Synthesis of N-Boc-(R)-α-phenyl-γ-aminobutyric acid using an in situ diastereoselective protonation strategy

2002 ◽  
Vol 13 (3) ◽  
pp. 293-296 ◽  
Author(s):  
Monique Calmès ◽  
Françoise Escale ◽  
Jean Martinez
Keyword(s):  
Aminobutyric Acid

gamma-Aminobutyric acid concentrations are maintained in anoxic turtle brain

1985 ◽  
Vol 249 (3) ◽  
pp. R372-R374 ◽  
Author(s):  
P. L. Lutz ◽  
R. Edwards ◽  
P. M. McMahon
Keyword(s):  
Initial Period ◽  
Aminobutyric Acid ◽  
Gamma Aminobutyric Acid ◽  
Pseudemys Scripta

Changes in gamma-aminobutyric acid (GABA) concentrations in the turtle (Pseudemys scripta elegans) brain were studied in situ during prolonged anoxia. With the onset of anoxia, the well-documented rapid increases in GABA found in mammalian brains were not observed in the turtle brain. Although not statistically significant, mean GABA concentrations in the turtle brain were reduced from anesthetized control values during the first 30 min of anoxia. During this initial period brain glutamate content declined. Even after 2 h of nitrogen respiration, GABA in the turtle brain still did not rise above control levels. By the 4th h of anoxia, however, GABA had increased to 147% of control values.

In situ production of γ-aminobutyric acid in breakfast cereals

2011 ◽  
Vol 129 (2) ◽  
pp. 395-401 ◽  
Author(s):  
Iris J. Joye ◽  
Lieve Lamberts ◽  
Kristof Brijs ◽  
Jan A. Delcour
Keyword(s):  
Aminobutyric Acid ◽  
Breakfast Cereals ◽  
In Situ Production

Ring Size Influence on the Cyclocondensation Mode of GABA – Nitrile Imine Adducts

2004 ◽  
Vol 59 (8) ◽  
pp. 930-933 ◽  
Author(s):  
Bassam A. Abu Thaher ◽  
Jalal A. Zahra ◽  
Mustafa M. El-Abadelah ◽  
W. Voelter
Keyword(s):  
Aminobutyric Acid ◽  
Ring Size ◽  
Nitrile Imine ◽  
Nmr Data

Abstractγ -Aminobutyric acid (GABA) adds onto nitrile imine 1,3-dipolar species (generated in situ from their N-arylhydrazonoyl chloride precursors 1a-c ) to deliver the corresponding acyclic amidrazone adducts 10a-c. In the presence of 1,1’-carbonyldiimidazole, the latter adducts undergo cyclocondensation involving the activated carboxyl and the amidrazone-CH2NH groups to afford the respective N-[1-(arylhydrazono)-2-oxopropan-1-yl] pyrrolidin-2-ones (11a-c). The constitution of 10 and 11 is evidenced from analytical and spectral (IR , MS and NMR) data.

Synapsin I Synchronizes GABA Release in Distinct Interneuron Subpopulations

2019 ◽  
Vol 30 (3) ◽  
pp. 1393-1406
Author(s):  
N Forte ◽  
F Binda ◽  
A Contestabile ◽  
F Benfenati ◽  
P Baldelli
Keyword(s):  
In Situ Hybridization ◽  
Patch Clamp ◽  
Action Potential ◽  
Hippocampal Slices ◽  
Gaba Release ◽  
Aminobutyric Acid ◽  
Synapsin I ◽  
Gamma Aminobutyric Acid ◽  
Asynchronous Release

Abstract Neurotransmitters can be released either synchronously or asynchronously with respect to action potential timing. Synapsins (Syns) are a family of synaptic vesicle (SV) phosphoproteins that assist gamma-aminobutyric acid (GABA) release and allow a physiological excitation/inhibition balance. Consistently, deletion of either or both Syn1 and Syn2 genes is epileptogenic. In this work, we have characterized the effect of SynI knockout (KO) in the regulation of GABA release dynamics. Using patch-clamp recordings in hippocampal slices, we demonstrate that the lack of SynI impairs synchronous GABA release via a reduction of the readily releasable SVs and, in parallel, increases asynchronous GABA release. The effects of SynI deletion on synchronous GABA release were occluded by ω-AgatoxinIVA, indicating the involvement of P/Q-type Ca2+channel-expressing neurons. Using in situ hybridization, we show that SynI is more expressed in parvalbumin (PV) interneurons, characterized by synchronous release, than in cholecystokinin or SOM interneurons, characterized by a more asynchronous release. Optogenetic activation of PV and SOM interneurons revealed a specific reduction of synchronous release in PV/SynIKO interneurons associated with an increased asynchronous release in SOM/SynIKO interneurons. The results demonstrate that SynI is differentially expressed in interneuron subpopulations, where it boosts synchronous and limits asynchronous GABA release.

Regulation of Γ -aminobutyric acid synthesis in situ by glutamate availability

1999 ◽  
Vol 106 (4) ◽  
pp. 363-369 ◽  
Author(s):  
Catherine P. Scott-Taggart ◽  
Owen R. Van Cauwenberghe ◽  
Michael D. McLean ◽  
Barry J. Shelp
Keyword(s):  
Acid Synthesis ◽  
Aminobutyric Acid
Sign in / Sign up

Export Citation Format

Share Document