The aim of the present study was to investigate the co-effect produced by water-soluble form of quercetin and SR 11302, an inhibitor of AP-1 transcription factor, on biochemical depolymerization markers of periodontal organic matrix during systemic and local administration of S. typhi lipopolisaccharide (LPS). The studies were conducted on 25 white rats of the Wistar line weighing 180-220 g, divided into 5 groups: the 1st group included the intact animals, the 2nd group was made up of the animals subject to the combined systemic and local LPS administration, the 3rd and 4th groups included animals, which were given injections with water-soluble form of quercetin (10 mg / kg) and AP-1 activation inhibitor SR 11302 (1 mg / kg) respectively 3 times a week starting on the 30th day of the systemic LPS administration, and the 5th group involved rats, which were injected with co-administered water-soluble form of quercetin and SR 11302. It has been found out the the quercetin and SR 11302 co-administration during systemic and local LPS administration is accompanied with reduced concentration of free hydroxyproline and N-acetylneuraminic acid (NANA) in the soft and bone tissues of the periodontium compared with the results obtained during the separate administration of these agents. The content of glycosaminoglycans did not change. We can suggest that the co-administration of the water-soluble form of quercetin and SR 11302, the AP-1 activation inhibitor, during systemic and local administration of the S. typhi lipopolysaccharide is a more effective means of correcting disorders of the periodontal connective tissue than when the agents are used separately.
Treatment of transplanted rat tumours with double-stranded RNA (BRL 5907). I. Influence of systemic and local administration