The future of cancer care: Experimental immunotherapy meets genetic engineering

2013 ◽  
Vol 19 (8) ◽  
pp. 2-4
Author(s):  
Amy K. Erickson
Author(s):  
John Parrington

We can now edit genomes. The technique, which involves cutting and pasting DNA code into the genome, is faster and cheaper than traditional genetic engineering and can be used on almost any animal or plant. What will this technology mean for the future? It may pave the way to banishing many diseases, and help feed the burgeoning population of the world. Woolly mammoths may again roam the tundra. But are there also risks? Might a nightmarish world of bioterrorism and rogue synthetic organisms await? John Parrington reports on the astonishing revolution underway in genetic engineering and why it matters to us all.


Author(s):  
Jorge Sierra Merchán

ResumenEn la discusión sobre las implicaciones éticas de la ingeniería genética, es común establecer una diferencia entre eugenesia negativa y eugenesia positiva. La eugenesia negativa está conformada por procedimientos orientados a corregir defectos genéticos, es decir, a evitar o minimizar la trasmisión de enfermedades hereditarias. La eugenesia positiva consiste en potenciar u optimizar caracteres que se consideran deseables (belleza o inteligencia). Una cosa es reparar, con fines terapéuticos, un error genético y otra cosa es mejorar genéticamente un rasgo que se considera bueno y deseable. En este sentido cabe preguntarse: ¿hay un deber moral de evitar, mediante la ingeniería genética, que los niños nazcan con discapacidades y no se les condene a una vida de desgracia? ¿O hay también un deber moral equivalente de garantizar que los niños posean belleza e inteligencia? El presente texto busca responder ambas cuestiones mediante una evaluación de los argumentos en pro y en contra de la eugenesia desarrollados por Singer y Nussbaum. Sostendré que hay una obligación moral de aplicar la eugenesia negativa, mientras que tal obligación no es extensiva para el caso de la eugenesia positiva. Esto implica que no es posible exigir un presunto derecho a ser desgraciado ni desde el punto de vista de los padres ni desde el punto de vista de los futuros hijos para el caso de la eugenesia negativa, en tanto que para el caso de la eugenesia positiva el derecho a ser desgraciados parece ser más defendible. Palabras clave: Eugenesia, genoma humano, principio preventivo, Singer, Nussbaum**********************************************************Is it possible to claim a alleged right to be disgraced? The “happy world” of eugenicsAbstractIn the discussion about the ethical implications of genetic engineering it is usual to distinguish between negative and positive eugenics. Negative eugenics refers to genetic imperfections correction procedures, which aim to avoid or minimize the transmission of hereditary diseases. Positive eugenics consists in the improvement or optimization of features considered desirable (as beauty or intelligence). One thing is to repair, for therapeutic purposes, a genetic error, and another to genetically improve a feature considered good and desirable. In this sense one could ask if it is a moral duty to avoid, through genetic engineering, impairments in newborns, saving them from an unfortunate life; and if there is also an equivalent moral duty to guarantee that children possess beauty and intelligence. This paper aims to answer both questions through an evaluation of the arguments for and against eugenics proposed by Singer and Nussbaum. I will hold that though there is a moral obligation to apply negative eugenics, this kind of obligation is not present in the case of positive eugenics. This implies that it is not possible to demand a presumed right to be miserable, either from the parent’s or the future children’s point of view, in the case of negative eugenics, although this presumed right to be miserable seems to be more defensible in the case of positive eugenics. Key words: Eugenics, human genome, preventive principle, Singer, Nussbaum.**********************************************************É possível reclamar um alegado direito a ser desgraçado? O “mundo feliz” da eugenesiaResumoNa discussão sobre as implicações éticas da engenharia genética é frequente estabelecer uma diferenciação entre eugenesia negativa e eugenesia positiva. A eugenesia negativa está conformada pelos procedimentos orientados a corrigir defeitos genéticos, ou seja, evitar ou minimizar a transmissão de doenças hereditárias. A eugenesia positiva consiste em potenciar ou aperfeiçoar caracteres que se consideram desejáveis (beleza ou inteligência). Uma coisa é reparar, com fins terapêuticos, um erro genético, e outra coisa é melhorar geneticamente um traço que se considera bom ou desejável, Nesse sentido é possível perguntar: há o dever moral de evitar, mediante a engenharia genética, que as crianças nasçam com incapacidades e não sejam condenados a uma vida de desgraça? Ou há também um dever moral equivalente de que as crianças possuam beleza e inteligência? O presente texto procura responder ambas as questões mediante uma avaliação dos argumentos em prol e em contra da eugenesia desenvolvidos por Singer e Nussbaum. Vou suster que há uma obrigação moral de aplicar a eugenesia negativa, enquanto que tal obrigação não é extensiva para o caso da eugenesia positiva. Isto implica que não é possível exigir um pressuposto direito a ser desgraçado nem desde o ponto de vista dos pais nem desde o ponto de vista dos futuros filhos no caso da eugenesia negativa, em tanto que no caso da eugenesia positiva o direito a ser desgraçados parece ser mais defendível. Palavras chave: Eugenesia, genoma humano, princípio preventivo, Singer, Nussbaum.


