RATIONALE AND BASELINE CHARACTERISTICS OF PREVENT: A SECOND GENERATION INTERVENTION TRIAL IN SUBJECTS AT-RISK (PRODROMAL) OF DEVELOPING FIRST EPISODE PSYCHOSIS EVALUATING COGNITIVE BEHAVIOUR THERAPY, ARIPIPRAZOLE AND PLACEBO FOR THE PREVENTION OF PSYCHOSIS

Objective: This paper outlines a rationale for expanding research and clinical innovations focused upon relapse prevention following a first episode of psychosis. Some general principles for further progress are extracted from an overview of the first-episode psychosis (FEP) relapse literature. A cognitive behaviour therapy intervention for relapse prevention for FEP, that has been developed at the Early Psychosis Prevention and Intervention Centre, is described to illustrate these principles. Conclusions: Further progress is needed in refining interventions specific to the prevention of relapse following FEP. Future progress is dependent upon improved understanding of the interaction of biological, interpersonal and psychological processes underpinning relapse.

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The Credibility and Acceptability of Befriending as a Control Therapy in a Randomized Controlled Trial of Cognitive Behaviour Therapy for Acute First Episode Psychosis

Behavioural and Cognitive Psychotherapy ◽

10.1017/s1352465806002815 ◽

2006 ◽

Vol 34 (3) ◽

pp. 277-291 ◽

Cited By ~ 27

Author(s):

Sarah Bendall ◽

Henry J. Jackson ◽

Eoin Killackey ◽

Kelly Allott ◽

Tracy Johnson ◽

...

Keyword(s):

Controlled Trial ◽

First Episode Psychosis ◽

Drop Out ◽

Control Treatment ◽

First Episode ◽

Future Research ◽

Behaviour Therapy ◽

Episode Psychosis ◽

Cognitive Behaviour ◽

Control Therapy

There is increasing evidence that cognitive behavioural therapy (CBT) is efficacious in treating psychosis. However, very little attention has been paid to the nature of the control treatments used in studies of this. Befriending has been used as a control treatment in several randomized control trials (RCTs) of CBT for psychosis as it is simple to learn and administer. The aim of the present study was to examine whether Befriending controlled for important non-specific aspects of therapy when compared to CBT in a RCT for acute first episode psychosis (FEP). These non-specific factors included time in, expectancy created by, and acceptability of therapy. Expectations and enjoyment of therapy were measured by questionnaire. Time in therapy and the number of drop-outs were also recorded. Results showed that Befriending was comparable to CBT on measures of expectancy, enjoyment of therapy and drop-out rate, but significantly different with regard to time in therapy. This suggests that Befriending is a credible and acceptable control therapy for FEP with modification to increase time in therapy sessions. Methodological issues are raised, and suggestions for future research are made regarding control treatments.

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Faculty Opinions recommendation of Efficacy and safety of individual second-generation vs. first-generation antipsychotics in first-episode psychosis: a systematic review and meta-analysis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717969279.793469614 ◽

2013 ◽

Author(s):

John Davis

Keyword(s):

Systematic Review ◽

First Generation ◽

Second Generation ◽

Meta Analysis ◽

First Episode Psychosis ◽

First Episode ◽

Efficacy And Safety ◽

Episode Psychosis

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Early Psychosis Prevention and Intervention Centre long-term follow-up study of first-episode psychosis: methodology and baseline characteristics

Early Intervention in Psychiatry ◽

10.1111/j.1751-7893.2007.00008.x ◽

2007 ◽

Vol 1 (1) ◽

pp. 49-60 ◽

Cited By ~ 31

Author(s):

Lisa P. Henry ◽

Meredith G. Harris ◽

G. Paul Amminger ◽

Hok Pan Yuen ◽

Susy M. Harrigan ◽

...

Keyword(s):

First Episode Psychosis ◽

Early Psychosis ◽

First Episode ◽

Prevention And Intervention ◽

Follow Up Study ◽

Episode Psychosis ◽

Long Term Follow Up ◽

Baseline Characteristics

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Circulating lipids associate with future weight gain in individuals with an at-risk mental state and in first-episode psychosis

10.1101/2020.01.30.20019711 ◽

2020 ◽

Author(s):

Santosh Lamichhane ◽

Alex M. Dickens ◽

Partho Sen ◽

Heikki Laurikainen ◽

Jaana Suvisaari ◽

...

Keyword(s):

At Risk ◽

Weight Gain ◽

High Risk ◽

Psychotic Disorders ◽

First Episode Psychosis ◽

Molecular Signature ◽

First Episode ◽

Baseline Serum ◽

Average Life Span ◽

Episode Psychosis

AbstractPatients with schizophrenia have a lower than average life span, largely due to the increased prevalence of cardiometabolic co-morbidities. Identification of individuals with psychotic disorders with a high risk of rapid weight gain, and the associated development of metabolic complications, is an unmet need as regards public health. Here, we applied mass spectrometry-based lipidomics in a prospective study comprising 48 controls (CTR), 44 first-episode psychosis (FEP) patients and 22 individuals at clinical-high-risk (CHR) for psychosis, from two study centers (Turku/Finland and London/UK). Baseline serum samples were analyzed by lipidomics, while body mass index (BMI) was assessed at baseline and after 12 months. We found that baseline triacylglycerols with low double bond counts and carbon numbers were positively associated with the change in BMI at follow-up. In addition, a molecular signature comprised of two triacylglycerols (TG(48:0) and TG(45:0)), was predictive of weight gain in individuals with a psychotic disorder, with an area under the receiver operating characteristic curve (AUROC) of 0.74 (95% CI: 0.60–0.85). When independently tested in the CHR group, this molecular signature predicted said weight change with AUROC = 0.73 (95% CI: 0.61–0.83). We conclude that molecular lipids may serve as a predictor of weight gain in psychotic disorders in at-risk individuals, and may thus provide a useful marker for identifying individuals who are most prone to developing cardiometabolic co-morbidities.

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