Chapter 14 Quantitative Analysis By Gas Chromatography Response Factors. Determination. Accuracy and Precision

1988 ◽  
pp. 587-627
Keyword(s):  
Gas Chromatography ◽  
Quantitative Analysis ◽  
Response Factors ◽  
Accuracy And Precision

scholarly journals Nitrogen-containing aromatic compounds: quantitative analysis using gas chromatography with nitrogen phosphorus detector

2021 ◽  
Author(s):  
Yuan Rao ◽  
Arno de Klerk
Keyword(s):  
Gas Chromatography ◽  
Quantitative Analysis ◽  
Aromatic Compounds ◽  
Process Development ◽  
Complex Mixtures ◽  
Response Factors ◽  
Cyanide Anion ◽  
Nitrogen Phosphorus Detector ◽  
Assurance Process ◽  
Nitrogen Containing Compounds

AbstractThe nitrogen-containing aromatic compounds found in the petrochemical industry are varied and extend beyond classes such as the anilines, pyrroles and pyridines. Quantification of these nitrogen-containing compounds that may occur in complex mixtures has practical application for quality assurance, process development and the evaluation of conversion processes. Selective detection of nitrogen-containing species in complex mixtures is possible by making use of gas chromatography coupled with a nitrogen phosphorous detector (GC-NPD), which is also called a thermionic detector. Despite the linearity of the NPD response to individual nitrogen-containing compounds, the response factor is different for different compounds and even isomers of the same species. Quantitative analysis using an NPD requires species-specific calibration. The reason for the sensitivity of the NPD to structure is related to the ease of forming the cyano-radical that is ionized to the cyanide anion, which is detected. The operation of the NPD was related to the processes of pyrolysis and subsequent ionization. It was possible to offer plausible explanations for differences in response factors for isomers based on pyrolysis chemistry. Due to this relationship, the NPD response can in the same way be used to provide information of practical relevance beyond its analytical value and a few possible applications were outlined.

scholarly journals Determination of dimethoxyphenethylamine derivatives in urine by deuterium labeled internal standards

2008 ◽  
Vol 73 (12) ◽  
pp. 1223-1233 ◽  
Author(s):  
Ya-Zhu Xu ◽  
Huei-Ru Lin ◽  
Ahai-Chang Lua ◽  
Chinpiao Chen
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Quantitative Analysis ◽  
Forensic Analysis ◽  
Gas Chromatography Mass Spectrometry ◽  
Selected Ion Monitoring ◽  
Internal Standards ◽  
Chromatography Mass Spectrometry ◽  
Accuracy And Precision

The use of gas chromatography-mass spectrometry (GC-MS) in forensic analysis is increasing. To exploit fully the capabilities of MS, labeled standards, that can be used to improve the performance of the quantitative analysis, and to increase accuracy and precision, are required. A series of deuterated internal standards, corresponding to the 2C-series of phenethylamine derivatives, including 4-bromo-2,5-dimethoxyphenethylamine-d6 (2C-B), 4-chloro- 2,5-dimethoxyphenethylamine-d6 (2C-C), 4-iodo-2,5-dimethoxy-phenethylamine-d6 (2C-I), 4-ethylthio-2,5-dimethoxy-phenethylamine-d6 (2C-T-2) and 2,5-dimethoxy-4-n-propylthiophenethylamine-d6 (2C-T-7), were synthesized. These deuterated compounds were used to analyze for the corresponding unlabeled compounds in urine. The analysis was performed using GC-MS, with the selected ion monitoring (SIM) technique, whereby good results were achieved.

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