LEFT VENTRICULAR EJECTION FRACTION TRAJECTORIES IN ACUTE DECOMPENSATED SYSTOLIC HEART FAILURE IS ASSOCIATED WITH ADVERSE OUTCOMES

2019 ◽  
Vol 73 (9) ◽  
pp. 939
Author(s):  
Sula Mazimba ◽  
Douglas Sawch ◽  
Anita Barber ◽  
Sthuthi David ◽  
Corey Benjamin ◽  
...  
Keyword(s):  
Heart Failure ◽  
Left Ventricular Ejection Fraction ◽  
Ejection Fraction ◽  
Systolic Heart Failure ◽  
Left Ventricular ◽  
Adverse Outcomes ◽  
Ventricular Ejection ◽  
Left Ventricular Ejection ◽  
Ventricular Ejection Fraction

ACCESSMENT OF RIGHT VENTRICULAR SYSTOLIC FUNCTION USING TAPSE

2011 ◽  
pp. 62-70
Author(s):  
Lien Nhut Nguyen ◽  
Anh Vu Nguyen
Keyword(s):  
Heart Failure ◽  
Left Ventricular Ejection Fraction ◽  
Ejection Fraction ◽  
Right Ventricular ◽  
Systolic Function ◽  
Systolic Heart Failure ◽  
Left Ventricular ◽  
Ventricular Ejection ◽  
Left Ventricular Ejection ◽  
Ventricular Ejection Fraction

Background: The prognostic importance of right ventricular (RV) dysfunction has been suggested in patients with systolic heart failure (due to primary or secondary dilated cardiomyopathy - DCM). Tricuspid annular plane systolic excursion (TAPSE) is a simple, feasible, reality, non-invasive measurement by transthoracic echocardiography for evaluating RV systolic function. Objectives: To evaluate TAPSE in patients with primary or secondary DCM who have left ventricular ejection fraction ≤ 40% and to find the relation between TAPSE and LVEF, LVDd, RVDd, RVDd/LVDd, RA size, severity of TR and PAPs. Materials and Methods: 61 patients (36 males, 59%) mean age 58.6 ± 14.4 years old with clinical signs and symtomps of chronic heart failure which caused by primary or secondary DCM and LVEF ≤ 40% and 30 healthy subject (15 males, 50%) mean age 57.1 ± 16.8 were included in this study. All patients and controls were underwent echocardiographic examination by M-mode, two dimentional, convensional Dopler and TAPSE. Results: TAPSE is significant low in patients compare with the controls (13.93±2.78 mm vs 23.57± 1.60mm, p<0.001). TAPSE is linearly positive correlate with echocardiographic left ventricular ejection fraction (r= 0,43; p<0,001) and linearly negative correlate with RVDd (r= -0.39; p<0.01), RVDd/LVDd (r=-0.33; p<0.01), RA size (r=-0.35; p<0.01), TR (r=-0.26; p<0.05); however, no correlation was found with LVDd and PAPs. Conclusions: 1. Decreased RV systolic function as estimated by TAPSE in patients with systolic heart failure primary and secondary DCM) compare with controls. 2. TAPSE is linearly positive correlate with LVEF (r= 0.43; p<0.001) and linearly negative correlate with RVDd (r= -0.39; p<0.01), RVDd/LVDd (r=-0.33; p<0.01), RA size (r=-0.35; p<0.01), TR (r=-0.26; p<0.05); however, no correlation is found with LVDd and PAPs. 3. TAPSE should be used routinely as a simple, feasible, reality method of estimating RV function in the patients systolic heart failure DCM (primary and secondary).

scholarly journals Penurunan Fraksi Ejeksi Ventrikel Kiri dalam Enam Bulan Meningkatkan Faktor Resiko Gangguan Kognitif Penderita Gagal Jantung Sistolik

2020 ◽  
Vol 9 (1) ◽  
pp. 94
Author(s):  
Risky Ilona Saputra ◽  
I Made Oka Adnyana ◽  
AAA Putri Laksmidewi ◽  
Anna Marita Gelgel ◽  
I Putu Eka Widyadharma
Keyword(s):  
Heart Failure ◽  
Cognitive Function ◽  
Left Ventricular Ejection Fraction ◽  
Ejection Fraction ◽  
Systolic Heart Failure ◽  
Left Ventricular ◽  
Ventricular Ejection ◽  
Left Ventricular Ejection ◽  
Ventricular Ejection Fraction ◽  
Function Impairment

