Role of nitric oxide in ethanol-induced ascorbic acid release in striatum of freely moving mice

2003 ◽  
Vol 145 (1) ◽  
pp. 69-78 ◽  
Author(s):  
P Yan
2000 ◽  
Vol 131 (4) ◽  
pp. 836-842 ◽  
Author(s):  
Pier Andrea Serra ◽  
Giovanni Esposito ◽  
M Rosaria Delogu ◽  
Rossana Migheli ◽  
Gaia Rocchitta ◽  
...  

2006 ◽  
Vol 2 ◽  
pp. S524-S524
Author(s):  
Joanna B. Strosznajder ◽  
Joanna Glowacka ◽  
Alicja Zabielna ◽  
Malgorzata Chalimoniuk

2007 ◽  
Vol 292 (3) ◽  
pp. R1158-R1164 ◽  
Author(s):  
Hong Zheng ◽  
Keshore R. Bidasee ◽  
William G. Mayhan ◽  
Kaushik P. Patel

Erectile dysfunction is a serious and common complication of diabetes mellitus. The proposed mechanisms for erectile dysfunction in diabetes include central and autonomic neuropathy, endothelial dysfunction, and smooth muscle dysfunction. The paraventricular nucleus (PVN) of the hypothalamus is known to be involved in centrally mediated penile erection. This study was designed to examine the role of nitric oxide (NO) within the central nervous system component of the behavioral responses including erection in diabetic rats. N-methyl-d-aspartic acid (NMDA)-induced erection, yawning, and stretch through the PVN can be blocked by prior administration of NO synthase (NOS) blocker, l-NMMA, in freely moving, conscious male normal rats. Four weeks after streptozotocin (STZ) and vehicle injections, NMDA-induced erection, yawning, and stretch responses through the PVN are significantly blunted in diabetic rats compared with control rats. Examination of neuronal NOS (nNOS) protein by Western blot analysis indicated a reduced amount of nNOS protein in the PVN of rats with diabetes compared with control rats. Furthermore, restoring nNOS within the PVN by gene transfer using adenoviral transfection significantly restored the erectile and yawning responses to NMDA in diabetic rats. These data demonstrate that a blunted NO mechanism within the PVN may contribute to NMDA-induced erectile dysfunction observed in diabetes mellitus.


1997 ◽  
Vol 745 (1-2) ◽  
pp. 173-182 ◽  
Author(s):  
Paolo Enrico ◽  
Giovanni Esposito ◽  
Maria A. Mura ◽  
Luigia Fresu ◽  
Guglielmo De Natale ◽  
...  

2001 ◽  
Vol 134 (2) ◽  
pp. 275-282 ◽  
Author(s):  
Pier Andrea Serra ◽  
Gaia Rocchitta ◽  
Giovanni Esposito ◽  
M Rosaria Delogu ◽  
Rossana Migheli ◽  
...  

1996 ◽  
Vol 301 (1-3) ◽  
pp. 179-188 ◽  
Author(s):  
Seitaro Ohkuma ◽  
Masashi Katsura ◽  
Jin-Long Guo ◽  
Hidehiko Narihara ◽  
Takeshi Hasegawa ◽  
...  

2001 ◽  
Vol 132 (4) ◽  
pp. 941-949 ◽  
Author(s):  
Pier Andrea Serra ◽  
Giovanni Esposito ◽  
M Rosaria Delogu ◽  
Rossana Migheli ◽  
Gaia Rocchitta ◽  
...  

2000 ◽  
Vol 129 (3) ◽  
pp. 582-588 ◽  
Author(s):  
Maddalena Miele ◽  
Maria A Mura ◽  
Paolo Enrico ◽  
Giovanni Esposito ◽  
Pier A Serra ◽  
...  

1998 ◽  
Vol 797 (1) ◽  
pp. 94-102 ◽  
Author(s):  
Paolo Enrico ◽  
Maria A Mura ◽  
Giovanni Esposito ◽  
Pierandrea Serra ◽  
Rossana Migheli ◽  
...  

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