Resistance of low density lipoprotein subfractions to oxidation in diabetic patients with combined hyperlipidemia

ABSTRACT Aims: Previous studies have shown that diabetes mellitus (DM) increases the risk of cardiovascular diseases in females to a greater extent than in males. In this cross-sectional study, we evaluated the lipid profiles of type 2 diabetic males and females. Materials and Methods: The study included 107 type 2 diabetic patients (41 males and 66 females), and 122 hypertensive type 2 diabetic patients (39 males and 83 females), aged 15 years and older. Total cholesterol (TC), triglycerides (TG), low density lipoprotein-cholesterol (LDL-C), very low density lipoprotein-cholesterol (VLDL-C) and high density lipoprotein-cholesterol (HDL-C) concentrations were assayed for each group using standard biochemical methods. Results: The mean TC, TG, VLDL-C, HDL-C and LDL-C concentrations, TG/HDL and LDL/HDL ratios were higher in type 2 diabetic and hypertensive type 2 diabetic patients compared with non-diabetic, and hypertensive non-diabetic control subjects, although these were not significant (P > 0.05). Hypertensive type 2 diabetic females had significantly higher serum TC (7.42 ± 1.63 mmol/L) than hypertensive non-diabetic males (5.76±1.57 mmol/L; P < 0.05). All the other lipid and lipoprotein parameters except HDL-C were non-significantly higher in females with type 2 DM and those with hypertension and type 2 DM, compared with type 2 diabetic and hypertensive type 2 diabetic males, respectively (P > 0.05). Conclusion: This study demonstrated that dyslipidemia exists in our type 2 diabetic population with greater TC in hypertensive type 2 diabetic females compared with hypertensive type 2 diabetic males. This suggests that hypertensive type 2 diabetic females are exposed more profoundly to risk factors including atherogenic dyslipidemia compared with males.

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Validity of a Novel Method for Estimation of Low-Density Lipoprotein Cholesterol Levels in Diabetic Patients

Journal of Atherosclerosis and Thrombosis ◽

10.5551/jat.35972 ◽

2016 ◽

Vol 23 (12) ◽

pp. 1355-1364 ◽

Cited By ~ 13

Author(s):

Hideto Chaen ◽

Shigesumi Kinchiku ◽

Masaaki Miyata ◽

Shoko Kajiya ◽

Hitoshi Uenomachi ◽

...

Keyword(s):

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Lipoprotein Cholesterol ◽

Diabetic Patients ◽

Low Density ◽

Low Density Lipoprotein Cholesterol ◽

Cholesterol Levels ◽

Novel Method

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Evaluation of type-2 diabetes mellitus patients for dyslipidemia in a tertiary care centre

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20201078 ◽

2020 ◽

Vol 7 (4) ◽

pp. 586

Author(s):

Janak G. Chokshi ◽

Apal P. Gandhi ◽

Ishvarlal M. Parmar ◽

Dipen R. Damor

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Total Cholesterol ◽

Plasma Glucose ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Diabetic Patients ◽

Low Density ◽

Increased Risk

Background: Diabetes mellitus (DM) is a syndrome consisting of metabolic, vascular and neuropathic components that are interrelated. Diabetes mellitus is associated with a considerably increased risk of premature atherosclerosis, particularly coronary heart disease (CHD) and peripheral arterial disease. Dyslipidemia is a common feature of diabetes. There is an association between atherosclerotic cardiovascular disease and serum cholesterol and triglyceride levels in both type 1 and type 2 diabetes.Methods: The study was done on 50 adult diabetes mellitus (T2) patients from IPD of General Medicine wards at SMS Hospital, Ahmedabad, Gujarat. 50 healthy age and sex matched healthy volunteers were taken as control. They were evaluated for lipid profile i.e., Total Cholesterol (TC),Triglyceride (TG), Low-density lipoprotein (LDL), High density lipoprotein (HDL), Very low density lipoprotein (VLDL) and glycemic status i.e., Fasting blood glucose (FBS), Postprandial 2 hours blood glucose (PP2BS) & Glycosylated haemoglobin(HbA1C).Results: Diabetic cases had statistically highly significant (p<0.001) elevated levels of total Cholesterol, Triglycerides and VLDL as compared to controls. Serum TG, serum TC, LDL-C and VLDL-C had positive correlation with the postprandial plasma glucose, fasting plasma glucose and HbA1c.Conclusions: Significant correlations between HbA1c levels and lipid levels point towards the usefulness of HbA1c for screening high-risk diabetic patients. High TC, TG, LDL-C and HbA1c with normal or low HDL-C is seen in almost all diabetic patients either alone or in combinations.

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The effect of rosuvastatin on low-density lipoprotein subfractions in patients with impaired fasting glucose

Atherosclerosis ◽

10.1016/j.atherosclerosis.2014.05.760 ◽

2014 ◽

Vol 235 (2) ◽

pp. e254

Author(s):

C.V. Rizos ◽

M.S. Kostapanos ◽

E.C. Rizos ◽

A.D. Tselepis ◽

M.S. Elisaf

Keyword(s):

Impaired Fasting Glucose ◽

Fasting Glucose ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Low Density ◽

Lipoprotein Subfractions

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Abnormal composition of apoproteins C-I, C-II, and C-III in plasma and very-low-density lipoproteins of non-insulin-dependent diabetic Chinese.

Clinical Chemistry ◽

10.1093/clinchem/32.10.1914 ◽

1986 ◽

Vol 32 (10) ◽

pp. 1914-1920 ◽

Cited By ~ 7

Author(s):

X R Pan ◽

M C Cheung ◽

C E Walden ◽

S X Hu ◽

E L Bierman ◽

...

Keyword(s):

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Diabetic Patients ◽

Low Density ◽

Strongly Correlated ◽

Very Low Density Lipoproteins ◽

White American ◽

Insulin Dependent ◽

L Value ◽

Insulin Dependent Diabetic

Abstract Apoprotein (apo) C-I, C-II, and C-III were measured in plasma from 35 white American non-diabetic subjects. The mean concentrations (mg/L) in plasma from normolipidemic and hypertriglyceridemic subjects, respectively, were apo C-I, 78 and 311; apo C-II, 37 and 200; and apo C-III, 98 and 529. These concentrations were strongly correlated with the concentrations of plasma triglyceride (TG). We also measured these apoproteins in 23 Chinese non-insulin-dependent diabetic patients (13 men, 10 women) and in eight male and 10 female non-diabetic Chinese controls. The male diabetics had significantly lower concentrations of apo C-I in plasma, and lower apo C-I/TG, apo C-II/TG, apo C-III/TG, and apo C-I/C-III ratios than did the controls. The female diabetics had significantly higher apo C-II concentrations than the controls. The median value for plasma glucose during fasting was 1400 mg/L in the male diabetic subjects, similar to the 1370 mg/L value in female diabetics. Therefore, the higher concentrations of very-low-density lipoprotein in male diabetics may not reflect hyperglycemia per se.

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