Fear of cancer recurrence in bladder cancer patients undergoing radical cystectomy with urinary diversion - Preliminary results from a prospective study (NCT04535921)

AbstractObjectivesPsychosocial interventions that mitigate psychosocial distress in cancer patients are important. The primary aim of this study was to examine the feasibility and acceptability of an adaptation of the Mindful Self-Compassion (MSC) program among adult cancer patients. A secondary aim was to examine pre–post-program changes in psychosocial wellbeing.MethodThe research design was a feasibility and acceptability study, with an examination of pre- to post-intervention changes in psychosocial measures. A study information pack was posted to 173 adult cancer patients 6 months–5 years post-diagnosis, with an invitation to attend an eight-week group-based adaptation of the MSC program.ResultsThirty-two (19%) consented to the program, with 30 commencing. Twenty-seven completed the program (mean age: 62.93 years, SD 14.04; 17 [63%] female), attending a mean 6.93 (SD 1.11) group sessions. There were no significant differences in medico-demographic factors between program-completers and those who did not consent. However, there was a trend toward shorter time since diagnosis in the program-completers group. Program-completers rated the program highly regarding content, relevance to the concerns of cancer patients, and the likelihood of recommending the program to other cancer patients. Sixty-three percent perceived that their mental wellbeing had improved from pre- to post-program; none perceived a deterioration in mental wellbeing. Small-to-medium effects were observed for depressive symptoms, fear of cancer recurrence, stress, loneliness, body image satisfaction, mindfulness, and self-compassion.Significance of resultsThe MSC program appears feasible and acceptable to adults diagnosed with non-advanced cancer. The preliminary estimates of effect sizes in this sample suggest that participation in the program was associated with improvements in psychosocial wellbeing. Collectively, these findings suggest that there may be value in conducting an adequately powered randomized controlled trial to determine the efficacy of the MSC program in enhancing the psychosocial wellbeing of cancer patients.

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1715 CELL CYCLE REGULATORY PROTEIN ALTERATIONS IN A PROSPECTIVE STUDY OF PATIENTS WITH ORGAN-CONFINED BLADDER CANCER FOLLOWING RADICAL CYSTECTOMY

The Journal of Urology ◽

10.1016/j.juro.2010.02.1562 ◽

2010 ◽

Vol 183 (4S) ◽

Cited By ~ 1

Author(s):

Seth P. Lerner ◽

Walter Stadler ◽

Susan Groshen ◽

Jie Cai ◽

Anirban P. Mitra ◽

...

Keyword(s):

Cell Cycle ◽

Bladder Cancer ◽

Prospective Study ◽

Radical Cystectomy ◽

Regulatory Protein ◽

Cell Cycle Regulatory Protein ◽

A Prospective Study ◽

Protein Alterations

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Perioperative Outcomes of Different Surgical Methods Among Bladder Cancer Patients Undergoing Radical Cystectomy With Neobladder Urinary Diversion

The Korean Journal of Urological Oncology ◽

10.22465/kjuo.2021.19.4.261 ◽

2021 ◽

Vol 19 (4) ◽

pp. 261-270

Author(s):

Hak Ju Kim ◽

Changhee Ye ◽

Jin Hyuck Kim ◽

Hwanik Kim ◽

Sangchul Lee ◽

...

Keyword(s):

Bladder Cancer ◽

Cancer Patients ◽

Radical Cystectomy ◽

Urinary Diversion ◽

Major Complication ◽

Perioperative Outcomes ◽

Transfusion Rate ◽

Major Complications ◽

Surgical Methods ◽

Significant Factors

Purpose: To compare perioperative outcomes according to surgical methods among bladder cancer patients who underwent radical cystectomy (RC) with neobladder urinary diversion.Materials and Methods: Between June 2007 and January 2020, 89 bladder cancer patients who received RC with neobladder urinary diversion were enrolled in this study. Patients were stratified into surgical methods – (1) open RC with neobladder (ONB) reconstruction, (2) robotassisted RC (RARC) with extracorporeal neobladder (ECNB) reconstruction, and (3) RARC with intracorporeal neobladder (ICNB) reconstruction. Perioperative outcomes were compared among the 3 groups, with major complications defined according to Clavien-Dindo grades III–V within 90 days. Logistic regression analysis was performed to identify significant factors for postoperative complications.Results: Of 89 patients, 28 (31%) had ONB, 31 (35%) had ECNB, and 30 (34%) had ICNB. The median operative time was 471 minutes, and the ICNB group (424.5 minutes) was significantly less than ONB (444.5 minutes) and ECNB groups (542.9 minutes) (p=0.001). Transfusion rate was also significantly less in the ICNB group (13%) (p=0.001). Complications were recorded in 67 patients (75%) and major complications in 22 of all patients (25%). The major complication rate was significantly less in ICNB (13.4%) than in ONB (25%) and ECNB (35%) (p=0.003). Multivariate analysis showed surgical methods (ICNB) (odds ratio [OR], 0.709; p=0.003) and age (OR, 1.150; p=0.001) were significant factors related to occurrence of major postoperative complications.Conclusions: RARC with ICNB reduces postoperative complications compared to ONB and ECNB.

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