Arrested testis development in the cpk mouse may be the result of abnormal steroid metabolism

SummaryEnovid (5 mg norethynodrel and 0.075 mg ethynylestradiol-3-methyl ether) therapy in young normal human subjects causes an increase in plasma fibrinogen of 32.4% (P >C 0.001). Consideration of this effect together with other effects of Enovid on the activity of specific blood coagulatory factors suggests that the steroids are exerting their effect at a specific site of the blood coagulation and/or fibrinolytic system. The broad spectrum of changes which are induced by the steroids may be attributed to a combination of a chain reaction and feed-back control.

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STUDIES OF STEROID METABOLISM IN MAN

Acta Endocrinologica ◽

10.1530/acta.0.xxxivs093 ◽

1960 ◽

Vol 34 (2_Suppla) ◽

pp. S93-S97 ◽

Cited By ~ 2

Author(s):

T. F. Gallagher

Keyword(s):

Steroid Metabolism

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Melatonin: A Rediscovered Antitumor Hormone? Its Relation to Surface Receptors; Sex Steroid Metabolism, Immunologic Response, and Chronobiologic Factors in Tumor Growth and Therapy

Cancer Investigation ◽

10.3109/07357908709170112 ◽

1987 ◽

Vol 5 (4) ◽

pp. 379-385 ◽

Cited By ~ 9

Author(s):

W. Regelson ◽

W. Pierpaoli

Keyword(s):

Tumor Growth ◽

Steroid Metabolism ◽

Sex Steroid ◽

Immunologic Response ◽

Surface Receptors

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Steroid metabolism

Reactome - a curated knowledgebase of biological pathways ◽

10.3180/react_9429.2 ◽

2007 ◽

Vol 21 ◽

Author(s):

B Jassal

Keyword(s):

Steroid Metabolism

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Steroid Metabolism as a Mechanism of Escape from Progesterone-mediated Growth Inhibition in Trichophyton mentagrophytes

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)60447-8 ◽

1989 ◽

Vol 264 (19) ◽

pp. 11186-11192

Author(s):

K V Clemons ◽

E P Stover ◽

G Schär ◽

P A Stathis ◽

K Chan ◽

...

Keyword(s):

Growth Inhibition ◽

Trichophyton Mentagrophytes ◽

Steroid Metabolism

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Studies in Steroid Metabolism

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)64170-5 ◽

1961 ◽

Vol 236 (5) ◽

pp. 1312-1317

Author(s):

Herbert H. Wotiz ◽

Horace F. Martin

Keyword(s):

Steroid Metabolism

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Development of Testis Cords and the Formation of Efferent Ducts in Xenopus laevis: Differences and Similarities with Other Vertebrates

Sexual Development ◽

10.1159/000513416 ◽

2021 ◽

pp. 1-14

Author(s):

Yuanyuan Li ◽

Jinbo Li ◽

Man Cai ◽

Zhanfen Qin

Keyword(s):

Cell Proliferation ◽

Xenopus Laevis ◽

Germ Cells ◽

Sertoli Cells ◽

Testis Development ◽

Larval Stages ◽

Efferent Ducts ◽

Steroidogenic Cells ◽

Testis Cord ◽

Anterior Posterior

The knowledge of testis development in amphibians relative to amniotes remains limited. Here, we used Xenopus laevis to investigate the process of testis cord development. Morphological observations revealed the presence of segmental gonomeres consisting of medullary knots in male gonads at stages 52–53, with no distinct gonomeres in female gonads. Further observations showed that cell proliferation occurs at specific sites along the anterior-posterior axis of the future testis at stage 50, which contributes to the formation of medullary knots. At stage 53, adjacent gonomeres become close to each other, resulting in fusion; then (pre-)Sertoli cells aggregate and form primitive testis cords, which ultimately become testis cords when germ cells are present inside. The process of testis cord formation in X. laevis appears to be more complex than in amniotes. Strikingly, steroidogenic cells appear earlier than (pre-)Sertoli cells in differentiating testes of X. laevis, which differs from earlier differentiation of (pre-)Sertoli cells in amniotes. Importantly, we found that the mesonephros is connected to the testis gonomere at a specific site at early larval stages and that these connections become efferent ducts after metamorphosis, which challenges the previous concept that the mesonephric side and the gonadal side initially develop in isolation and then connect to each other in amphibians and amniotes.

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