G60 Effects of amlodipine and nifedipine retard on 24-hour blood pressure, heart rate and autonomic nerve activities in hypertensive patients

Introduction: Hypertension is independent and the most powerful predictor of cardiovascular morbidity and mortality. Sympathetic overdrive may be related to essential hypertension. Heart Rate Variability (HRV) analysis is one of the most quantitative markers of autonomic activity in hypertensive patients. Objective: To assess the cardiac autonomic nerve function status by heart rate variability in essential hypertension. Materials and Methods: This cross sectional study was carried out to observe the HRV in 60 hypertensive male patients with age ranging from 40-60 years (group B) in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU) from 1st July 2008 to 30th June 2009. Based on treatment, hypertensive patients were divided into B1 (untreated patients on their 1st day of diagnosis) and B2 (patients with antihypertensive therapy for less than 5 years). For comparison, 30 apparently healthy normotensive subjects (group A) matched by age sex were also studied. The study group was selected from the Out Patient Department of Cardiology, BSMMU, Dhaka and the control group was selected by personal contact. Heart Rate Variability parameters were assessed by Polygraph (RMS Polyrite D, version2.2) and for statistical analysis Independent sample t-test, One-way ANOVA test, Chi-square test and Pearson’s correlation coefficient tests were done as applicable. Results: LF/HF(Low Frequency/High Frequency) ratio and LF norm (normalized unit) were significantly (p<0.001) higher and HF norm was significantly (p<0.001) lower in untreated hypertensive patients in comparison to those of healthy normotensive subjects. parameters were observed between treated hypertensive and healthy control subjects. The LF/HF ratio and LF norm showed positive correlations and HF norm showed negative correlations with SBP (systolic blood pressure) and DBP (diastolic blood pressure) in both the hypertensive groups. However, all these findings were more marked in untreated hypertensive patients than those of treated group. Conclusion: Hypertensive patients may have sympathovagal imbalance and is usually characterized by higher sympathetic as well as lower vagal modulation of the heart rate. Journal of Armed Forces Medical College Bangladesh Vol.12(1) 2016: 38-43

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Ramadan and blood pressure: importance of chronotherapy

European Journal of Preventive Cardiology ◽

10.1093/eurjpc/zwab061.154 ◽

2021 ◽

Vol 28 (Supplement_1) ◽

Author(s):

MA Bejar ◽

I Zairi ◽

I Ben Mrad ◽

B Besbes ◽

K Mzoughi ◽

...

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Dual Therapy ◽

Average Heart Rate ◽

Hypertensive Patients ◽

Mean Values ◽

Funding Sources ◽

Cardiology Department ◽

Group 2 ◽

And Gender

Abstract Funding Acknowledgements Type of funding sources: None. Background During Ramadan, alterations in the daily patterns of sleep, activities and medication timing might contribute to changes in blood pressure (BP) and heart rate among hypertensive patients. The aim of this study was to examine the effect of medication timing during Ramadan on blood pressure and heart rate in hypertensive subjects taking their treatment once daily. Methods The study prospectively recruited 44 hypertensive patients between April and June 2019, followed up at the cardiology department of our Hospital. A 24-hour pressure monitoring was carried out during two periods: prior to Ramadan and during the last ten days of Ramadan. Results We studied 29 women and 15 men, mean age was 58.7 years. 34% of the patients were diabetics and 16% had coronaropathy. 46% of the patients were on monotherapy, 43% on dual therapy and 11% on a triple antihypertensive therapy. During Ramadan, 57% of the patients took their treatment during the dinner (group1), whereas 43% took their treatment during the Shour (group 2). Average 24hour blood pressure in the whole group was 129 ± 18/74 ± 10 mmHg before Ramadan and 129 ± 19/74 ± 10 mmHg during Ramadan (p > 0.05). Daytime and nighttime mean values of systolic and diastolic blood pressure as well as mean values of heart rate were not different between both periods regardless of age and gender. However, during Ramadan, those who took their treatment after dinner had significant higher values of 24 hour systolic BP, awake systolic and diastolic BP, asleep systolic and diastolic BP than those who took their treatment with the shour (p < 0.05). Conclusion In this study, there were no significant changes in systolic and diastolic blood pressures as well as heart rate during the 2 periods. However, during Ramadan, a slight superiority of taking the treatment with the shour is observed. Average values of BP and heart rate Group 1 Group 2 p 24 hour SBP (mmHg) 134 ± 23 122 ± 6 0.017 24 hour DBP (mmHg) 76 ± 12 70 ± 5 0.052 Awake SBP (mmHg) 138 ± 23 125 ± 6 0.012 Awake DBP (mmHg) 79 ± 12 73 ± 5 0.044 Asleep SBP (mmHg) 127 ± 26 114 ± 12 0.030 Asleep DBP (mmHg) 71 ± 13 65 ± 7 0.045 24 hour average heart rate (bpm) 71 ± 7 70 ± 6 0.524 Awake average heart rate (bpm) 76 ± 7 74 ± 7 0.322 Asleep average heart rate (bpm) 65 ± 7 65 ± 7 0.931 Average values of blood pressure and heart rate in both groups Abstract Figure. 24hour course of blood pressure

