6004 ORAL Role of Baseline Circulating Tumour Cells and KRas Status in Patients With Metastatic Colorectal Cancer Treated With First-line Chemotherapy Plus Bevacizumab: a TTD Spanish Group Cooperative Study

2011 ◽  
Vol 47 ◽  
pp. S392 ◽  
Author(s):  
J. Sastre ◽  
M. Vidaurreta ◽  
A. Gomez ◽  
F. Rivera ◽  
M. Valladares-Ayerbes ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Tumour Cells ◽  
Circulating Tumour Cells ◽  
Cooperative Study ◽  
First Line ◽  
Kras Status ◽  
Line Chemotherapy

scholarly journals Role of Kras Status in Patients with Metastatic Colorectal Cancer Receiving First-Line Chemotherapy plus Bevacizumab: A TTD Group Cooperative Study

PLoS ONE ◽  
2012 ◽  
Vol 7 (10) ◽  
pp. e47345 ◽  
Author(s):  
Eduardo Díaz-Rubio ◽  
Auxiliadora Gómez-España ◽  
Bartomeu Massutí ◽  
Javier Sastre ◽  
Margarita Reboredo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Cooperative Study ◽  
First Line ◽  
Kras Status ◽  
Line Chemotherapy

scholarly journals Prognostic role of sarcopenia in metastatic colorectal cancer patients during first-line chemotherapy: A retrospective study

2021 ◽  
Vol 12 (5) ◽  
pp. 355-366
Author(s):  
Chiara Maddalena ◽  
Andrea Ponsiglione ◽  
Luigi Camera ◽  
Lidia Santarpia ◽  
Fabrizio Pasanisi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Retrospective Study ◽  
Metastatic Colorectal Cancer ◽  
Cancer Patients ◽  
Prognostic Role ◽  
First Line ◽  
Colorectal Cancer Patients ◽  
Line Chemotherapy

scholarly journals Therapeutic Targeting of the Tumour Microenvironment in Metastatic Colorectal Cancer

2021 ◽  
Vol 22 (4) ◽  
pp. 2067
Author(s):  
Rhynelle S. Dmello ◽  
Sarah Q. To ◽  
Ashwini L. Chand
Keyword(s):  
Colorectal Cancer ◽  
Targeted Therapy ◽  
Liver Metastasis ◽  
Metastatic Colorectal Cancer ◽  
Tumour Microenvironment ◽  
Tumour Cells ◽  
Cellular Interactions ◽  
Circulating Tumour Cells ◽  
Therapeutic Targeting ◽  
Colorectal Cancer Patients

Liver metastasis is the primary contributor to the death of patients with colorectal cancer. Despite the overall success of current treatments including targeted therapy, chemotherapy, and immunotherapy combinations in colorectal cancer patients, the prognosis of patients with liver metastasis remains poor. Recent studies have highlighted the importance of the tumour microenvironment and the crosstalk within that determines the fate of circulating tumour cells in distant organs. Understanding the interactions between liver resident cells and tumour cells colonising the liver opens new therapeutic windows for the successful treatment of metastatic colorectal cancer. Here we discuss critical cellular interactions within the tumour microenvironment in primary tumours and in liver metastases that highlight potential therapeutic targets. We also discuss recent therapeutic advances for the treatment of metastatic colorectal cancer.

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