scholarly journals Serum levels of unbound free fatty acids reveal high sensitivity for early detection of acute myocardial infarction in patient samples from the TIMI II trial

2002 ◽  
Vol 39 ◽  
pp. 312 ◽  
Author(s):  
Alan M. Kleinfeld ◽  
Kevin J. Kleinfeld ◽  
Jesse E. Adams
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Fatty Acids ◽  
Early Detection ◽  
Free Fatty Acids ◽  
High Sensitivity ◽  
Serum Levels ◽  
Unbound Free Fatty Acids

scholarly journals Changes of Ionized Magnesium and Free Fatty Acids in Serum after Acute Myocardial Infarction

1995 ◽  
Vol 33 (9) ◽  
Author(s):  
Frank Bertschat ◽  
Hartmut Ising ◽  
Theodor Günther ◽  
Allen Jeremias ◽  
Elisabeth Jeremias
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Fatty Acids ◽  
Free Fatty Acids ◽  
Ionized Magnesium

Small Doses of Subcutaneous Heparin, Plasma Free-Fatty-Acids, and the Incidence of Ventricular Arrhythmias in Patients with Acute Myocardial Infarction

1979 ◽  
Author(s):  
H. Arnesen ◽  
Ø. Skjæggestad ◽  
N. Wik
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Fatty Acids ◽  
Free Fatty Acids ◽  
Ventricular Arrhythmias ◽  
Prospective Trial ◽  
Plasma Free Fatty Acids ◽  
Vein Thrombosis ◽  
Subcutaneous Heparin ◽  
Small Doses

The frequency of deep vein thrombosis (DVT) diagnosed with the 125I-fibrinogen technique in patients with acute myocardial infarction (AMI) has been found to be reduced frcm about 20% without anticoagulation to about 5% with warfarin or small doses of subcutaneous heparin.A somewhat higher incidence of ventricular tachycardia in patients with AMI treated with small doses of subcutaneous heparin has been reported. A possible mechanism might be heparin-induced activation of lipoprotein lipase with consequent increase of plasma free-fatty-acids (FFA), which have been found to be arrhythmogenic in patients with AMI.In the present prospective trial, 99 patients with AMI and a history of less than 12 hours were allocated at random to treatment with subcutaneous heparin 5000 IU twice daily, or warfarin. In a randomized subsample of 21 patients fasting FFA analyses were performed before and 2 hours after the administration of anticoagulants on day 1 and 2.No measurable increase in FFA concentrations was demonstrated in the heparin-treated patients, in spite of a significant influence on the thrombin clotting time.The frequency of ventricular arrhythmias as detected by continous tape recordings was equal in the two treatment groups.It is concluded that subcutaneous heparin 5 000 IU every 12 hours seems to be a safe measures of prophylaxis against venous thromboembolic ccmplications in patients with AMI.

scholarly journals The Association Between S100A8/A9 and the Development of Very Late Stent Thrombosis in Patients With Acute Myocardial Infarction

2020 ◽  
Vol 26 ◽  
pp. 107602962094329
Author(s):  
Xiang Wang ◽  
Meng Guan ◽  
Xiuhang Zhang ◽  
Taiyuan Ma ◽  
Muli Wu ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Stent Thrombosis ◽  
High Sensitivity ◽  
Coronary Intervention ◽  
Serum Levels ◽  
Late Stent Thrombosis ◽  
Very Late Stent Thrombosis ◽  
Hs Crp

Very late stent thrombosis (VLST) is a rare but serious complication following percutaneous coronary intervention (PCI). S100A8/A9 plays an important role in thrombosis through modulating the inflammatory response. This observational study aimed to reveal the association between S100A8/A9 and VLST. Continuous blood samples were collected from patients at both the time of index PCI for acute myocardial infarction (AMI) and the time of PCI for VLST (VLST group) or follow-up coronary angiography (AMI group). In all, 56 patients were selected in each group from a cohort of 8476 patients and other 112 individuals who underwent health checkups (normal control [NC] group) were selected as controls. Serum levels of S100A8/A9 and high sensitivity C-reactive protein (hs-CRP) were tested and compared. The mean level of S100A8/A9 was 3754.4 ± 1688.9 ng/mL during index PCI and increased to 5517.8 ± 2650.9 ng/mL at the time of VLST; in the AMI group, S100A8/A9 level was 2434.9 ± 1243.4 ng/mL during index PCI and decreased to 1568.2 ± 772.1 ng/mL during follow-up, similar to that detected in the NC group (1618.2 ± 641.4 ng/mL). Of note, S100A8/A9 levels showed significant increases during VLST when compared to its own levels during index PCI, which was different from the changes of hs-CRP. Higher serum levels of S100A8/A9 are associated with the development of VLST.

Turnover of Plasma Glucose and Free Fatty Acids in Patients on the First Day after Myocardial Infarction

1976 ◽  
Vol 50 (5) ◽  
pp. 401-407
Author(s):  
I. A. Nimmo ◽  
R. H. Smith ◽  
M. A. Dolder ◽  
M. F. Oliver
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Fatty Acids ◽  
Free Fatty Acids ◽  
Myocardial Ischaemia ◽  
Plasma Glucose ◽  
Glucose Concentration ◽  
Plasma Concentrations ◽  
Acute Episode ◽  
Glucose Turnover

1. The turnover of plasma glucose and free fatty acids was measured in ten patients within 24 h of the onset of symptoms of acute myocardial infarction and in two with symptoms of acute myocardial ischaemia. The measurements were repeated in seven of the patients 12–40 weeks after the acute episode. 2. Both for the patients with acute myocardial infarction alone and for all the individuals studied the turnover of glucose increased with plasma glucose concentration but was not related to the turnover of free fatty acids or the plasma concentrations of free fatty acids, insulin or total catecholamines. There was no obvious difference in the nature of the glucose turnover—concentration relationship between the patients with acute myocardial infarction, with acute myocardial ischaemia and on re-examination. 3. For all the individuals studied the turnover of free fatty acids increased with the concentration of these but was not related to the turnover of glucose or the plasma concentrations of glucose, insulin or total catecholamines. There was no obvious difference in the nature of the free fatty acids turnover—concentration relationship between the patients with acute myocardial infarction, with acute myocardial ischaemia and on re-examination.

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