Stromal cell-derived factor 1 is secreted by meningeal cells and acts as chemotactic factor on neuronal stem cells of the cerebellar external granular layer

Neuroscience ◽  
2002 ◽  
Vol 115 (1) ◽  
pp. 295-305 ◽  
Author(s):  
K Reiss ◽  
R Mentlein ◽  
J Sievers ◽  
D Hartmann
Keyword(s):  
Stem Cells ◽  
Stromal Cell ◽  
Granular Layer ◽  
Chemotactic Factor ◽  
External Granular Layer ◽  
Neuronal Stem Cells ◽  
Meningeal Cells ◽  
Stromal Cell Derived Factor

scholarly journals Stromal cell-derived factor 1/CXCR4 signaling is critical for the recruitment of mesenchymal stem cells to the fracture site during skeletal repair in a mouse model

2009 ◽  
Vol 60 (3) ◽  
pp. 813-823 ◽  
Author(s):  
Toshiyuki Kitaori ◽  
Hiromu Ito ◽  
Edward M. Schwarz ◽  
Ryosuke Tsutsumi ◽  
Hiroyuki Yoshitomi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Mouse Model ◽  
Stromal Cell ◽  
Fracture Site ◽  
Cxcr4 Signaling ◽  
Stromal Cell Derived Factor

scholarly journals Mesenchymal Stem Cells with Increased Stromal Cell-Derived Factor 1 Expression Enhanced Fracture Healing

2015 ◽  
Vol 21 (3-4) ◽  
pp. 594-602 ◽  
Author(s):  
Chih-Yuan Ho ◽  
Anita Sanghani ◽  
Jia Hua ◽  
Melanie Coathup ◽  
Priya Kalia ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Fracture Healing ◽  
Stromal Cell ◽  
Stromal Cell Derived Factor

scholarly journals cMyb regulates hematopoietic stem/progenitor cell mobilization during zebrafish hematopoiesis

Blood ◽  
2011 ◽  
Vol 118 (15) ◽  
pp. 4093-4101 ◽  
Author(s):  
Yiyue Zhang ◽  
Hao Jin ◽  
Li Li ◽  
F. Xiao-Feng Qin ◽  
Zilong Wen
Keyword(s):  
Stem Cells ◽  
Progenitor Cell ◽  
Stromal Cell ◽  
Cell Tracking ◽  
Time Lapse ◽  
Hematopoietic Stem ◽  
Hematopoietic Organs ◽  
Stromal Cell Derived Factor ◽  
Cell Mobilization ◽  
Ventral Wall

Abstract The establishment of the HSC pool in vertebrates depends not only on the formation and the propagation of these stem cells but also on their proper trafficking among the defined hematopoietic organs. However, the physiologic mechanisms that regulate HSC mobilization remain elusive. Through analysis of the zebrafish cmyb mutant cmybhkz3, we show that the suppression of cMyb function abrogates larval and adult hematopoiesis, with concomitant accumulation of hematopoietic stem/progenitor cells (HSPCs) in their birthplace, the ventral wall of the dorsal aorta (VDA). Cell tracking and time-lapse recording reveal that the accumulation of HSPCs in cmybhkz3 mutants is caused by the impairment of HSPC egression from the VDA. Further analysis demonstrates that the HSPC migratory defects in cmybhkz3 mutants are at least partly because of adversely elevated levels of chemokine stromal cell-derived factor 1a (Sdf1a). Our study reveals that cMyb plays a hitherto unidentified role in dictating physiologic HSPC migration by modulating Sdf1a signaling.

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