Assessing Quality of Life During Chemotherapy for Pleural Mesothelioma: Feasibility, Validity, and Results of Using the European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire and Lung Cancer Module

2006 ◽  
Vol 2006 ◽  
pp. 245-246
Author(s):  
N.H. Hanna
Keyword(s):  
Quality Of Life ◽  
Lung Cancer ◽  
Pleural Mesothelioma ◽  
Life Questionnaire ◽  
European Organization ◽  
Quality Of Life Questionnaire ◽  
Cancer Module

Assessing Quality of Life During Chemotherapy for Pleural Mesothelioma: Feasibility, Validity, and Results of Using the European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire and Lung Cancer Module

2004 ◽  
Vol 22 (15) ◽  
pp. 3172-3180 ◽  
Author(s):  
Anna K. Nowak ◽  
Martin R. Stockler ◽  
Michael J. Byrne
Keyword(s):  
Quality Of Life ◽  
Lung Cancer ◽  
Pleural Mesothelioma ◽  
Life Questionnaire ◽  
European Organization ◽  
Quality Of Life Questionnaire ◽  
Cancer Module ◽  
Eortc Qlq C30 ◽  
Eortc Qlq

Purpose To assess the feasibility and validity of using the European Organization for Research and Treatment of Cancer (EORTC) Core Quality of Life Questionnaire (QLQ-C30) and Lung Cancer Module (QLQ-LC13) to describe health-related quality of life (HRQL) in patients with pleural mesothelioma undergoing combination chemotherapy, to identify the most impaired aspects of HRQL, and to assess the impact of chemotherapy on HRQL. Patients and Methods Fifty-three patients received cisplatin on day 1 and gemcitabine on days 1, 8, and 15 of a 28-day cycle for a maximum of six cycles. HRQL was assessed using the EORTC QLQ-C30 and QLQ-LC13. Results Compliance was 100% at baseline but subsequently decreased. At baseline, role function and social function were the most impaired domains, and the worst-rated symptoms were fatigue, dyspnea, pain, insomnia, appetite loss, and cough. Dyspnea, pain, insomnia, and cough improved with chemotherapy, although functional domains and chemotherapy-related symptoms deteriorated. Fatigue remained unchanged. Few patients reported hemoptysis. Functional domains and symptoms scales from the QLQ-C30 demonstrated predictive validity for survival. The predictive value of QLQ-LC13 pain scores was improved by combining three pain items into a single score. Dyspnea scores were correlated strongly with lung function as measured by forced vital capacity. Conclusion This study supports the validity of the EORTC QLQ-C30 and LC13 as outcome measures for trials of chemotherapy in mesothelioma. Although the most prominent symptoms reported were concordant with clinical experience, impairments in role and social function and insomnia were worse than expected. Future research should focus on how best to apply, analyze, and interpret existing, validated HRQL instruments in mesothelioma research and practice, not on the development of new ones.

scholarly journals Translation and cultural adaptation of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Lung Cancer Module for quality of life assessment in patients with lung cancer in Brazil

2019 ◽  
Vol 45 (4) ◽  
Author(s):  
Ana Paula Ramos Marinho ◽  
Gracielle Fin ◽  
Antuani Rafael Baptistella ◽  
Rudy José Nodari Júnior ◽  
Magnus Benetti
Keyword(s):  
Quality Of Life ◽  
Lung Cancer ◽  
Cultural Adaptation ◽  
Life Questionnaire ◽  
Pilot Testing ◽  
Language Version ◽  
Quality Of Life Questionnaire ◽  
European Organisation ◽  
Cancer Module

ABSTRACT Objective: To translate the European Organisation for Research and Treatment of Cancer (EORTC) 29-item Quality of Life Questionnaire-Lung Cancer Module (QLQ-LC29, developed for the assessment of quality of life in patients with lung cancer) to Portuguese, conducting a pilot study of the Portuguese-language version and adapting it for use in Brazil. Methods: For the translation, cultural adaptation, and pilot testing of the QLQ-LC29, we followed the guidelines established by the EORTC. The translation (English → Portuguese) and back-translation (Portuguese → English) were both carried out by translators, working independently, who were native speakers of one language and fluent in the other. After review, a draft version was created for pilot testing in lung cancer patients in Brazil. Results: A total of 15 patients diagnosed with lung cancer completed the Portuguese-language version of the questionnaire. At the end of the process, we conducted a structured interview to identify any patient difficulty in understanding any of the questions. The final versions were sent to the EORTC and were approved. Conclusions: The Portuguese-language version of the EORTC QLQ-LC29 appears to be a useful, important, reliable questionnaire that is a valid tool for assessing quality of life in patients with lung cancer in Brazil.

