P-16 - Dexamethasone suppression test and depressive symptoms among alcohol dependent subjects are connected with positive family history of alcoholism

2012 ◽  
Vol 27 ◽  
pp. 1
Author(s):  
J.K. Brykalski
Keyword(s):  
Depressive Symptoms ◽  
Family History ◽  
Positive Family History ◽  
Dexamethasone Suppression Test ◽  
History Of ◽  
P 16 ◽  
Suppression Test ◽  
Dexamethasone Suppression ◽  
Alcohol Dependent

Pre-Pubertal Depressive Stupor: A Case Report

1988 ◽  
Vol 153 (5) ◽  
pp. 689-692 ◽  
Author(s):  
J. C. Powell ◽  
W. R. Silveira ◽  
R. Lindsay
Keyword(s):  
Case Report ◽  
Family History ◽  
Affective Disorder ◽  
Dexamethasone Suppression Test ◽  
Clinical State ◽  
Affective Illness ◽  
History Of ◽  
Suppression Test ◽  
Dexamethasone Suppression ◽  
Maternal Side

A case of childhood affective disorder with episodes of depressive stupor in a 13-year-old pre-pubertal boy is described. Changes in the patient's clinical state were accompanied by changes in the dexamethasone suppression test. A family history of affective illness on the maternal side, with phenomenological similarities, is noted.

scholarly journals Are Dexamethasone Suppression Test Nonsuppression and Thyroid Dysfunction Related to a Family History of Dementia in Patients with Major Depression? An Exploratory Study

2005 ◽  
Vol 50 (6) ◽  
pp. 342-345 ◽  
Author(s):  
Konstantinos N Fountoulakis ◽  
Stergios G Kaprinis ◽  
Apostolos Iacovides ◽  
Konstantinos Phokas ◽  
George Kaprinis
Keyword(s):  
Family History ◽  
Major Depression ◽  
Serum Levels ◽  
Thyroid Stimulating Hormone ◽  
Dexamethasone Suppression Test ◽  
Analysis Of Covariance ◽  
Free T4 ◽  
History Of ◽  
Suppression Test ◽  
Dexamethasone Suppression

Objective: Recent data suggest that the low thyroid function syndrome in depression is nonspecific, They also suggest that depression may constitute a risk factor for the development of dementia, especially in atypical patients who have high rates of hypothalamo–pituitary–adrenal axis disorders. This study aimed to search for correlations among Dexamethasone Suppression Test (DST) cortisol levels, thyroid indices, and family history of dementia in patients with depression. Methods: A sample of 30 patients, aged 21 to 60 years and suffering from major depression according to DSM-IV criteria, took part in the study. Three had a family history of dementia in first-degree relatives. We measured their serum levels of free T3, free T4, thyroid-stimulating hormone, thyroid binding inhibitory immunoglobulines, thyroglobulin antibodies, and thyroid microsomal antibodies (TMAs). We applied the 1-mg DST to all patients. The statistical analysis included 1-way multivariate analysis of covariance using t tests as the post hoc tests. Results: Significantly higher levels of TMAs were found in patients with a family history of dementia, compared with those who did not have this family history. Conclusion: The results of this study suggest that a more pronounced autoimmune process may characterize depression patients with a family history of dementia.

Biochemically silent phaeochromocytoma presenting with non-specific loin pain

2021 ◽  
Vol 14 (8) ◽  
pp. e244258
Author(s):  
Annalisa Montebello ◽  
Etienne Ceci Bonello ◽  
Miriam Giordano Imbroll ◽  
Mark Gruppetta
Keyword(s):  
Adrenal Adenoma ◽  
Dexamethasone Suppression Test ◽  
Adrenal Lesion ◽  
Genetic Mutations ◽  
Large Size ◽  
History Of ◽  
Loin Pain ◽  
Suppression Test ◽  
Aldosterone To Renin Ratio ◽  
Dexamethasone Suppression

A 55-year-old woman presented with a 4-month history of right-sided non-specific loin pain and 6 kg weight loss. A CT scan of the abdomen and pelvis showed an incidental 4.5 cm right-sided adrenal lesion which was not typical of an adrenal adenoma. This was further confirmed on MRI of the adrenals. Biochemical investigations to investigate for a functional adrenal lesion included serum catecholamines and metanephrines, an aldosterone to renin ratio and an overnight dexamethasone suppression test. These were all negative. A laparoscopic adrenalectomy was performed in view of the large size of the lesion. Histology was consistent with a phaeochromocytoma, which confirmed the diagnosis of a non-secreting phaeochromocytoma. Non-secreting phaeochromocytomas are rare and usually found in patients with known genetic mutations. Adrenal lesions not related to any mutations similar to our case are even rarer and reported even less in the literature.

