Expression of uracil DNA glycosylase (UDG) does not affect cellular sensitivity to thymidylate synthase (TS) inhibition

2003 ◽  
Vol 39 (3) ◽  
pp. 378-387 ◽  
Author(s):  
S.J Welsh ◽  
S Hobbs ◽  
G.W Aherne
Keyword(s):  
Thymidylate Synthase ◽  
Dna Glycosylase ◽  
Uracil Dna Glycosylase ◽  
Cellular Sensitivity

scholarly journals A possible link to uracil DNA glycosylase in the synergistic action of HDAC inhibitors and thymidylate synthase inhibitors

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Meredith S. Showler ◽  
Brian P. Weiser
Keyword(s):  
Cell Lines ◽  
Thymidylate Synthase ◽  
Recent Article ◽  
Hdac Inhibitors ◽  
Synergistic Action ◽  
Dna Glycosylase ◽  
Uracil Dna Glycosylase ◽  
Cellular Toxicity ◽  
Cancer Types ◽  
Thymidylate Synthase Inhibitors

Abstract It is well established that thymidylate synthase inhibitors can cause cellular toxicity through uracil DNA glycosylase (UNG2)-dependent pathways. Additionally, thymidylate synthase inhibitors and HDAC inhibitors are known to act synergistically in a variety of cancer types. A recent article from J. Transl. Med. links these together by demonstrating widespread depletion of UNG2 levels across a variety of cell lines treated with HDAC inhibitors. Recent findings suggest that UNG2 depletion by HDAC inhibitors would likely be an effective method to sensitize cells to thymidylate synthase inhibitors. This is particularly important for cancer types that are typically resistant to thymidylate synthase inhibitors, such as cells that are deficient in p53 activity.

scholarly journals Use of a molecular beacon based fluorescent method for assaying uracil DNA glycosylase (Ung) activity and inhibitor screening

2021 ◽  
Vol 26 ◽  
pp. 100954
Author(s):  
Avani Mehta ◽  
Prateek Raj ◽  
Sandeep Sundriyal ◽  
Balasubramanian Gopal ◽  
Umesh Varshney
Keyword(s):  
Molecular Beacon ◽  
Dna Glycosylase ◽  
Uracil Dna Glycosylase ◽  
Inhibitor Screening ◽  
Fluorescent Method

Crystal Structure of Family 5 Uracil-DNA Glycosylase Bound to DNA

2007 ◽  
Vol 373 (4) ◽  
pp. 839-850 ◽  
Author(s):  
Hiromichi Kosaka ◽  
Jun Hoseki ◽  
Noriko Nakagawa ◽  
Seiki Kuramitsu ◽  
Ryoji Masui
Keyword(s):  
Crystal Structure ◽  
Dna Glycosylase ◽  
Uracil Dna Glycosylase

Uracil-DNA Glycosylase Produces Excess Lethal Damage Induced by an Auger Cascade in BrdU-labelled Bacteriophage T1

1993 ◽  
Vol 64 (2) ◽  
pp. 157-164 ◽  
Author(s):  
Y. Furusawa ◽  
H. Maezawa ◽  
K. Suzuki ◽  
Y. Yamamoto ◽  
K. Kobayashi ◽  
...  
Keyword(s):  
Dna Glycosylase ◽  
Uracil Dna Glycosylase ◽  
Lethal Damage
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