P.4.c.007 Effect of escitalopram treatment on the relationship of pre- to postsynaptic serotonin-1A receptors in anxiety disorders

2009 ◽  
Vol 19 ◽  
pp. S607-S608
Author(s):  
A. Hahn ◽  
R. Lanzenberger ◽  
M. Fink ◽  
P. Stein ◽  
L.K. Mien ◽  
...  
Twin Research ◽  
2000 ◽  
Vol 3 (1) ◽  
pp. 28-32 ◽  
Author(s):  
Michael J Lyons ◽  
Jonathan Huppert ◽  
Rosemary Toomey ◽  
Rebecca Harley ◽  
Jack Goldberg ◽  
...  

AbstractThere have been long questions about the relationship of schizophrenia to other mental disorders. Lifetime DSM-III-R diagnoses of mood and anxiety disorders in twins with clinically diagnosed schizophrenia (n = 24) and their non-affected co-twins (n = 24) were compared with twins from pairs without schizophrenia (n = 3327) using a sample from the Vietnam Era Twin Registry. Schizophrenic probands had significantly elevated rates of all included disorders (bipolar disorder, major depression, dysthymia, generalized anxiety disorder, panic disorder, and PTSD) compared with controls (P < 0.01). The odd ratios comparing co-twins of schizophrenic probands with controls was greater than three for every disorder, but did not attain statistical significance. A similar pattern was observed when analyses were restricted to only monozygotic twins (n = 12). Consistent with other studies, schizophrenics appeared to have higher rates of a range of mental disorders. Our results suggest that schizophrenia per se represents a risk factor for other psychiatric disorders, but the absence of significantly elevated risk among non-schizophrenic co-twins suggested that family environmental and/or genetic factors that contribute to risk of schizophrenia do not increase the risk of mood and anxiety disorders to the same extent that the risk of these other disorders is increased by the presence of schizophrenia. Twin Research (2000) 3, 28–32.


2021 ◽  
Vol LII (3) ◽  
pp. 35-40
Author(s):  
Valentin N. Pavlov ◽  
Denis A. Karpov ◽  
Shamil M. Safin ◽  
Vladimir L. Yuldashev

The aim of this study is to analyze the occurrence of depressive and anxiety disorders in patients with COVID-19 and to study the relationship of these disorders with organic damage to the central nervous system. Material and methods. An analysis of occurrence of depressive and anxiety disorders in patients with COVID-19 was carried out at the infectious hospital of the KBGMU for the period June-August 2020. Depression and anxiety were identified using the Hospital Anxiety and Depression Scale (HADS) and compared with the MRI data of the brain. Statistical data processing was carried out using Microsoft Excel 7.0. Results. According to the analysis, out of 76 patients with COVID-19, depressive disorders were observed in 36 (46.3%) patients, anxiety disorders subclinical anxiety in 16 (21.05%), clinical anxiety in 19 (25%). The absence of depressive disorders was observed in 40 (52.63%), the absence of anxiety in 41 (53.94%). By gender differentiation of patients, depressive disorders in men 20 (46.5%), women 16 (48.48%). Anxiety disorders: subclinical anxiety in men 11 (25.5%), women 5 (15.15 %), clinical anxiety in men 7 (16.2%), women 12 (36.36%). The average age of patients at the time of the study was 45.7 years. When conducting MRI of brain, organic lesions were detected in 12 (16%) people, in 64 (84%) at the time of the study, organic lesions were not detected. When collecting a follow-up in 31 patients, depressive disorders were noted in 8 (25.8%), subclinical anxiety 2 (6.45%), clinical anxiety 2 (6.45%), no anxiety 27 (87.09%), no depression 23 (74.19%). No organic lesions were found at the time of MRI of brain. Conclusion. When studying the occurrence of depressive and anxious states and their organic substrates, we found that there is no clear relationship between them and rather have a functional character.


2004 ◽  
Vol 66 (3) ◽  
pp. 349-355 ◽  
Author(s):  
Wayne J. Katon ◽  
Laura Richardson ◽  
Paula Lozano ◽  
Elizabeth McCauley

2014 ◽  
Author(s):  
Jose Gonzalez ◽  
Samantha Russell ◽  
Brooke Edwards ◽  
Cassie Padilla ◽  
Aned Bosques ◽  
...  

1992 ◽  
Vol 4 (2) ◽  
pp. 25-30 ◽  
Author(s):  
H.J.G.M. van Megen ◽  
J.A. den Boer ◽  
H.G.M. Westenberg

SummaryIn this review article four neuropeptides: adrenocorticotrope hormone (ACTH), corticotrope releasing hormone (CRH), neuropeptide- Y(NPY) and cholecystokinin (CCK) are discussed with respect to their possible role in the pathogenesis of anxiety disorders. First the presumable working mechanism of these peptides in the brain is mentioned. In addition, the relationship of these peptides and anxiety is outlined using neuroanatomical and electrophysiological research data. Subsequently, animal experiments and human research findings are discussed. Most of the research findings so far are obtained from animal data. Only with respect to CCK, there is increasing evidence, also from human studies, that this peptide might play a role in the pathogenesis of anxiety disorders. The putative role of the other peptides remains to be estab lished in future research.


2006 ◽  
Vol 194 (12) ◽  
pp. 951-957 ◽  
Author(s):  
Naomi M. Simon ◽  
Alexander M. Weiss ◽  
Richard Kradin ◽  
Karleyton C. Evans ◽  
Hannah E. Reese ◽  
...  

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