Expression and Regulation of a Novel Collagen-binding Heat Shock Protein in Vascular Lesion Formation

1998 ◽  
Vol 31 (2) ◽  
pp. 420A
Author(s):  
E Rocnik
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Vascular Lesion ◽  
Lesion Formation ◽  
Collagen Binding

Two stress proteins of the endoplasmic reticulum bind denatured collagen

1990 ◽  
Vol 68 (7-8) ◽  
pp. 1057-1061 ◽  
Author(s):  
Devki Nandan ◽  
Eric H. Ball ◽  
Bishnu D. Sanwal
Keyword(s):  
Endoplasmic Reticulum ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Protein Level ◽  
Stress Proteins ◽  
Fold Increase ◽  
Low Ph ◽  
Simple Method ◽  
Collagen Binding ◽  
Glucose Regulated Protein

A differentiation-related gelatin-binding 46 kilodalton (kDa) glycoprotein in myoblasts (GP46, colligin) shares several properties with the 78-kDa glucose-regulated protein (GRP78), including location in the endoplasmic reticulum and related C-terminal sequences. These similarities extend to stress inducibility, since we find that GP46 is a heat-shock protein; its synthesis is elevated at 42 °C, resulting in a two- to three-fold increase in protein level. Further, GRP78 is a gelatin-binding protein; together with GP46 it is retained on gelatin–Sepharose beads. GRP78 and GP46 do not interact; each protein can be individually eluted, GP46 at low pH and GRP78 by ATP. These results suggest that the proteins have distinct roles in the synthesis of collagen and point to a simple method for purification.Key words: stress proteins, collagen-binding proteins, endoplasmic reticulum, 78-kilodalton glucose-regulated protein, 46-kilodalton glycoprotein.

Collagen-binding heat shock protein HSP47 expression during healing of fetal skin wounds

2002 ◽  
Vol 31 (2) ◽  
pp. 179-184 ◽  
Author(s):  
Z.-L. Wang ◽  
T. Inokuchi ◽  
H. Ikeda ◽  
T.T. Baba ◽  
M. Uehara ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Skin Wounds ◽  
Fetal Skin ◽  
Collagen Binding

REGULATION AND FUNCTION OF COLLAGEN-BINDING HEAT SHOCK PROTEIN: HSP47

1991 ◽  
pp. 64
Author(s):  
K. NAGATA ◽  
H. KUDO ◽  
H. TAKECHI ◽  
A. NAKAI ◽  
M. SATO ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Collagen Binding ◽  
And Function
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