Depressive symptoms and the dexamethasone suppression test in parkinsonian patients

1987 ◽  
Vol 22 (3) ◽  
pp. 386-389 ◽  
Author(s):  
M.Luiz Frochtengarten ◽  
João C.B. Villares ◽  
Eliana Maluf ◽  
E.A. Carlini
Keyword(s):  
Depressive Symptoms ◽  
Dexamethasone Suppression Test ◽  
Suppression Test ◽  
Dexamethasone Suppression

Dexamethasone suppression test and suicide attempts in schizophrenic patients

2001 ◽  
Vol 16 (7) ◽  
pp. 428-431 ◽  
Author(s):  
M. Płocka-Lewandowska ◽  
A. Araszkiewicz ◽  
J.K. Rybakowski
Keyword(s):  
Suicide Attempt ◽  
Suicide Attempts ◽  
Dexamethasone Suppression Test ◽  
Course Of Illness ◽  
Future Attempt ◽  
Schizophrenic Patients ◽  
History Of ◽  
Suppression Test ◽  
Cortisol Levels ◽  
Dexamethasone Suppression

SummaryThe suicide attempts were assessed in 32 schizophrenic patients on whom the dexamethasone suppression test (DST) was done twice in the course of illness: in the years 1985–91 and 1996–97. In the 1985–91 period, both baseline and post-dexamethasone cortisol levels were significantly higher in the patients with previous suicide attempts and baseline cortisol was higher in the patients who were to make a future attempt. In 1996–97, DST non-suppression was shown in more than half of the patients with a history of suicide attempt and in none of those without such history: all cortisol levels were significantly higher in the patients with a history of suicide attempt. Although the mean intensity of depression was higher in the patients with a history of suicide attempt, no association between the intensity of depression and present or previous DST non-suppression status was found. It is suggested that the hyperactivity of the hypothalamic-pituitary-adrenal axis may constitute an element of diathesis for suicidal behavior in schizophrenic patients.

Depression, Weight Loss and the Dexamethasone Suppression Test

1984 ◽  
Vol 145 (1) ◽  
pp. 88-90 ◽  
Author(s):  
Alec Coppen ◽  
Janet Harwood ◽  
Keith Wood
Keyword(s):  
Weight Loss ◽  
Major Depressive Disorder ◽  
Depressive Illness ◽  
Dexamethasone Suppression Test ◽  
Necessary Condition ◽  
Major Depressive ◽  
Significant Difference ◽  
History Of ◽  
Suppression Test ◽  
Dexamethasone Suppression

SummaryThe dexamethasone suppression test (DST) was carried out on 143 patients with a major depressive disorder, who were classified into those with a history of weight loss (n = 89) and those without (n = 54). Seventy-three per cent of patients with weight loss and 61% of patients without had an abnormal DST; this difference was not statistically significant. Of the patients receiving prophylactic lithium therapy, 13 were found to have changed their DST status on retesting after a period of 14 months, but there was no significant difference in their weight. It is concluded that weight loss is not a necessary condition for an abnormal DST in depressive illness.

scholarly journals Co-Occurrence of Exogenous and Endogenous Cushing’s Syndromes—Dilemma in Diagnosis

2019 ◽  
Vol 2019 ◽  
pp. 1-3
Author(s):  
Chin Voon Tong ◽  
Subashini Rajoo
Keyword(s):  
Cushing’S Syndrome ◽  
Adrenal Adenoma ◽  
Cushing's Syndrome ◽  
Dexamethasone Suppression Test ◽  
Adrenal Cortical Adenoma ◽  
Thin Skin ◽  
History Of ◽  
Musculoskeletal Manifestations ◽  
Suppression Test ◽  
Dexamethasone Suppression

Approach to patients who manifest with features of Cushing’s syndrome often begin with exclusion of exposure to excessive exogenous source of glucocorticoids (GC). Most guidelines advocate no further assessment if excessive exogenous GC use is present. We present a case of a 66-year-old lady who was noted to have typical features of Cushing’s syndrome. As she gave a very clear history of ingesting exogenous GC for a year, no further work up was undertaken. Despite cessation of GC for a year, she continued to have thin skin and easy bruising. Upon admission for hypertensive emergency, her clinician took note of her changes and investigated her for endogenous Cushing’s syndrome. Her cortisol post overnight dexamethasone suppression test was 707 nmol/l. Post low dose dexamethasone suppression test yielded a cortisol of 1133.2 nmol/l. 24 hours urine cortisol was 432.2 nmol/l. Plasma ACTH was 1.1 pmol/l, indicating an ACTH independent Cushing’s syndrome. We proceeded with Computed tomography scan (CT scan) of adrenals which revealed a right adrenal adenoma measuring 4.4 × 3.4 × 4.0 cm. Right retroperiteneoscopic adrenalectomy was done. Histopathology examination was consistent with adrenal cortical adenoma with foci of myelolipoma. Post adrenalectomy she developed hypocortisolism secondary to contralateral adrenal suppression which lasted up to the present date. Her cutaneous and musculoskeletal manifestations improved substantially. Co-occurrence of endogenous and exogenous Cushing’s syndromes is uncommon but should be considered in patients whose Cushingnoid features do not resolve after cessation of exogenous GC.

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