The European Organization for Research and Treatment of Cancer (EORTC) Quality-of-Life questionnaire cervical cancer module

Cancer ◽  
2006 ◽  
Vol 107 (8) ◽  
pp. 1812-1822 ◽  
Author(s):  
Elfriede R. Greimel ◽  
Karin Kuljanic Vlasic ◽  
Ann-Charlotte Waldenstrom ◽  
Vlatka M. Duric ◽  
Pernille T. Jensen ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cervical Cancer ◽  
Life Questionnaire ◽  
European Organization ◽  
Quality Of Life Questionnaire ◽  
Cancer Module ◽  
Eortc Quality

Cinesioterapia para melhora da qualidade de vida após cirurgia para câncer de mama

2021 ◽  
Vol 22 (3) ◽  
pp. 385-397
Author(s):  
Helena Yannael Bezerra Domingos ◽  
Sarah Santos Moreira ◽  
Mikael Santos Alves ◽  
Fernanda Bispo Oliveira ◽  
Caroline Bomfim Lemos da Cruz ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Cáncer De Mama ◽  
Life Questionnaire ◽  
European Organization ◽  
Quality Of Life Questionnaire ◽  
Cancer Module ◽  
C 30

Introdução: O tratamento cirúrgico para o câncer de mama pode trazer limitações físico-funcionais e prejuízos na qualidade de vida (QV). Assim, a cinesioterapia representa uma possibilidade terapêutica para prevenir ou tratar estas disfunções. Objetivo: Comparar a QV antes e após 10 sessões de cinesioterapia. Métodos: Ensaio clínico não aleatorizado, envolvendo mulheres que realizaram 10 sessões de fisioterapia após cirurgia para câncer de mama. O protocolo incluiu alongamentos, exercícios ativos-livres e exercícios resistidos. A QV foi avaliada pelo questionário genérico European Organization for Research and Treatment of Cancer (EORTC): o Quality of Life Questionnaire C-30 (QLQ-C30) e o específico, Breast Cancer Module (BR-23). Resultados: Foram incluídas 35 mulheres, sendo a mastectomia à esquerda o procedimento mais realizado. No QLQ-C30, foi observada melhora significativa da escala de função física (p = 0,01), desempenho funcional (p = 0,02), fadiga (p = 0,03), dor (p = 0,01), insônia (p = 0,02) e piora apenas de diarreia (p = 0,02). No BR-23, observou-se melhora significativa nos sintomas da mama (p = 0,01) e do braço (p = 0,01). Outros escores, como função cognitiva, social, dispneia, constipação, dificuldade financeira, imagem corporal e perspectiva futura, melhoraram sem diferença significativa. Conclusão: Após a cinesioterapia, observou-se melhora de diversos aspectos da QV. Maior tempo de seguimento e outros instrumentos de avaliação poderão mostrar ganhos adicionais.

scholarly journals Genetic polymorphisms and haplotypes of ERCC1 and ERCC2 associated with quality of life, depression, and anxiety status among patients with lung cancer

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yunxiang Tang ◽  
Ruike Zhang ◽  
Yinan Li ◽  
Shuyu Xu ◽  
Hao Wang ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Lung Cancer ◽  
Cognitive Function ◽  
Emotional Functioning ◽  
Life Questionnaire ◽  
Depression And Anxiety ◽  
European Organization ◽  
Quality Of Life Questionnaire ◽  
The Relationship

Abstract Background Patients with lung cancer (LC) have a poor quality of life (QoL) and easily suffer from psychological diseases. Previous studies focused less on the relationship between genetic factors and QoL, depression, and anxiety status in LC patients. The current study is intended to explore the relationship between SNPs and haplotypes of ERCC1 and ERCC2 and the QoL, depression and anxiety status of patients with LC. Methods QoL, depression and anxiety status were assessed in 291 LC patients using the European Organization for Research and Treatment of Cancer (EORTC) Core Quality of Life Questionnaire (QLQ-C30), EORTC Quality of Life Questionnaire-Lung Cancer 13 (QLQ-LC13), SDS and SAS. Nine tag SNPs of ERCC1 and ERCC2 were detected using an improved multiplex ligation detection reaction (iMLDR) technique. Haplotype analysis was conducted using the software Haploview 4.2. The association between SNPs or haplotypes and QoL or depression or anxiety in LC patients was analyzed by regression analysis. Results ERCC1 rs11615 was associated with emotional functioning (P = 0.027), and ERCC1 rs3212986 was associated with anxiety scores (P = 0.018). ERCC1 rs762562-rs3212986 haplotype was associated with cognitive function (P = 0.029), somatic function (P = 0.014) and dysphagia (OR = 3.32, P = 0.044). Patients with ERCC1 rs3212986-rs11615 AG haplotype had worse cognitive function (adjusted Beta = − 5.42) and somatic function (adjusted Beta = − 6.55) and had severer symptoms of loss of appetite (adjusted OR = 1.67) and dysphagia (adjusted OR = 4.43) (All adjusted P < 0.05). ERCC2 rs13181-rs3916874-rs238416 haplotype was associated with emotional functioning (P = 0.035), pain at other sites (OR 1.88, P = 0.014), chest pain (OR 0.42, P = 0.02), dysphagia (OR 2.82, P = 0.048), and anxiety status (OR 0.23, P = 0.009). Conclusion After adjustment for environmental factors, SNPs and haplotypes of ERCC1 and ERCC2 were associated with different domains of QoL, depression and anxiety in LC patients.

