scholarly journals CHANGES IN THIGH MUSCLE VOLUME OVER A ONE YEAR PERIOD IN PATIENTS WITH PERIPHERAL ARTERIAL DISEASE (PAD): A MAGNETIC RESONANCE IMAGING (MRI) ANALYSIS FROM THE EFFECT OF LIPID MODIFICATION ON PERIPHERAL ARTERIAL DISEASE AFTER ENDOVASCULAR INTERVENTION TRIAL (ELIMIT)

2010 ◽  
Vol 55 (10) ◽  
pp. A156.E1457
Author(s):  
Gerd Brunner ◽  
Joel D. Morrisett ◽  
Eric Yang ◽  
Anirudh Kumar ◽  
Salim S. Virani ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
Thigh Muscle ◽  
Lipid Modification ◽  
Intervention Trial ◽  
Resonance Imaging ◽  
Magnetic Resonance Imaging Mri ◽  
One Year ◽  
Peripheral Arterial

Guiding peripheral arterial disease management with magnetic resonance imaging

VASA ◽  
2019 ◽  
Vol 48 (3) ◽  
pp. 217-222
Author(s):  
Edwin A. Takahashi ◽  
Kristin A. Kinsman ◽  
Newton B. Neidert ◽  
Phillip M. Young
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
Resonance Imaging ◽  
Vessel Patency ◽  
Magnetic Resonance Imaging Mri ◽  
Peripheral Arterial ◽  
Important Test

Abstract. Peripheral arterial disease (PAD) management is exceptionally challenging. Despite advances in diagnostic and therapeutic technologies, long-term vessel patency and limb salvage rates are limited. Patients with PAD frequently require extensive workup with noninvasive tests and imaging to delineate their disease and help guide appropriate management. Ultrasound and computed tomography are commonly ordered in the workup of PAD. Magnetic resonance imaging (MRI), on the other hand, is less often acknowledged as a useful tool in this disease. Nevertheless, MRI is an important test that can effectively characterize atherosclerotic plaque, assess vessel patency in highly calcified disease, and measure lower extremity perfusion.

scholarly journals Calf muscle perfusion as measured with magnetic resonance imaging to assess peripheral arterial disease

2016 ◽  
Vol 54 (11) ◽  
pp. 1667-1681 ◽  
Author(s):  
Gerd Brunner ◽  
Jean Bismuth ◽  
Vijay Nambi ◽  
Christie M. Ballantyne ◽  
Addison A. Taylor ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
Calf Muscle ◽  
Resonance Imaging ◽  
Muscle Perfusion ◽  
Peripheral Arterial

Abstract 18: The Effect of Lipid Modification on Peripheral Arterial Disease after Endovascular Intervention Trial (ELIMIT)

2013 ◽  
Vol 33 (suppl_1) ◽  
Author(s):  
Gerd Brunner ◽  
Eric Y Yang ◽  
Anirudh Kumar ◽  
Sun Wensheng ◽  
Salim S Salim ◽  
...  
Keyword(s):  
Peripheral Arterial Disease ◽  
Triple Therapy ◽  
Extended Release ◽  
Arterial Disease ◽  
Endovascular Intervention ◽  
Proton Density ◽  
Lipid Modification ◽  
Intervention Trial ◽  
Significant Difference ◽  
Peripheral Arterial

BACKGROUND The Effect of Lipid Modification on Peripheral Arterial Disease after Endovascular Intervention Trial (ELIMIT), a prospective double-blind randomized study, was designed to determine over 24-months, the effects of triple drug lipid modification therapy versus mono therapy on the progression of atherosclerotic lesions in the distal superficial femoral artery (SFA), as assessed by 3.0T magnetic resonance imaging (MRI). METHODS A total of 95 patients were randomized to either mono therapy with simvastatin (40mg) or triple therapy with simvastatin (40mg), extended-release niacin (1.5g), and ezetimibe (10mg). MR imaging was performed at baseline, 6-, 12-, and 24-months. SFA wall, lumen, and total vessel volumes were quantified using inter-visit co-registered proton-density-weighted turbo spin echo MRI sequences. MRI derived SFA parameters and lipids were analyzed with multi-level models and non-parametric tests, respectively. RESULTS Baseline characteristics did not differ between mono and triple therapy groups, except for ethnicity (Table). There was no difference in adverse cardiovascular events between groups (p=0.99). SFA wall, lumen, and vessel volumes increased non-significantly for both groups between baseline and 24-months. Non-high-density lipoprotein cholesterol showed a larger reduction in triple therapy compared with mono therapy at 12-months (p=0.01). CONCLUSION Despite improved atherogenic lipid profiles, there was no significant difference between mono therapy with simvastatin and triple therapy with simvastatin, extended-release niacin, and ezetimibe for the 24-month changes in total SFA wall, lumen, and vessel volumes.

scholarly journals Magnetic resonance imaging-based computational modelling of blood flow and nanomedicine deposition in patients with peripheral arterial disease

2015 ◽  
Vol 12 (106) ◽  
pp. 20150001 ◽  
Author(s):  
Shaolie S. Hossain ◽  
Yongjie Zhang ◽  
Xiaoyi Fu ◽  
Gerd Brunner ◽  
Jaykrishna Singh ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Blood Flow ◽  
Magnetic Resonance ◽  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
Local Geometry ◽  
Resonance Imaging ◽  
Post Intervention ◽  
Vascular Geometry ◽  
Peripheral Arterial

Peripheral arterial disease (PAD) is generally attributed to the progressive vascular accumulation of lipoproteins and circulating monocytes in the vessel walls leading to the formation of atherosclerotic plaques. This is known to be regulated by the local vascular geometry, haemodynamics and biophysical conditions. Here, an isogeometric analysis framework is proposed to analyse the blood flow and vascular deposition of circulating nanoparticles (NPs) into the superficial femoral artery (SFA) of a PAD patient. The local geometry of the blood vessel and the haemodynamic conditions are derived from magnetic resonance imaging (MRI), performed at baseline and at 24 months post intervention. A dramatic improvement in blood flow dynamics is observed post intervention. A 500% increase in peak flow rate is measured in vivo as a consequence of luminal enlargement. Furthermore, blood flow simulations reveal a 32% drop in the mean oscillatory shear index, indicating reduced disturbed flow post intervention. The same patient information (vascular geometry and blood flow) is used to predict in silico in a simulation of the vascular deposition of systemically injected nanomedicines. NPs, targeted to inflammatory vascular molecules including VCAM-1, E-selectin and ICAM-1, are predicted to preferentially accumulate near the stenosis in the baseline configuration, with VCAM-1 providing the highest accumulation (approx. 1.33 and 1.50 times higher concentration than that of ICAM-1 and E-selectin, respectively). Such selective deposition of NPs within the stenosis could be effectively used for the detection and treatment of plaques forming in the SFA. The presented MRI-based computational protocol can be used to analyse data from clinical trials to explore possible correlations between haemodynamics and disease progression in PAD patients, and potentially predict disease occurrence as well as the outcome of an intervention.

scholarly journals Simultaneous bilateral magnetic resonance imaging of the femoral arteries in peripheral arterial disease patients

2011 ◽  
Vol 34 (1) ◽  
pp. 150-156 ◽  
Author(s):  
Ryan Brown ◽  
Christof Karmonik ◽  
Gerd Brunner ◽  
Alan Lumsden ◽  
Christie Ballantyne ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
Resonance Imaging ◽  
Femoral Arteries ◽  
Peripheral Arterial
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