Risk of Fracture After Androgen Deprivation for Prostate Cancer

2006 ◽  
Vol 2006 ◽  
pp. 151
Author(s):  
P.J. Loehrer
Keyword(s):  
Prostate Cancer ◽  
Androgen Deprivation ◽  
Risk Of Fracture

Risk of Fracture after Androgen Deprivation for Prostate Cancer

2005 ◽  
Vol 352 (2) ◽  
pp. 154-164 ◽  
Author(s):  
Vahakn B. Shahinian ◽  
Yong-Fang Kuo ◽  
Jean L. Freeman ◽  
James S. Goodwin
Keyword(s):  
Prostate Cancer ◽  
Androgen Deprivation ◽  
Risk Of Fracture

scholarly journals Risk of fracture in men with prostate cancer on androgen deprivation therapy: a population-based cohort study in New Zealand

BMC Cancer ◽  
2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Alice Wang ◽  
Zuzana Obertová ◽  
Charis Brown ◽  
Nishi Karunasinghe ◽  
Karen Bishop ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cohort Study ◽  
New Zealand ◽  
Androgen Deprivation Therapy ◽  
Population Based ◽  
Androgen Deprivation ◽  
Risk Of Fracture

scholarly journals Risk of Fracture During Androgen Deprivation Therapy Among Patients With Prostate Cancer: A Systematic Review and Meta-Analysis of Cohort Studies

2021 ◽  
Vol 12 ◽  
Author(s):  
Cheng Chih Wu ◽  
Po Yen Chen ◽  
Shih Wei Wang ◽  
Meng Hsuan Tsai ◽  
Yu Chin Lily Wang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cohort Studies ◽  
Fracture Risk ◽  
Androgen Deprivation Therapy ◽  
Meta Analysis ◽  
Androgen Deprivation ◽  
Cochrane Library ◽  
High Dose ◽  
Risk Of Fracture ◽  
Statistical Heterogeneity

Background: Androgen deprivation therapy (ADT) suppresses the production of androgen, and ADT is broadly used for intermediate or higher risk disease including advanced and metastatic cancer. ADT is associated with numerous adverse effects derived from the pharmacological properties. Previous meta-analysis on fracture risk among ADT users possessed limited data without further subgroup analysis. Risk estimation of updated real-world evidence on ADT-related fracture remains unknown.Objectives: To assess the risk of fracture and fracture requiring hospitalization associated with ADT among prostate cancer population on different disease conditions, treatment regimen, dosage level, fracture sites.Methods: The Cochrane Library, PubMed, and Embase databases were systematically screened for eligible cohort studies published from inception to March 2020. Two authors independently reviewed all the included studies. The risks of any fracture and of fracture requiring hospitalization were assessed using a random-effects model, following by leave-one-out, stratified, and sensitivity analyses. The Grading of Recommendations Assessments, Development and Evaluations (GRADE) system was used to grade the certainty of evidence.Results: Sixteen eligible studies were included, and total population was 519,168 men. ADT use is associated with increasing fracture risk (OR, 1.39; 95% CI, 1.26–1.52) and fracture requiring hospitalization (OR, 1.55; 95% CI, 1.29–1.88). Stratified analysis revealed that high-dose ADT results in an elevated risk of fracture with little statistical heterogeneity, whereas sensitivity analysis restricted to adjust for additional factors indicated increased fracture risks for patients with unknown stage prostate cancer or with no restriction on age with minimal heterogeneity. The GRADE level of evidence was moderate for any fracture and low for fracture requiring hospitalization.Conclusion: Cumulative evidence supports the association of elevated fracture risk with ADT among patients with prostate cancer, including those with different disease conditions, treatment regimens, dose levels, and fracture sites. Further prospective trials with intact information on potential risk factors on fracture under ADT use are warranted to identify the risky population.

Androgen deprivation in prostate cancer and the long-term risk of fracture

2017 ◽  
Vol 41 (8) ◽  
pp. 491-496
Author(s):  
S. Ojeda ◽  
M. Lloret ◽  
A. Naranjo ◽  
F. Déniz ◽  
N. Chesa ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Deprivation ◽  
Risk Of Fracture

598: Increased Risk of Newly Diagnosed Comorbidities in Prostate Cancer Patients Treated with Androgen Deprivation Therapy

2007 ◽  
Vol 177 (4S) ◽  
pp. 200-200 ◽  
Author(s):  
Andrea Gallina ◽  
Pierre I. Karakiewicz ◽  
Jochen Walz ◽  
Claudio Jeldres ◽  
Quoc-Dien Trinh ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Patients ◽  
Androgen Deprivation Therapy ◽  
Androgen Deprivation ◽  
Newly Diagnosed ◽  
Increased Risk
Sign in / Sign up

Export Citation Format

Share Document