FC05-04 - The gamse (grodberg autism mental status examination). Preliminary development of a standardized autism-focused exam

2011 ◽  
Vol 26 (S2) ◽  
pp. 1837-1837
Author(s):  
D. Grodberg ◽  
P. Weinger ◽  
A. Kolevzon ◽  
L. Soorya ◽  
J. Buxbaum

BackgroundThe traditional mental status examination, used universally in psychiatry, does not provide flexibility to accommodate the developmental perspective necessary for the examination of patients with Autism Spectrum Disorder (ASD). The Grodberg Autism Mental Status Examination (GAMSE), developed at the Seaver Autism Center for Research and Treatment, prompts the observation and recording of social, communicative and behavioral functioning in patients with ASD. The GAMSE contains 8 items, which produce a total score ranging from 0 to 16.Objectives1. To determine the validity of the GAMSE in accurately predicting diagnostic classification based on a gold standard observational assessment.2. To establish inter-rater reliability.MethodsEighty consecutive patients receiving autism diagnostic evaluations at the Seaver Autism Center were administered the GAMSE and the Autism Diagnostic Observation Schedule (ADOS) as part of standard intake procedures. The classification accuracy of the GAMSE was assessed using the ADOS as the gold standard. Inter-rater reliability on the GAMSE was also examined (n = 44).ResultsA receiver-operating characteristic (ROC) curve analysis was used to determine a cut-off score based on the 8 items of the GAMSE. The most effective cut-off score of greater than or equal to 5 predicted outcome on the ADOS with a sensitivity of 0.94 and a specificity of 0.81. Co-rating of 44 participants on the AMSE resulted in an average measures intra-class correlation of 0.85.ConclusionsPreliminary results indicate excellent classification accuracy and suggest that the GAMSE may act as a useful standardized autism assessment tool for clinical and research endeavors.

2012 ◽  
Author(s):  
David Grodberg ◽  
Paige M. Weinger ◽  
Alexander Kolevzon ◽  
Latha Soorya ◽  
Joseph D. Buxbaum

2017 ◽  
Vol 27 (5) ◽  
pp. 365-372 ◽  
Author(s):  
Julian Edbrooke-Childs ◽  
Jacqueline Hayes ◽  
Evelyn Sharples ◽  
Dawid Gondek ◽  
Emily Stapley ◽  
...  

Background‘Situation Awareness For Everyone’ (SAFE) was a 3-year project which aimed to improve situation awareness in clinical teams in order to detect potential deterioration and other potential risks to children on hospital wards. The key intervention was the ‘huddle’, a structured case management discussion which is central to facilitating situation awareness. This study aimed to develop an observational assessment tool to assess the team processes occurring during huddles, including the effectiveness of the huddle.MethodsA cross-sectional observational design was used to psychometrically develop the ‘Huddle Observation Tool’ (HOT) over three phases using standardised psychometric methodology. Huddles were observed across four NHS paediatric wards participating in SAFE by five researchers; two wards within specialist children hospitals and two within district general hospitals, with location, number of beds and length of stay considered to make the sample as heterogeneous as possible. Inter-rater reliability was calculated using the weighted kappa and intraclass correlation coefficient.ResultsInter-rater reliability was acceptable for the collaborative culture (weighted kappa=0.32, 95% CI 0.17 to 0.42), environment items (weighted kappa=0.78, 95% CI 0.52 to 1) and total score (intraclass correlation coefficient=0.87, 95% CI 0.68 to 0.95). It was lower for the structure and risk management items, suggesting that these were more variable in how observers rated them. However, agreement on the global score for huddles was acceptable.ConclusionWe developed an observational assessment tool to assess the team processes occurring during huddles, including the effectiveness of the huddle. Future research should examine whether observational evaluations of huddles are associated with other indicators of safety on clinical wards (eg, safety climate and incidents of patient harm), and whether scores on the HOT are associated with improved situation awareness and reductions in deterioration and adverse events in clinical settings, such as inpatient wards.


2021 ◽  
Vol 10 (19) ◽  
pp. 4374
Author(s):  
Victoria Allgar ◽  
Barry Wright ◽  
Amelia Taylor ◽  
Ann Le Couter ◽  
Helen Phillips

The aim was to investigate the agreement between the ADI-R Deaf adaptation and ADOS-2 Deaf adaptation overall diagnostic categorisation for autism (AUT) and a wider threshold to include autism spectrum (ASD) in a cohort of deaf children with and without ASD. We compared results of the instruments used on their own and when combined and propose standard criteria for the combined use of the ADI-R Deaf adaptation and ADOS-2 Deaf adaptation for use with deaf children. In total, 116 deaf children had a Gold standard NICE guideline assessment; 58 diagnosed with ASD and 58 without ASD, and for both groups a blinded informant based ADI-R Deaf adaptation and direct assessment using the ADOS-2 Deaf adaptation were separately completed. There was moderate agreement between the ADI-R Deaf adaptation and ADOS-2 Deaf adaptation for the wider threshold of ASD (Kappa, 0.433). To achieve the lowest number of false negatives, the most successful assessment tool approach is using the wider threshold of ASD with either ADI-R Deaf adaptation or ADOS-2-Deaf adaptation (95% sensitivity). This compares with 88% for the ADI-R Deaf adaptation alone and 74% for the ADOS-2-Deaf adaptation alone (wider threshold of ASD). To achieve a low number of false positives, the most successful assessment tool approach is a combination of ADI-R Deaf adaptation and ADOS-2- Deaf adaptation (using the narrow threshold of autism for both) (95% specificity). This compares with 83% for the ADI-R Deaf adaptation alone and 81% for the ADOS-2-Deaf adaptation (narrow threshold) alone. This combination is therefore recommended in specialist clinics for diagnostic assessment in deaf children.


