SPMP 8105 The focal lesions of thyroid gland evaluated by Color Doppler

The occurrence of focal lesions in the thyroid gland affects up to 65% of the general population, and an important element of diagnostics is the most precise possible distinction between benign and malignant lesions. Despite advanced knowledge and developed algorithms, in some cases the decision to proceed further may cause problems even for an experienced clinician. A promising tool in estimating oncological risk is sonoelastography. This article aims to approximate and organize knowledge in this field in relation to focal lesions of the thyroid gland and to encourage the implementation of the method in everyday practice.

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Diagnosis

Diagnosing and Managing Hashimoto’s Disease - Advances in Medical Diagnosis, Treatment, and Care ◽

10.4018/978-1-5225-9655-4.ch007 ◽

2020 ◽

pp. 88-98

Keyword(s):

Thyroid Gland ◽

Subclinical Hypothyroidism ◽

Color Doppler ◽

Thyroid Stimulating Hormone ◽

Thyroglobulin Antibodies ◽

Lymphoid Follicles ◽

Pyramidal Lobe ◽

Glandular Enlargement ◽

Thyroid Parenchyma ◽

Sensitive Marker

Clinically, a diffuse, firm goiter with pyramidal lobe enlargement, and without signs of thyrotoxicosis, should suggest the diagnosis of Hashimoto's thyroiditis (HT). The association of goiter with hypothyroidism is almost diagnostic. The thyroid stimulating hormone (TSH) is the sensitive marker of hypothyroidism and diagnosis of subclinical hypothyroidism. Thyroid perioxidase antibodies (TPO-Ab) and, less frequently, thyroglobulin antibodies (Tg-Ab) are elevated in the serum of patients with HT. Ultrasound may display an enlarged gland with normal texture, focal, or diffuse glandular enlargement with coarse, heterogenous, and hypo-echoic pattern, or a suggestion of multiple ill-defined micro-nodules. Color Doppler shows extensive hyper-vascularity. Histologically, the thyroid gland shows diffuse lymphocytic and plasma cell infiltration with formation of lymphoid follicles. Atrophy of the thyroid parenchyma is usually evident. It also reveals scant colloid, and a few epithelial cells, which may show Hurthle cell change. This chapter explores the diagnosis of Hashimoto's disease.

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A Case of Marine-Lenhart Syndrome with a Negative TSH Receptor Antibody Titer Successfully Treated with a Fixed, Low Dose of I131

Case Reports in Endocrinology ◽

10.1155/2014/423563 ◽

2014 ◽

Vol 2014 ◽

pp. 1-4 ◽

Cited By ~ 1

Author(s):

Masahiro Takei ◽

Hiroaki Ishii ◽

Yoshihiko Sato ◽

Mitsuhisa Komatsu

Keyword(s):

Thyroid Gland ◽

Antibody Titer ◽

Color Doppler ◽

Laboratory Data ◽

Tsh Receptor ◽

Thyroid Peroxidase ◽

Graves Disease ◽

Receptor Antibody ◽

Tsh Receptor Antibody ◽

The Right

We herein describe a case of Marine-Lenhart syndrome with a negative TSH receptor antibody titer. A 75-year-old female presented to our hospital with malaise, palpitations, and mild fine tremors. She did not have any signs suggestive of Graves’ ophthalmopathy, including conjunctival injection, periorbital edema, or proptosis. Her laboratory data were negative for thyroid autoantibodies, including anti-thyroid peroxidase antibodies, anti-thyroglobulin antibodies, and anti-TSH receptor antibodies (TRAb). Ultrasonography of the thyroid gland revealed a tumor in the right lobe. The remaining thyroid gland had an inhomogeneous and rough texture with a high color Doppler flow. I123scintigraphy disclosed a hot nodule in the right thyroid gland corresponding to the tumor detected on ultrasonography, suggesting Plummer disease. Furthermore, there was an increased uptake of radionuclide in the rest of the thyroid gland, despite the suppressed level of TSH and negative titer of TRAb, suggesting underlying Graves’ disease. The present findings suggested a diagnosis of Marine-Lenhart syndrome with a negative TRAb titer. Treatment with 10 mCi of radioiodine was highly effective in treating hyperthyroidism in this case. A negative TSH receptor antibody titer does not necessarily rule out the existence of Graves’ disease in patients with Plummer disease.

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Assessment of Inferior Thyroid Artery by Color Doppler Ultrasound in Diffuse Toxic GoiterExperience at NINMAS

Bangladesh Journal of Nuclear Medicine ◽

10.3329/bjnm.v20i1.36854 ◽

2018 ◽

Vol 20 (1) ◽

pp. 41

Author(s):

Nasreen Sultana ◽

Sharmin Quddus ◽

Rahima Perveen ◽

Mohammad Simoon Salekin ◽

Md Bashir ◽

...

