scholarly journals INFLAMMATORY AND HEMOSTATIC RISK FACTORS AND CORONARY ARTERY CALCIFICATION IN WOMEN OF BLACK AND WHITE RACE IN THE MENOPAUSAL TRANSITION: THE STUDY OF WOMEN'S HEALTH ACROSS THE NATION (SWAN) HEART STUDY

2014 ◽  
Vol 63 (12) ◽  
pp. A1410
Author(s):  
Norman C. Wang ◽  
Karen A. Matthews ◽  
Emma JM Barinas-Mitchell ◽  
Chung-Chou H. Chang ◽  
Samar R. El Khoudary
Keyword(s):  
Risk Factors ◽  
Coronary Artery ◽  
Women’S Health ◽  
Women's Health ◽  
Coronary Artery Calcification ◽  
Menopausal Transition ◽  
White Race ◽  
Black And White ◽  
Heart Study

scholarly journals Serum Urate Is Not Associated with Coronary Artery Calcification: The NHLBI Family Heart Study

2010 ◽  
Vol 38 (1) ◽  
pp. 111-117 ◽  
Author(s):  
TUHINA NEOGI ◽  
ROBERT TERKELTAUB ◽  
R. CURTIS ELLISON ◽  
STEVEN HUNT ◽  
YUQING ZHANG
Keyword(s):  
Risk Factors ◽  
Coronary Artery ◽  
Vascular Remodeling ◽  
Coronary Artery Calcification ◽  
Carotid Atherosclerosis ◽  
Helical Ct ◽  
Arterial Calcification ◽  
Helical Computed Tomography ◽  
Family Heart Study ◽  
Heart Study

Objective.Urate may have effects on vascular remodeling and atherosclerosis. We had shown an association between serum uric acid (SUA) and carotid atherosclerotic plaques. Inflammation and vascular remodeling in atherosclerosis promote coronary artery calcification (CAC), a preclinical marker for atherosclerosis. Here, we examined whether SUA is associated with CAC, using the same study sample and methods as for our previous carotid atherosclerosis study.Methods.The National Heart, Lung, and Blood Institute Family Heart Study is a multicenter study designed to assess risk factors for heart disease. Participants were recruited from population-based cohorts in the US states of Massachusetts, North Carolina, Minnesota, Utah, and Alabama. CAC was assessed with helical computed tomography (CT). We conducted sex-specific and family-cluster analyses, as well as additional analyses among persons without risk factors related to both cardiovascular disease and hyperuricemia, adjusting for potential confounders as we had in the previous study of carotid atherosclerosis.Results.For the CAC study, 2412 subjects had both SUA and helical CT results available (55% women, age 58 ± 13 yrs, body mass index 27.6 ± 5.3). We found no association of SUA with CAC in men or women [OR in men: 1.0, 1.11, 0.86, 0.90; women: 1.0, 0.83, 1.00, 0.87 for increasing categories of SUA: < 5 (referent group), 5 to < 6, 6 to < 6.8, ≥ 6.8 mg/dl, respectively], nor in subgroup analyses.Conclusion.Replicating the methods used to demonstrate an association of SUA with carotid atherosclerosis did not reveal any association between SUA and CAC, suggesting that SUA likely does not contribute to atherosclerosis through effects on arterial calcification. The possibility that urate has divergent pathophysiologic effects on atherosclerosis and artery calcification merits further study.

scholarly journals Inflammatory/Hemostatic Biomarkers and Coronary Artery Calcium Progression in Women at Midlife (from the Study of Women's Health Across the Nation, Heart Study)

2016 ◽  
Vol 118 (3) ◽  
pp. 311-318 ◽  
Author(s):  
Norman C. Wang ◽  
Karen A. Matthews ◽  
Emma J.M. Barinas-Mitchell ◽  
Chung-Chou H. Chang ◽  
Samar R. El Khoudary
Keyword(s):  
Coronary Artery ◽  
Women’S Health ◽  
Women's Health ◽  
Coronary Artery Calcium ◽  
Heart Study

Abstract P186: Quality of Total Heart Adipose Tissue May Contribute to the Presence and Extent of Coronary Artery Calcification in Women at Midlife: The Study of Women’s Health Across the Nation

Circulation ◽  
2015 ◽  
Vol 131 (suppl_1) ◽  
Author(s):  
Carrie L Hanley ◽  
Karen Matthews ◽  
Maria M Brooks ◽  
Imke Janssen ◽  
Matthew J Budoff ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Coronary Artery ◽  
Women’S Health ◽  
Women's Health ◽  
Coronary Artery Calcification ◽  
Agatston Score ◽  
Tobit Regression ◽  
Cvd Risk ◽  
Fat Depots