scholarly journals Psychosocial assessment of lung cancer patients and their caregivers

2021 ◽  
Vol 39 (1) ◽  
pp. 77-91
Author(s):  
Cátia Andreia Clara ◽  
Sara Otília Marques Monteiro ◽  
Ana Cláudia Pereira Bártolo
Keyword(s):  
Quality Of Life ◽  
Lung Cancer ◽  
Depressive Symptomatology ◽  
Financial Burden ◽  
Depression Scale ◽  
Anxiety And Depression ◽  
Life Questionnaire ◽  
European Organization ◽  
Quality Of Life Questionnaire

Lung cancer (LC) is one of the most common types of cancer disease worldwide. Studies in the field show that the appearance of a pathology of this form causes changes not only in the patient’s life, namely psychological problems, functional limitations and poorer health due to the clinical consequences of treatments, but also in their family, where caregivers often face the challenge of providing long-term daily care that induces a physical, psychosocial and financial burden (Borges et al., 2017; Hewitt et al., 2003; Tan et al., 2018). The main objective of the present study is to compare and relate the two groups (patients and caregivers) considering the quality of life (QoL) and symptoms of psychological distress (anxiety and depression). The total sample consisted of 30 patient/caregiver dyads. The instruments used were: Hospital Anxiety and Depression Scale; European Organization for Research and Treatment of Quality of Life Questionnaire (EORTC QLQ C-30) and its specific module for lung cancer (LC13); Caregiver Oncology Quality of Life Questionnaire (CarGOQoL) and Zarit Burden Interview Scale (ZBI). The results suggest the influence of depressive symptomatology on patients’ QoL [F(1)=6.390; p<0.05] and depressive and anxious symptomatology and burden on caregivers’ QoL [F(3)=7.815; p<0.001]. A positive association was found between depressive symptomatology of patients and caregivers (r=0.458; p=0.011) and differences in anxious symptomatology were also observed, with a higher result in the patient’s group.

scholarly journals Identificação de Conceitos da Classificação Internacional de Funcionalidade, Incapacidade e Saúde em Medidas de Qualidade de Vida para o Câncer do Colo do Útero

2018 ◽  
Vol 64 (4) ◽  
pp. 509-516
Author(s):  
Luciana Castaneda ◽  
Juliana Cossich Trindade Alves ◽  
Thaissa Hamana de Macedo Dantas ◽  
Diego de Sousa Dantas
Keyword(s):  
Quality Of Life ◽  
Cervical Cancer ◽  
Cancer Therapy ◽  
Functional Assessment ◽  
Life Questionnaire ◽  
European Organization ◽  
Quality Of Life Questionnaire ◽  
Cancer Module

Introdução: o câncer do colo do útero apresenta elevada incidência em países de baixa e média rendas e provoca repercussões negativas sobre a funcionalidade das mulheres. o interesse na mensuração de medidas terapêuticas, que não se restrinjam às medidas do modelo biomédico, vem assumindo destaque no campo da oncologia. a classificação internacional de Funcionalidade (ciF) aparece no cenário mundial como ferramenta de orientação para construção da avaliação biopsicossocial. Objetivo: exemplificar a metodologia para identificação dos componentes da funcionalidade em escalas específicas utilizadas no cuidado oncológico para mulheres com câncer do colo do útero. Método: estudo realizado em três etapas: análise de revisões sistemáticas para identificação dos instrumentos específicos para avaliação de câncer do colo do útero; extração das medidas de avaliação; e ligação dos conceitos contidos nas medidas de desfecho com as categorias correspondentes da ciF por dois revisores independentes. Resultados: na análise do Functional Assessment of Cancer Therapy-Cervix e do European Organization for Research and Treatment of Cancer Quality-of-Life Questionnaire Cervical Cancer Module, identificaram-se 72 conteúdos principais ligados a 35 categorias da ciF. destas, 23 referiam-se às funções corporais, oito às atividades e participação, três aos fatores ambientais e uma à estrutura corporal. Conclusão: os dois instrumentos possuem ligação com a ciF, no entanto, exploram de forma insuficiente os fatores contextuais, o que demonstra a necessidade de orientação biopsicossocial nas avaliações em saúde para mulheres com câncer do colo do útero de maneira a contemplar, de forma equânime, os componentes da funcionalidade na aferição dos desfechos terapêuticos.

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