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Enalapril versus combined enalapril and nadolol treatment: Effects on blood pressure, heart rate, humoral variables, and plasma potassium at rest and during exercise in hypertensive patients

Cardiovascular Drugs and Therapy ◽

10.1007/bf00051148 ◽

1992 ◽

Vol 6 (3) ◽

pp. 261-265 ◽

Cited By ~ 1

Author(s):

Patrick A. Sullivan ◽

Bertie Daly ◽

Ray O'Connor

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Treatment Effects ◽

Plasma Potassium ◽

Hypertensive Patients

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The Effects of Pneumoperitoneum on Heart Rate, Mean Arterial Blood Pressure and Cardiac Output of Hypertensive Patients during Laparoscopic Colectomy

Journal of Korean Academy of Nursing ◽

10.4040/jkan.2010.40.3.433 ◽

2010 ◽

Vol 40 (3) ◽

pp. 433

Author(s):

Eun Ju Kim ◽

Haesang Yoon

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Cardiac Output ◽

Arterial Blood Pressure ◽

Laparoscopic Colectomy ◽

Mean Arterial Blood Pressure ◽

Hypertensive Patients ◽

Arterial Blood

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An observational comparative study of different doses of azilsartan and with chlorthalidone combination in moderate hypertension

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20190144 ◽

2019 ◽

Vol 8 (2) ◽

pp. 259

Author(s):

Tamoghna Maiti ◽

Sonai Mandal ◽

Ratul Banerjee ◽

Sourav Chakrabarty ◽

Amrita Panda

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Antihypertensive Agents ◽

Fixed Dose ◽

High Dose ◽

Hypertensive Patients ◽

Medical College ◽

Fda Approval ◽

High Prevalence ◽

Dose Combination

Background: High blood pressure (BP) is one of the significant non-communicable diseases that are of high prevalence in our country. Hypertension (HTN) is responsible cause of 57% of stroke and 24% of coronary heart disease deaths in India. Eight classes of medications are currently used in the treatment of hypertension. Azilsartan medoxomil is a newly added FDA approved drug to the ARB class of antihypertensive agents. azilsartan and chlorthalidone combination is also got the FDA approval. There is limited study in between these two groups regarding efficacy especially in rural Bengal.Methods: A prospective observational study was done in medicine OPD of Bankura Sammilani Medical College for twelve weeks with two groups that are azilsartan (80mg) and fixed dose combination of azilsartan (40mg) plus chlorthalidone (12.5mg) in the age group of 18 to 55years of moderate hypertensive patients. Change of heart rate was assessed as safety parameter.Results: It was found that both the group of drugs are very much effective in lowering blood pressure constantly in respect of both systolic and diastolic BP but azilsartan monotherapy in high dose reduce systolic blood pressure slightly high. Significant change of heart rate was not seen with both the groups.Conclusions: Both the group was effective as well as safe in hypertensive patients.

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PO-186 Effects of Shaolin Ba Duan Jin on Hypertensive Patients

Exercise Biochemistry Review ◽

10.14428/ebr.v1i4.12793 ◽

2018 ◽

Vol 1 (4) ◽

Author(s):

Xianfeng Hua

Keyword(s):

Quality Of Life ◽

Blood Pressure ◽

Heart Rate ◽

Martial Arts ◽

Hypertensive Patients ◽

Quality Of Life Scale ◽

Before And After ◽

Life Scale ◽

Blood Pressures

Objective To investigate the effects of Shaolin Ba Duan Jin on patients with hypertension. Methods In the hypertensive patients detected in the national physical fitness test of public officials in Guiyang City, 40 patients with hypertension were selected. The experiment was started after Shaolin Ba Duan Jin has been practiced for seven days and the subjects had learned it. Experimental method: Frequency of subjects practicing Ba Duan Jin is 7 days a week, subjects practice once a day, practicing time is 6:00-7:30 am or 18:00 -19:30 pm, practicing lasts 1.5 hours each time (practicing has 3 groups, 14 minutes in each group；subjects rest 2 minutes between groups,；preparing part is 8 minutes；ending part is 5 minutes), record the blood pressure of the subjects before and after each experiment, and fill in the quality of life scale (WHOQOL-BREF scale) regularly for a period of 12 weeks. Questionnaire method: Fill in the quality of life scale every three weeks and measure heart rate and blood pressure before and after each exercise. Mathematical statistics: The paired sample t test was used to analyze the changes in blood pressure before and after the 12-week experiment. Results 1) The systolic and diastolic blood pressures of the subjects were significantly lower than before the experiment (P <0.01). 2) The WHOQOL-BREF scale after 12 weeks has improved significantly in all areas than before the experiment. Conclusions 1) Martial arts Ba Duan Jin has a good influence on the circulatory system of hypertensive patients. The performance is that the heart rate is slow and the systolic and diastolic blood pressures have a downward trend. 2) Martial arts Ba Duan Jin has significant improvement in the physiology, psychology, social relations, environment and other fields .

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