Abstract 3854: Inhibition of uracil DNA glycosylase (UDG) sensitizes cancer cells to thymidylate synthase inhibitors

2015 ◽  
Author(s):  
Yan Yan ◽  
Allison Condie ◽  
Stanton Gerson
Keyword(s):  
Cancer Cells ◽  
Thymidylate Synthase ◽  
Dna Glycosylase ◽  
Uracil Dna Glycosylase ◽  
Thymidylate Synthase Inhibitors

scholarly journals A possible link to uracil DNA glycosylase in the synergistic action of HDAC inhibitors and thymidylate synthase inhibitors

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Meredith S. Showler ◽  
Brian P. Weiser
Keyword(s):  
Cell Lines ◽  
Thymidylate Synthase ◽  
Recent Article ◽  
Hdac Inhibitors ◽  
Synergistic Action ◽  
Dna Glycosylase ◽  
Uracil Dna Glycosylase ◽  
Cellular Toxicity ◽  
Cancer Types ◽  
Thymidylate Synthase Inhibitors

Abstract It is well established that thymidylate synthase inhibitors can cause cellular toxicity through uracil DNA glycosylase (UNG2)-dependent pathways. Additionally, thymidylate synthase inhibitors and HDAC inhibitors are known to act synergistically in a variety of cancer types. A recent article from J. Transl. Med. links these together by demonstrating widespread depletion of UNG2 levels across a variety of cell lines treated with HDAC inhibitors. Recent findings suggest that UNG2 depletion by HDAC inhibitors would likely be an effective method to sensitize cells to thymidylate synthase inhibitors. This is particularly important for cancer types that are typically resistant to thymidylate synthase inhibitors, such as cells that are deficient in p53 activity.

scholarly journals Inhibition of uracil DNA glycosylase sensitizes cancer cells to 5-fluorodeoxyuridine through replication fork collapse-induced DNA damage

Oncotarget ◽  
2016 ◽  
Vol 7 (37) ◽  
pp. 59299-59313 ◽  
Author(s):  
Yan Yan ◽  
Xiangzi Han ◽  
Yulan Qing ◽  
Allison G. Condie ◽  
Shashank Gorityala ◽  
...  
Keyword(s):  
Dna Damage ◽  
Cancer Cells ◽  
Replication Fork ◽  
Dna Glycosylase ◽  
Uracil Dna Glycosylase

Label-free and high-throughput bioluminescence detection of uracil-DNA glycosylase in cancer cells through tricyclic cascade signal amplification

2018 ◽  
Vol 54 (51) ◽  
pp. 6991-6994 ◽  
Author(s):  
Yan Zhang ◽  
Qing-nan Li ◽  
Chen-chen Li ◽  
Chun-yang Zhang
Keyword(s):  
Cancer Cells ◽  
High Throughput ◽  
Signal Amplification ◽  
Sensitive Detection ◽  
Dna Glycosylase ◽  
Label Free ◽  
Uracil Dna Glycosylase ◽  
Bioluminescence Method

We develop a label-free and high-throughput bioluminescence method for the sensitive detection of uracil DNA glycosylase through tricyclic cascade signal amplification.

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