Long-term regional control after radiation therapy and neck dissection for base of tongue carcinoma

PURPOSE: To evaluate irradiation alone for treatment of base-of-tongue cancer. PATIENTS AND METHODS: Two hundred seventeen patients with squamous cell carcinoma of the base of tongue were treated with radiation alone and had follow-up for ≥ 2 years. RESULTS: Local control rates at 5 years were as follows: T1, 96%; T2, 91%; T3, 81%; and T4, 38%. Multivariate analysis revealed that T stage (P = .0001) and overall treatment time (P = .0006) significantly influenced local control. The 5-year rates of local-regional control were as follows: I, 100%; II, 100%; III, 83%; IVA, 64%; and IVB, 65%. Multivariate analysis revealed that the following parameters significantly affect the probability of this end point: T stage (P = .0001), overall treatment time (P = .0001), overall stage (P = .0131), and addition of a neck dissection (P = .0021). The rates of absolute and cause-specific survival at 5 years were as follows: I, 50% and 100%; II, 81% and 100%; III, 65% and 76%; IVA, 42% and 56%; and IVB, 44% and 52%. Severe radiation complications developed in eight patients (4%). CONCLUSION: The likelihood of cure after external-beam irradiation was related to stage, overall treatment time, and addition of a planned neck dissection. The local-regional control rates and survival rates after radiation therapy were comparable to those after surgery, and the morbidity associated with irradiation was less.

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Long term results of primary radiotherapy with/without neck dissection for squamous cell cancer of the base of tongue

Head & Neck ◽

10.1002/(sici)1097-0347(199812)20:8<668::aid-hed2>3.0.co;2-9 ◽

1998 ◽

Vol 20 (8) ◽

pp. 668-673 ◽

Cited By ~ 85

Author(s):

Louis B. Harrison ◽

Henry J. Lee ◽

David G. Pfister ◽

Dennis H. Kraus ◽

Carol White ◽

...

Keyword(s):

Neck Dissection ◽

Squamous Cell ◽

Squamous Cell Cancer ◽

Cell Cancer ◽

Long Term Results ◽

Base Of Tongue ◽

Primary Radiotherapy

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Management of parotid metastases from cutaneous melanoma of the head and neck

The Journal of Laryngology & Otology ◽

10.1017/s002221510011268x ◽

1990 ◽

Vol 104 (4) ◽

pp. 350-351 ◽

Cited By ~ 9

Author(s):

A. B. S. Ball ◽

J. Meirion Thomas

Keyword(s):

Neck Dissection ◽

Cutaneous Melanoma ◽

Radical Neck Dissection ◽

Cutaneous Malignant Melanoma ◽

Elective Neck Dissection ◽

Superficial Parotidectomy ◽

Regional Control ◽

Node Metastases ◽

Long Term Prognosis

AbstractParotid metastases from a cutaneous malignant melanoma are uncommon. Although the long-term prognosis is poor, loco-regional palliation is important. In a group of eight patients with parotid metastases, local control was obtained by superficial parotidectomy. Occult cervical lymph node metastases were identified in five cases in whom radical neck dissection provided regional control. Superficial parotidectomy with elective neck dissection is advocated for patients with parotid metastases from cutaneous melanoma to ensure optimal loco-regional palliation.

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