scholarly journals PREVALENCE OF PULMONARY HYPERTENSION IN PATIENTS WITH END STAGE RENAL DISEASE AND ACUTE EFFECT OF HEMODIALYSIS ON RIGHT VENTRICULAR HEMODYNAMICS AND FUNCTION - PRELIMINARY ECHOCARDIOGRAPHIC FINDINGS FROM THE PROSPECTIVE PEPPER- STUDY

2011 ◽  
Vol 57 (14) ◽  
pp. E853
Author(s):  
Christoph Hammerstingl ◽  
Stefan Pabst ◽  
Diana Momcilovic ◽  
Felix Hundt ◽  
Rainer Woitas ◽  
...  
Author(s):  
Rakesh Bahadur Adhikari

Introduction: Chronic hemodialysis (HD) ends up with right ventricular (RV) dysfunction and increased pulmonary hypertension (PHTN). Left to right shunt in dialysis patients due to arterio-venous fistula (AVF) causes chronic volume overload, independent of rise in body water leading to worsening RV overload and RV dysfunction (RVD). Aims & Objectives: To determine the prevalence of RV dysfunction & pulmonary hypertension and its relationship to the number of dialysis sessions in patients of ESRD. Place and duration of study: Department of Cardiology & Nephrology, Sheikh Zayed Hospital, Lahore for one year from March 2016 - March 2017. Material & Methods: This cross-sectional analytical hospital based study enrolled 145 Patients of End-Stage Renal Disease (ESRD) on regular 4-hours HD sessions at two or more times per week for at least 3 months. Echocardiography (Echo) with 2-D, M (Motion) Mode & Doppler studies were done. RV dysfunction by TAPSE value less than 15mm & PHTN by Systolic pulmonary artery pressure >35 mm Hg or tricuspid regurgitation velocity (VTR) ?2m/s at rest were noted. Data was analyzed on SPSS version 20. Results: RV dysfunction was seen in 40.7% (59) of patients and the frequency rose across the 4 dialysis session groups (13.8%, 37.3%, 51.7% & 100%, p<0.001). PHTN was observed in 44.1% of the patients and the prevalence progressively increased across the groups (17.2%, 45.1%, 53.3% & 80.01%, p<0.003). There was significant association between RVD and PHTN (p=0.011). Conclusion: We observed positive correlation between RV dysfunction and PHTN with total number of hemodialysis sessions. Early detection of sub-clinical RV dysfunction may improve mortality and morbidity by optimizing treatment options.


2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Irfan Mirza ◽  
Ahmad Zeb Khan ◽  
Mufti Baleegh ◽  
Amirullah . ◽  
Tahir Rashid ◽  
...  

Background: Chronic kidney disease is one of the global public health problem. It is a major cause of mortality and morbidity. Endstage renal disease patients will have either option of renal transplant or dialysis. Although dialysis is an effective form of renalreplacement therapy but it also have long term side effects. Pulmonary hypertension is one of them.Objective: To find frequency of pulmonary hypertension among end stage renal disease patients on hemodialysis in our populationMaterial and Methods: In this study a total of 163 patients were included, using 18.8% prevalence of pulmonary hypertension inend stage renal disease patients on hemodialysis, with 95% confidence interval and 6% margin of error, using WHO software. Moreover non-probability consecutive sampling technique was used for sample collection.Results: Our study shows that mean age was 52 years with SD ± 8.21. Fifty five percent patients were male and 73(45%) patientswere female. Forty eight percent patients had pulmonary hypertension.Conclusion: Our study concludes that the incidence of pulmonary hypertension was found to be one of the major contributingfactor among end stage renal disease patients on hemodialysis in our population.


2020 ◽  
Vol 164 ◽  
pp. 105905
Author(s):  
Joe Devasahayam ◽  
Tony Oliver ◽  
Valentina Joseph ◽  
Sudheer Nambiar ◽  
Kulothungan Gunasekaran

2008 ◽  
Vol 2 (2) ◽  
pp. 49-53 ◽  
Author(s):  
Mordechai Yigla ◽  
Regina Banderski ◽  
Zaher S. Azzam ◽  
Shimon A. Reisner ◽  
Farid Nakhoul

2018 ◽  
Vol 32 (6) ◽  
pp. e13270 ◽  
Author(s):  
Jonathan D. Wolfe ◽  
Gavin W. Hickey ◽  
Andrew D. Althouse ◽  
Michael S. Sharbaugh ◽  
Dustin E. Kliner ◽  
...  

2011 ◽  
Vol 6 (3) ◽  
pp. 155 ◽  
Author(s):  
Serife Bozbas ◽  
Suleyman Kanyilmaz ◽  
Sule Akcay ◽  
Huseyin Bozbas ◽  
Cihan Altin ◽  
...  

2005 ◽  
Vol 289 (4) ◽  
pp. F679-F684 ◽  
Author(s):  
Christopher T. Chan ◽  
Shu Hong Li ◽  
Subodh Verma

Cardiovascular disease is the principal cause of death in end-stage renal disease (ESRD) patients. Endothelial progenitor cells (EPCs) play a critical role in vascular repair, and improving EPC biology represents a novel therapeutic target. Three groups of age- and gender-matched patients were studied: 1) 10 healthy control, 2) 12 conventional hemodialysis (CHD) patients, and 3) 10 nocturnal hemodialysis (NHD) patients. EPC number and migratory function were assessed. Left ventricular mass index (LVMI) was derived, and correlations between EPC biology, uremic clearance, and LVMI were made. Compared with controls, EPC number and function were markedly impaired in CHD patients [(3.48 ± 1.2 vs. 0.86 ± 0.20%/50,000 cells, P < 0.05) and (18.8 ± 2.64 vs. 3.75 ± 0.34 cells/high-power field, P < 0.05), respectively]. In contrast, EPC number and function were normal in NHD patients [(3.48 ± 1.17 vs. 3.83 ± 0.77%/50,000 cells) and (18.8 ± 2.6 vs. 22.2 ± 2.4 cells/high-power field), respectively]. Among ESRD patients, EPC number and function inversely correlated with predialysis urea concentration ( r = −0.40; r = −0.57), LVMI ( r = −0.41; −0.46) and systolic BP ( r = −0.58; r = −0.44). We demonstrate that NHD is associated with restoration of abnormal EPC biology in ESRD. Given the increasing importance of EPCs in the repair and restoration of cardiovascular function, these data have important clinical implications for vascular risk in ESRD patients.


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