltage supply in spinning process. The needle number, needle length and needle curvature synergistically affect the spinning process and nanofiber morphology. Additionally, higher disk rotation velocity and higher voltage supply can also result in higher nanofiber’s productivity. Conclusion: Compared with previous patents related to this topic, the needle-disk electrospinning is featured with the merits of high throughput, low voltage supply, controllable spinning process and nanofiber morphology, benefiting the nanofiber practical industrial employment and further applications of nanofiber-based materials.


2015 ◽  
Vol 28 (4) ◽  
pp. 264-267 ◽  
Author(s):  
K. S. O'Neal ◽  
J. Johnson ◽  
S. Swar
Keyword(s):  

1994 ◽  
Vol 24 (1) ◽  
pp. 61-70 ◽  
Author(s):  
Conor O'Reilly ◽  
J.N. Owens ◽  
J.T. Arnott ◽  
B.G. Dunsworth

Western hemlock (Tsugaheterophylla (Raf.) Sarg.) seedlings grown in two different container cavities that received four different dormancy induction treatments, short (SD) or long days (LD) in combination with moisture stress (D) or no stress (W) in the greenhouse, and lifted and placed in cold storage (November, January, or March), were planted on two adjacent coastal reforestation sites in British Columbia and monitored for survival and morphological development. Survival was greatest in seedlings grown in the larger cavities in the greenhouse, in seedlings lifted in March, and in seedlings not treated to moisture stress. Seedling shoots had more stem units on the southeast than the northwest site, but the amount varied with nursery treatment. Seedlings from the LD treatments produced more stem units during free growth and lammas growth than those from the SD treatment. Nevertheless, most shoot growth was predetermined in the buds during nursery culture, accounting for a minimum of 67% of the final number of stem units. Stem unit length (SUL) was longer in seedlings on the southeast site than on the northwest site for those treated to LD in the nursery. Seedlings treated to short days showed the reverse pattern (SDW) to this, or were unaffected by site (SDD). Shoots and needles were shortest for seedlings from the SDD treatment and for those lifted in November. Shoot growth was greatest for seedlings lifted in March and for those treated with LD, mainly owing to their longer SUL. Lammas growth was most frequent in seedlings from the smaller cavities, and in those from the November and March lifts.


2021 ◽  
Author(s):  
Danyu Lin ◽  
Donglin Zeng ◽  
Yu Gu ◽  
Thomas Fleming ◽  
Phillip Krause

Decision-making about booster dosing for COVID-19 vaccine recipients hinges on reliable methods for evaluating the longevity of vaccine protection. We show that modeling of protection as a piecewise linear function of time since vaccination for the log hazard ratio of the vaccine effect provides more reliable estimates of vaccine effectiveness at the end of an observation period and also more reliably detects plateaus in protective effectiveness as compared with the traditional method of estimating a constant vaccine effect over each time period. This approach will be useful for analyzing data pertaining to COVID-19 vaccines and other vaccines where rapid and reliable understanding of vaccine effectiveness over time is desired.


2000 ◽  
Vol 125 (2) ◽  
pp. 393-397 ◽  
Author(s):  
Y. DEGUCHI ◽  
Y. TAKASUGI ◽  
K. NISHIMURA

Influenza vaccine effect on the occurrence and severity of influenza virus infection in a population residing in nursing homes for the elderly was studied as a cohort study during an influenza A (H3N2) epidemic in Japan. Of 22462 individuals living in 301 welfare nursing homes, 10739 voluntarily received inactivated, sub-unit trivalent influenza vaccine in a programme supported by the Osaka Prefectural Government. There were statistically significantly fewer cases of influenza, hospital admissions due to severe infection, and deaths due to influenza in the vaccinated cohort compared to the unvaccinated controls. No serious adverse reactions to vaccination were recorded. Thus influenza vaccination is effective for preventing influenza disease in persons aged 65 years and over, and should be an integral part of the care of this population residing in nursing homes.


Heliyon ◽  
2020 ◽  
Vol 6 (6) ◽  
pp. e04301
Author(s):  
Atsushi Kawai ◽  
Yasuyuki Yamamoto ◽  
Yasuo Yoshioka

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