Background: The location and quantity of specific adipose tissue depots have been shown to be independent predictors of subclinical atherosclerosis. Most recently, attention has been focused on the quality of these fat depots as a novel marker of CVD risk. Adipose tissue attenuation, measured via radiodensity in computed tomography (CT) Hounsfield units (HU), is one such marker of fat quality. Our objective was to determine the cross-sectional association between total heart adipose tissue (TAT) radiodensity and coronary artery calcification (CAC) in women at midlife, a time period marked with an increase in CVD risk. Methods: Participants from the Study of Women’s Health Across the Nation (SWAN) Ectopic Cardiovascular Fat Ancillary Study were evaluated. CAC and TAT were measured using electron-beam CT. CAC was evaluated as 1) presence of CAC (CAC Agatston score >10), and 2) extent of CAC (continuous Agatston score). TAT radiodensity was evaluated as tertiles of HU (lowest tertile, -91 to -81 HU; middle tertile, -80 to -78 HU; highest tertile -77 to -67 HU). Logistic (for CAC presence) and Tobit regression (for CAC extent) were used for statistical analyses. Results: A total of 495 women with a mean age of 51 years were examined. This sample of women was 63% white, 37% black, 54% pre-/early peri-menopausal, 35% late peri-/postmenopausal, and 11% used hormones. In unadjusted logistic and Tobit regression models ( Table 1 ), the tertiles of TAT were significantly and inversely associated with the presence and extent of CAC. In fully adjusted models, the middle tertile remained significantly inversely associated with the presence and extent of CAC compared to the lowest tertile, but the adjusted estimates for the highest tertile were attenuated and non-significant ( Table 1 ). Conclusions: There appears to be an inverse relationship between TAT radiodensity and CAC which is more pronounced for those with mid-range radiodensity values. These results merit further investigation.

Abstract P325: Association of Risk Factors and Extra-coronary Atherosclerosis with Progression of Coronary Artery Calcification in the Framingham Heart Study

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Oyere K Onuma ◽  
Karol M Pencina ◽  
Joseph M Massaro ◽  
Udo Hoffman ◽  
Christopher J O'Donnell
Keyword(s):  
Risk Factors ◽  
Coronary Artery ◽  
Framingham Heart Study ◽  
Coronary Artery Calcification ◽  
Ct Scanning ◽  
Linear Regression Models ◽  
Cvd Risk ◽  
Abdominal Aortic ◽  
Heart Study

Background: Progression of coronary artery calcification (CAC) is associated with future incidence of adverse cardiovascular disease. However, the interplay of CAC progression and atherosclerosis in different vascular beds has been less studied. We tested for the association of risk factors and baseline abdominal aortic calcification (AAC) with CAC progression in a large community cohort. Methods: We determined risk factors, baseline AAC/CAC, and CAC progression in a sample of 1994 asymptomatic white participants from the Framingham Heart Study (FHS) who had undergone serial CT scanning within an average of 6.1 years. The primary outcomes were: (a) incident calcification (CAC > 0) in participants free of CAC at baseline; and (b) absolute progression of CAC (CAC follow-up > CAC baseline) in participants with detectable baseline CAC. To test the effect of risk factors and baseline AAC/CAC on CAC progression, we employed multivariable stepwise logistic and linear regression models of CAC progression with/without AAC, adjusted for traditional CVD risk factors. Results: There were 1118 participants free of CAC at the baseline scan, of which 18.8% developed CAC in the follow-up scan. Of the 776 participants with detectable CAC at baseline, 84.9% developed progression of baseline CAC. In both subsets, AAC was a highly significant predictor of CAC incidence or progression, independent of other risk factors. Of note, the stepwise model including baseline AAC as a candidate for entry resulted in the same set of non-AAC predictors of CAC incidence or progression as the model without AAC. Table 1 displays the final logistic regression results for the cohort free of CAC. The AUC improved to 0.738 compared to an AUC of 0.722 for the model without AAC (p=0.002). Conclusion: AAC is a strong independent predictor of CAC progression determined by incident CAC and CAC progression. Addition of AAC to the model that predicts incident CAC improves discrimination in a cohort free of baseline CAC.

Association of Plasma MiRNA-204 and the Presence and Severity of Coronary Artery Calcification in Patients With Type 2 Diabetes

Angiology ◽  
2021 ◽  
pp. 000331972098459
Author(s):  
Yao-dong Ding ◽  
Yu-qiang Pei ◽  
Rui-Wang ◽  
Jia-xin Yang ◽  
Ying-xin Zhao ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Coronary Artery ◽  
Coronary Artery Calcification ◽  
Characteristic Curve ◽  
Glycosylated Hemoglobin ◽  
The United Kingdom ◽  
Traditional Risk Factors ◽  
Plasma Microrna

We investigated the association between plasma microRNA (miR)-204 and coronary artery calcification (CAC) in patients with type 2 diabetes mellitus (T2DM). We consecutively enrolled 179 individuals with T2DM who underwent coronary computed tomography at Anzhen Hospital from January 2015 to September 2016. The CAC score (CACS) was expressed in Agatston units and >10 Hounsfield units were defined as CAC-positive status. Significant CAC was observed in 98 (54.7%) patients. Plasma miR-204 levels (relative expression) were significantly lower in patients with significant CAC than controls (1.001 ± 0.100 vs 0.634 ± 0.211, P < .001). Plasma miR-204 levels were also negatively correlated with the glycosylated hemoglobin A1c (HbA1c) level (r = −0.702, P < .001), CACS (r = −0.710, P < .001), and the United Kingdom Prospective Diabetes Study (UKPDS) score (r = −0.355, P < .001). After multivariate logistic analyses, plasma miR-204 levels were still significantly and independently associated with the presence of CAC (odds ratio = 0.103, CI = 0.018-0.583, P < .001) after adjustment for conventional risk factors. Receiver operating characteristic curve analysis showed that plasma miR-204 levels can predict the severity and extent of CAC, and the specificity was higher than that of the traditional risk factors UKPDS score and HbA1c. In conclusion, the downregulation of miR-204 was independently associated with CAC in patients with T2DM.

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