2018 ◽  
Vol 50 (7) ◽  
pp. 2320-2325 ◽  
Author(s):  
Marlene Pereira Galdino ◽  
Luiz Fernando Longuim Pegoraro ◽  
Laura Olalla Saad ◽  
David Grodberg ◽  
Eloisa Helena Rubello Valler Celeri

2014 ◽  
Vol 59 (6) ◽  
pp. 456-460
Author(s):  
Matthias Domhardt ◽  
Daniela Hagmann ◽  
Paul L. Plener

2013 ◽  
Vol 28 (S2) ◽  
pp. 68-68
Author(s):  
S. Cussot Charpentier ◽  
T. Maffre ◽  
J.P. Raynaud ◽  
D. Grodberg

Les troubles du spectre autistique (TSA) concernent 1 nouveau-né sur 150. Le retard au diagnostic est parfois de plusieurs années. L’Autism Mental Status Examination (AMSE) propose, par sa simplicité de passation, une aide au diagnostic pour les médecins confrontés aux troubles du spectre autistique. L’étude préliminaire consiste à déterminer le score seuil de positivité en langue française de l’échelle pour une sensibilité de l’AMSE supérieure à 80 % et une spécificité supérieure à 90 % dans une population « à haut risque de TSA ». Les patients, âgés de 18 mois à 16 ans, sont consultants de l’Unité d’évaluation des troubles envahissants du développement (CHU de Toulouse) et bénéficient d’une évaluation standardisée pluridisciplinaire suivant les dernières recommandations pour une suspicion de TSA. Les critères d’exclusion sont : un non consentement des parents, une évaluation incomplète, un âge inférieur à 18 mois ou supérieur à 16 ans, une connaissance du dossier médical du patient par l’examinateur. L’AMSE comporte 8 items évaluant le fonctionnement social, la communication et le comportement d’enfants à partir de 18 mois, renseignés grâce à l’observation clinique de l’enfant et à un entretien familial. Cette étude diagnostique, prospective, non randomisée est une étude d’équivalence : le résultat du gold standard (Autism Diagnostic Interview et Autism Diagnostic Observation Schedule) est confronté à celui de l’AMSE. L’étude est ouverte, monocentrique et prévoit l’inclusion de 40 patients sur une durée de 12 à 18 mois. Le traitement statistique utilise des courbes ROC pour déterminer le score seuil de l’AMSE pour un objectif de sensibilité supérieur à 90 % et de spécificité supérieur à 80 %, un alpha Cronbach pour tester la cohérence interne. Le projet vise à raccourcir le délai diagnostique pour une prise en charge la plus précoce possible, primordiale dans le pronostic.


2015 ◽  
Vol 45 (4) ◽  
pp. 386-398 ◽  
Author(s):  
Elysse B. Arnold ◽  
Flora Howie ◽  
Amanda Collier ◽  
Danielle Ung ◽  
Joshua Nadeau ◽  
...  

2016 ◽  
Vol 24 (7) ◽  
pp. 1078-1084 ◽  
Author(s):  
Roald A. Øien ◽  
Paige Siper ◽  
Alexander Kolevzon ◽  
David Grodberg

Objective: The social disability associated with ADHD often makes diagnostic and treatment decision making challenging. This protocol investigates the test performance of the Autism Mental Status Exam (AMSE) in detecting autism spectrum disorder (ASD) in a sample of 45 children with ADHD and ASD symptomatology. The AMSE is a brief ASD diagnostic assessment administered in the context of a clinical exam. Method: All participants received a developmental evaluation, including the AMSE, followed by independent gold standard diagnostic assessments including the Autism Diagnostic Observation Schedule (ADOS) and the Autism Diagnostic Interview–Revised (ADI-R). Results: Receiver operating characteristics (ROC) curve analysis indicated strong sensitivity and specificity in this population. Optimal cutoff scores are provided. Conclusion: The AMSE holds promise as a brief ASD assessment tool for children with ADHD and ASD symptomatology and as a guide for treatment and referral decisions at the point of care.


1988 ◽  
Vol 33 (2) ◽  
pp. 108-111 ◽  
Author(s):  
Colin A. Ross ◽  
Pierre Leichner

Twenty-six residents watched a videotape of the mental status examination of a psychotic patient, then wrote their assessment of the patient's mental status. The residents’ reports were independently graded by the authors. The residents’ marks were compared to performance on departmental oral examinations. Results showed that global or qualitative assessment of mental status performance was reliable. Excellent inter-rater reliability was achieved when the assessment criteria for sub-items of the mental status were well defined.


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