Value and indications of surgery in locally advanced breast cancers

1997 ◽  
Vol 33 ◽  
pp. S216
Author(s):  
C. Nos ◽  
A. Fourquet ◽  
J.M. Cosset ◽  
B. Asselain ◽  
T. Palangie ◽  
...  
Keyword(s):  
Locally Advanced ◽  
Advanced Breast ◽  
Breast Cancers

scholarly journals Changes in allelic imbalances in locally advanced breast cancers after chemotherapy

2007 ◽  
Vol 97 (8) ◽  
pp. 1157-1164 ◽  
Author(s):  
M Varna ◽  
H Soliman ◽  
J-P Feugeas ◽  
E Turpin ◽  
D Chapelin ◽  
...  
Keyword(s):  
Locally Advanced ◽  
Advanced Breast ◽  
Breast Cancers

Treatment and Outcomes of Women With Large Locally Advanced Breast Cancer

2020 ◽  
pp. 000313482095633
Author(s):  
Christopher W. Mangieri ◽  
Julia Ruffo ◽  
Akiko Chiba ◽  
Marissa Howard-McNatt
Keyword(s):  
Breast Cancer ◽  
Metastatic Cancer ◽  
Locally Advanced Breast Cancer ◽  
Multidisciplinary Treatment ◽  
Locally Advanced ◽  
Radical Mastectomy ◽  
Advanced Breast ◽  
Breast Cancers ◽  
Social Challenges ◽  
Radiation Treatments

Advances in breast cancer research have made breast cancer a treatable disease. However, there is a population of women who present with large, advanced, or sometimes neglected breast cancers who can prove difficult to treat. These women often require multiple modality treatment including chemotherapy, surgery, and radiation. The purpose of our study is to examine the treatment and outcomes on women with large, locally advanced breast cancers (LABCs). We identified 8 individuals who presented with LABCs requiring extensive treatment. Patients with inflammatory or metastatic cancer at the time of presentation were excluded. These patients’ charts were reviewed and analyzed. Patient demographics, hormone receptor status, stage, types of treatment, presence of metastasis, survival, and presence of barriers for seeking treatment sooner were identified. The median age at presentation was 65 years old. The patients were equally African American and Caucasian. All patients presented with T4 or stage 3 tumors involving the skin and/or pectoralis muscle. Half of the patients were found to have triple-negative (estrogen receptor, progesterone receptor, Her-2/neu negative) tumors. 87% of the patients received chemotherapy; 1 refused. All 8 patients, either neoadjuvantly or adjuvantly, underwent a modified radical or radical mastectomy. Skin graft or flap coverage was necessary in half of the patients. Postmastectomy radiation was received in 87% of the patients; 1 patient refused the treatment. Half of the patients developed metastatic disease. Thirty-seven percent of the patients have since died with a median survival of 44 months. Reasons for delay in seeking care were monetary or social barriers. Many of the patients finally sought care via the emergency room due to symptoms they could no longer ignore. Women who present with LABC require complex multidisciplinary treatment consisting of chemotherapy, surgery, and radiation treatments. Many of these patients faced economic and social challenges to accessing care. Better access to care and more prompt connection to breast surgeons are required to assist this patient population.

Hypermethylation analysis of mismatch repair genes (hmlh1 and hmsh2) in locally advanced breast cancers in Indian women

2008 ◽  
Vol 39 (5) ◽  
pp. 672-680 ◽  
Author(s):  
Raza Ali Naqvi ◽  
Arif Hussain ◽  
Suryanarayan S.V. Deo ◽  
Himani Kukreti ◽  
Madhur Chauhan ◽  
...  
Keyword(s):  
Mismatch Repair ◽  
Locally Advanced ◽  
Advanced Breast ◽  
Mismatch Repair Genes ◽  
Breast Cancers ◽  
Indian Women ◽  
Repair Genes

Disease-free survival pattern in breast cancer patients in India treated in a single institution.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e12030-e12030 ◽  
Author(s):  
Basavalinga S. Ajaikumar ◽  
Kodaganur Srinivasachar Gopinath ◽  
B S Srinath ◽  
Ramesh Bilimagga S ◽  
Nalini K Rao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Locally Advanced ◽  
Disease Free Survival ◽  
Advanced Breast ◽  
Breast Cancers ◽  
Breast Cancer Patients ◽  
Free Survival ◽  
Distant Failure ◽  
Her 2 ◽  
Disease Free

e12030 Background: This study elucidates data from a 5 year retrospective study evaluating survival rates and prognostic factors in breast carcinoma patients in a private cancer set up in south India. Methods: 1046 patients who were treated between years 2003 to 2008 were analyzed. Clinical data including stage, histopathology type, age, node positivity, treatment plan, chemotherapy regimen, ER/ PR and Her2 Neu status, type of surgery etc were abstracted in a database. Five year disease free survival, local failure free survival and distant failure free survival was calculated using Kaplan Meier survival curves. Log rank mantel hazel tests were used to compare two survival curves. Results: Local recurrence was seen in 4% and distant metastases in 22% of the study sample. 62% of patients presented with early breast cancer (AJCC Stage I, II and IIIA). 85.6% of early and 73.1% of locally advanced breast cancers were disease free at 5 years (p<0.001).90.6% of early and 82.4% of locally advanced breast cancers had distant failure free survival at 5 years (p=0.001). Local failure free survival was 96.1% in both early and locally advanced breast disease at 5 years.94.9% of her 2 negative and 83.5% Her 2 positive were disease free at 5 years (p=0.001). 5 years progression free survival was 91.5% for breast conservation surgery vs 84.1% for mastectomy with axillary clearance (p=0.01). 75.4% with triple negative status and 80.8% non triple negative receptor status had 5 years DFS. Conclusion: This is a first report of survival patterns of breast cancer patients treated in a single centre in India. High early stage patient numbers and high median disease free survival times could be because of improvement in screening and treatment of breast cancer in a developing country like India.

Developing and evaluation of a new clinicopathologic response index after neoadjuvant chemotherapy as a predictor of clinical outcomes in locally advanced breast cancers.

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. 1083-1083
Author(s):  
Tarek M. A. Abdel-Fatah ◽  
Graham Ball ◽  
Andrew HS Lee ◽  
Sarah Pinder ◽  
R Douglas MacMilan ◽  
...  
Keyword(s):  
Neoadjuvant Chemotherapy ◽  
Clinical Outcomes ◽  
Locally Advanced ◽  
Advanced Breast ◽  
Breast Cancers ◽  
Response Index
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