Keyword(s):

Blood Flow ◽

Thyroid Gland ◽

Radioiodine Therapy ◽

Color Doppler ◽

Peak Systolic Velocity ◽

Inferior Thyroid Artery ◽

Group A ◽

Group B ◽

Toxic Goiter ◽

Anterior Posterior

Objective: The aim of this study was to compare the B mode ultrasonography findings of thyroid gland and peak systolic velocity of inferior thyroid artery by color Doppler application, in patients with diffuse toxic goiter at the time of diagnosis and 6-8 months after radioiodine 131-I therapy.Patients and Methods: This was a prospective observational study conducted in National Institute of Nuclear Medicine & Allied Sciences (NINMAS) between June 2015 and October 2016. Forty consecutive diagnosed diffuse toxic goiter patients were selected at the time of diagnosis prior to radioiodine therapy. An ultrasonography evaluation of thyroid gland (measurement of anterior posterior diameter for convenience) and measurement of peak systolic velocity of inferior thyroid artery in both sides of thyroid gland were performed before and after 131-I therapy (6-8 months). The examination was performed in thyroid division of NINMAS by advanced ultrasound machine with a linear transducer (5-12 MHz). The patients were divided into two groups. Group A-diffuse toxic goiter prior to radioiodine therapy and group B- same patients 6-8 months after radioiodine therapy.Results: A reduction in the anterior –posterior diameter of the thyroid gland was observed from pre to post treatment evaluation, performed at 6 and or 8 months after radioiodine therapy. Color Doppler showed increased parenchymal vascularity at the time of diagnosis which gradually declined after radioiodine therapy. Thyroid blood flow, as assessed by PSV of ITA, was significantly higher in Group A than in Group B respectively (70.5 ± 15.5 cm/ sec versus 22.2 ± 12.9 cm/sec). PSV was measured in 10 healthy euthyroid adults & their PSV ranged 13-20 cm/Sec. Parenchymal vascularity of the thyroid gland was higher in hyperthyroid patients than in euthyroid patients.Conclusion: Assessment of thyroid gland by B-mode ultrasound and blood flow by color Doppler study (CDS) is an effective marker in the initial diagnosis of diffuse toxic goiter.Bangladesh J. Nuclear Med. 20(1): 41-44, January 2017

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Low incidence of focal lesions in the thyroid gland in patients with hereditary hemochromatosis — a single center study from Poland

Endokrynologia Polska ◽

10.5603/ep.a2021.0008 ◽

2021 ◽

Author(s):

Katarzyna Joanna Banaszkiewicz ◽

Katarzyna Sikorska ◽

Damian Panas ◽

Łukasz Obołończyk ◽

Krzysztof Sworczak

Keyword(s):

Thyroid Gland ◽

Hereditary Hemochromatosis ◽

Single Center ◽

Focal Lesions ◽

Single Center Study ◽

Low Incidence ◽

Center Study

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Ultrasonography Duplex - Color Doppler of Thyroid Gland in Patients With Serious Diseases Before and After Radioiodine (131-I)

Ultrasound in Medicine & Biology ◽

10.1016/j.ultrasmedbio.2013.02.339 ◽

2013 ◽

Vol 39 (5) ◽

pp. S72

Author(s):

T. Adler ◽

M.T.P. Souza ◽

M.C. Chammas ◽

G.G. Cerri

Keyword(s):

Thyroid Gland ◽

Color Doppler ◽

Before And After

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Integrated ultrasound investigation and magnetic resonance tomography in the diagnosis of focal thyroid pathology

Kazan medical journal ◽

10.17816/kmj1873 ◽

2012 ◽

Vol 93 (3) ◽

pp. 484-487 ◽

Cited By ~ 1

Author(s):

L A Timofeeva

Keyword(s):

Magnetic Resonance ◽

Thyroid Gland ◽

Diagnostic Accuracy ◽

Ultrasound Examination ◽

Magnetic Resonance Tomography ◽

Primary Diagnosis ◽

Thyroid Diseases ◽

Focal Lesions ◽

Thyroid Pathology ◽

Ultrasound Investigation

Aim. To determine the features an integrated ultrasound investigation and magnetic resonance tomography in the diagnosis of focal thyroid pathology. Methods. Integrated ultrasound examination was conducted in 1440 patients with focal lesions of the thyroid gland at the age of 17-76 years, and magnetic resonance tomography was performed in 91 patients (65 females and 26 males). Results. It was established that the informativeness of the ultrasound investigation is characterized by the following parameters: sensitivity - 92.1%, specificity - 78.6%, and diagnostic accuracy - 90.3%; the informativeness of magnetic resonance tomography: sensitivity - 94.1%, specificity - 89.6 %, and diagnostic accuracy - 91.0%. Conclusion. Integrated use of ultrasound investigation and magnetic resonance tomography significantly increases the informativeness during primary diagnosis of focal thyroid diseases.

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