Swainsonine stimulates bone marrow cell proliferation and differentiation in different strains of inbred mice

Carbon dots derived from nopal significantly increase the number of micronuclei in mouse erythrocytes and inhibit mouse bone marrow cell proliferation.

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Disturbed Bone Marrow Cell Proliferation in Primary Shunt Hyperbilirubinemia

Blood ◽

10.1182/blood.v41.4.539.539 ◽

1973 ◽

Vol 41 (4) ◽

pp. 539-547 ◽

Cited By ~ 6

Author(s):

Jack W. Hamer ◽

Peter H. Fitzgerald

Keyword(s):

Cell Cycle ◽

Bone Marrow ◽

Cell Proliferation ◽

Bone Marrow Cell ◽

Marrow Cell ◽

Myeloid Cells ◽

Early Release

Abstract Cell proliferation studies, utilizing 3H-thymidine radioautography combined with quantitative DNA microdensitometry, demonstrated a gross disturbance of bone marrow cell proliferation in a 17-yr-old youth with primary shunt hyperbilirubinemia. Early erythroid and myeloid cells were arrested at the S, G2 and mitotic phases of the cell cycle, but late normoblasts were not affected. Intramedullary death of the abnormal early erythrmoid cells probably results and is compensated by increased hemopoiesis with a hyperplastic marrow, which 59Fe studies suggest leads to the production and early release of "stress" reticulocytes. The increased early bilirubin production that characterizes this disorder is considered to be derived primarily from intramedullary death of early normoblasts and secondarily from hemolysis in the marrow and spleen of stress reticulocytes.

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Effect of titanium surface roughness on human bone marrow cell proliferation and differentiation: an experimental study

Acta Cirurgica Brasileira ◽

10.1590/s0102-86502009000300007 ◽

2009 ◽

Vol 24 (3) ◽

pp. 200-205 ◽

Cited By ~ 21

Author(s):

Taís Somacal Novaes Silva ◽

Denise Cantarelli Machado ◽

Christian Viezzer ◽

Aurelício Novaes Silva Júnior ◽

Marília Gerhardt de Oliveira

Keyword(s):

Bone Marrow ◽

Surface Roughness ◽

Cell Proliferation ◽

Marrow Cell ◽

Human Bone ◽

Human Bone Marrow ◽

Human Donor ◽

Proliferation And Differentiation ◽

Titanium Surfaces ◽

Intermediate Surface

PURPOSE: To assess the proliferation and differentiation of human bone marrow-derived cells cultured on titanium surfaces with different roughness characteristics. METHODS: Cells obtained from the iliac crest of an adult human donor were routinely processed and cultured on titanium surfaces of varying roughness, according to their preparation method: polishing only (smooth surface) and polishing followed by etching with HF/HNO3 for 15 and 30 minutes (rough surfaces). Surfaces were assessed using scanning electronic microscopy and profilometry. RESULTS: Titanium disks etched with acid for 15 minutes allowed greater cell proliferation in all culture periods. The level of osteopontin and osteocalcin expression was increased in both acid-etched groups, which indicates an advanced stage of differentiation of cells into osteoblasts. CONCLUSIONS: Increased surface roughness accelerates the differentiation of undifferentiated mesenchymal cells into osteogenic lineage cells, but does not necessarily favor cell proliferation. An intermediate surface roughness of 0.5µm (acid etching for 15 minutes) favors both initial and final cell responses.

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