1990 ◽  
Vol 5 (2) ◽  
pp. 3-6
Author(s):  
Lee E. Mortenson
Keyword(s):  

2018 ◽  
Vol 51 (3) ◽  
pp. 319-338 ◽  
Author(s):  
Yvonne Jewkes

This article develops the notion that institutional places and spaces are layered with meaning and that their architecture and design have a profound psychological and physiological influence on those who live and work within them. Mindful of the intrinsic link between ‘beauty’ and ‘being just’, the article explores the potential ‘healing’ or rehabilitative role of penal aesthetics. As many countries modernise their prison estates, replacing older facilities that are no longer fit-for-purpose with new, more ‘efficient’ establishments, this article discusses examples of international best (and less good) practice in penal and hospital settings. It reflects on what those who commission and design new prisons might learn from pioneering design initiatives in healthcare environments and asks whether the philosophies underpinning the ‘architecture of hope’ that Maggie’s Cancer Care Centres exemplify could be incorporated into prisons of the future. The article was originally presented as a public lecture in the annual John V Barry memorial lecture series at the University of Melbourne on 24 November 2016.


2019 ◽  
Vol 20 (2) ◽  
pp. 341 ◽  
Author(s):  
Dik-Lung Ma ◽  
Chun Wu ◽  
Sha-Sha Cheng ◽  
Fu-Wa Lee ◽  
Quan-Bin Han ◽  
...  

Platinum-based drugs have revolutionized cancer care, but are unfortunately associated with various adverse effects. Meanwhile, natural product scaffolds exhibit multifarious bioactivities and serve as an attractive resource for cancer therapy development. Thus, the conjugation of natural product scaffolds to metal complexes becomes an attractive strategy to reduce the severe side effects arising from the use of metal bearing drugs. This review aims to highlight the recent examples of natural product-conjugated metal complexes as cancer therapies with enhanced selectivity and efficacy. We discuss the mechanisms and features of different conjugate complexes and present an outlook and perspective for the future of this field.


JAMA Oncology ◽  
2020 ◽  
Vol 6 (3) ◽  
pp. 327 ◽  
Author(s):  
Lawrence N. Shulman ◽  
Lisa Kennedy Sheldon ◽  
Edward J. Benz

2001 ◽  
Vol 49 (6) ◽  
pp. 281-282
Author(s):  
Paula Trahan Rieger
Keyword(s):  

2008 ◽  
Vol 45 (4) ◽  
pp. 383-399 ◽  
Author(s):  
I. D. Godwin ◽  
S. B. Williams ◽  
P. S. Pandit ◽  
H. K. C. Laidlaw

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