AbstrakGangguan kognitif sering dijumpai pada penderita gagal jantung sistolik dan tidak terdeteksi sejak awal. Hal ini memperburuk kondisi dan luaran klinis penderita. Penelitian ini bertujuan untuk mengetahui adanya peningkatan risiko terjadinya gangguan kognitif pada penderita gagal jantung sistolik dengan penurunan fraksi ejeksi ventrikel kiri dalam enam bulan. Metode penelitian ini adalah kontrol kasus, di Poli Jantung dan Poli Saraf RSUP Sanglah, Denpasar, periode Oktober 2018 hingga Desember 2018. Analisis data dilakukan dengan SPSS versi 22. Penelitian ini menggunakan 76 subjek, dengan rerata usia 50,3 ± 4,5 tahun. Karakteristik yang lebih dominan dijumpai pada jenis kelamin laki-laki 44 orang (57,9%), pendidikan ≥ 12 tahun 40 orang (52,6%), dan pekerjaan formal 40 orang (52,6%) Dari hasil analisis statistik didapatkan persentase penurunan fungsi kognitif pada kelompok kasus sebesar 89,5% sedangkan pada kelompok kontrol didapatkan 13,2%. Analisis bivariat dengan Chi-square, didapatkan nilai OR=56,1; IK 95% 13,844-227,338; p<0,001. Pada analisis multivariat didapatkan penurunan FEVK dalam enam bulan merupakan faktor risiko yang kuat, memiliki risiko mengalami gangguan kognitif pada penderita gagal jantung sistolik dengan adjusted OR=23,1, setelah mengendalikan jenis kelamin, pendidikan dan pekerjaan, OR=23,1; IK 95% 4,7-114,03; p<0,001. Penelitian ini menyimpulkan bahwa penurunan FEVK dalam enam bulan sebagai faktor risiko gangguan kognitif penderita gagal jantung sistolik. Penulis menyarankan para klinisi perlu melakukan pemeriksaan fungsi kognitif pada penderita gagal jantung sistolik .Kata kunci: gangguan kognitif, penurunan FEVK, gagal jantung sistolikAbstract Cognitive impairment was common finding in systolic heart failure patient and also not early detected. it produced negative effect and worsening outcome. This study aims to determine increased of risk cognitive function impairment in systolic heart failure patient with decreased left ventricular ejection fraction in six months. The study used a case-control design, in Cardiologi and Neurologi Clinic Sanglah Hospital, Denpasar, from October 2018 to December 2018. Data was analized using SPSS version 22. A total of 76 subjects were recruited. The mean age was 50,3 ± 4,5years, more dominant in male sex (n=44, 57,9%), study ≥ 12 years (n=40, 52,6%), formal occupation (n=40, 52,6%). From the statistical analysis it was found that the percentase of cognitive impairment in case group 89,5% and 13,2% in control group. Bivariate analysis with Chi-square (OR=56,1: CI95%=13,844-227,338: p<0,001). There was a significant association between increased of cognitive function impairment and decreased left ventricular ejection fraction in six months in systolic heart failure patient. From the multivariate analysis, it was found that the decreased left ventricular ejection fraction in six months, which allowed a 23 times greater risk cognitive function impairment in systolic heart failure patients ( adjusted OR=23,1: CI95% =4,7-114,03: p<0,001). We conclude that increased cognitive function impairment twenty four folds in systolic heart failure patient with decreased left ventricular ejection fraction in six months in Sanglah General Hospital statistically significant. The author suggest that clinicians need to consider doing congnitive function examination in in systolic heart failure patient.Keywords: cognitive function, decreased left ventricular ejection fraction, systolic heart failure

scholarly journals Clinical Implications of Sodium Zirconium Cyclosilicate Therapy in Patients with Systolic Heart Failure and Hyperkalemia

2021 ◽  
Vol 10 (23) ◽  
pp. 5523
Author(s):  
Teruhiko Imamura ◽  
Akira Oshima ◽  
Nikhil Narang ◽  
Koichiro Kinugawa
Keyword(s):  
Heart Failure ◽  
Left Ventricular Ejection Fraction ◽  
Ejection Fraction ◽  
Systolic Heart Failure ◽  
Left Ventricular ◽  
Ventricular Ejection ◽  
Left Ventricular Ejection ◽  
Renin Angiotensin Aldosterone System ◽  
Ventricular Ejection Fraction ◽  
Renin Angiotensin

Background: Sodium zirconium cyclosilicate (SZC), a newly introduced specific potassium binder, is introduced to treat hyperkalemia. However, the implications of SZC in up-titrating renin–angiotensin–aldosterone system inhibitors in patients with systolic heart failure remain unknown. Methods and Results: Patients with heart failure with left ventricular ejection fraction <50% and hyperkalemia who had completed 3-month SZC therapy were retrospectively included. Serum potassium levels, the dose of renin–angiotensin–aldosterone system inhibitors, and echocardiographic parameters during the 3-month SZC therapy as compared with the pretreatment 3-month period were investigated. A total of 24 patients (median 77 years old, 71% men, median left ventricular ejection fraction 41%) received a 3-month SZC therapy without any associated adverse events including hypokalemia. Compared with the pretreatment period, serum potassium levels decreased, doses of renin–angiotensin–aldosterone system inhibitors increased, and the left ventricular ejection fraction and plasma B-type natriuretic peptide levels improved following the 3-month SZC therapy (p < 0.05 for all). Conclusions: SZC may be a promising therapeutic option to improve hyperkalemia, indirectly allowing up-titration of renin–angiotensin–aldosterone system inhibitors and facilitating reverse remodeling in patients with heart failure with a left ventricular ejection fraction <50% and hyperkalemia.

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