Clinical features, vascular risk factors, and prognosis for transient global amnesia in Chinese patients

1999 ◽  
Vol 8 (5) ◽  
pp. 295-299 ◽  
Author(s):  
Sien T. Chen ◽  
Lok M. Tang ◽  
Wen C. Hsu ◽  
Tsong H. Lee ◽  
Long S. Ro ◽  
...  
Keyword(s):  
Risk Factors ◽  
Clinical Features ◽  
Transient Global Amnesia ◽  
Vascular Risk Factors ◽  
Chinese Patients ◽  
Vascular Risk ◽  
Global Amnesia

Vascular Risk Factors and Internal Jugular Venous Flow in Transient Global Amnesia: A Study of 165 Japanese Patients

2017 ◽  
Vol 26 (10) ◽  
pp. 2272-2278 ◽  
Author(s):  
Takahiro Himeno ◽  
Masaru Kuriyama ◽  
Makoto Takemaru ◽  
Yuhei Kanaya ◽  
Yuji Shiga ◽  
...  
Keyword(s):  
Risk Factors ◽  
Transient Global Amnesia ◽  
Japanese Patients ◽  
Vascular Risk Factors ◽  
Vascular Risk ◽  
Venous Flow ◽  
Global Amnesia

scholarly journals Intracranial arterial stenosis in Caucasian versus Chinese patients with TIA and minor stroke: two contemporaneous cohorts and a systematic review

2021 ◽  
pp. jnnp-2020-325630
Author(s):  
Xinyi Leng ◽  
Robert Hurford ◽  
Xueyan Feng ◽  
Ka Lung Chan ◽  
Frank J Wolters ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hong Kong ◽  
Vascular Risk Factor ◽  
Vascular Risk Factors ◽  
Arterial Stenosis ◽  
Chinese Patients ◽  
Minor Stroke ◽  
Vascular Risk ◽  
Intracranial Arterial Stenosis ◽  
Different Populations

BackgroundIntracranial arterial stenosis (ICAS) is an important cause of stroke worldwide. Separate reports in Caucasians and Asians with stroke/transient ischaemic attack (TIA) have suggested lower ICAS prevalence in Caucasians, but there has been no direct comparisons of the two ethnic groups with the same criteria to define ICAS.MethodsAcute minor stroke or TIA patients in two cohorts respectively recruiting patients in Oxford (2011–2018, predominantly Caucasians) and Hong Kong (2011–2015, predominantly Chinese) were compared. ICAS was defined as ≥50% stenosis/occlusion in any major intracranial artery in MR/CT angiography. Prevalence, distribution and risk factors of ICAS were compared between the two cohorts. We also systematically reviewed literature on ICAS prevalence in stroke/TIA patients in different populations.ResultsAmong 1287 patients from Oxford and 691 from Hong Kong (mean age 69 vs 66), ICAS prevalence was higher in Chinese than in Caucasians (43.0% vs 20.0%; OR 3.02; 95% CI 2.47 to 3.70; p<0.001), independent of age (age-adjusted OR 3.73; 95% CI 3.00 to 4.63; p<0.001) and vascular risk factors (multivariable-adjusted OR 3.21; 95% CI 2.56 to 4.02; p<0.001). This ethnic difference was greater (p interaction=0.005) at age <70 years (OR 5.33; 95% CI 3.79 to 7.50; p<0.001) than at ≥70 years (OR 2.81; 95% CI 2.11 to 3.74; p<0.001). ICAS prevalence increased with age and with vascular risk factors in both cohorts, with equivalent prevalence in Chinese aged <60 years and Caucasians aged ≥80, and in Chinese with no vascular risk factor and Caucasians with two vascular risk factors. ICAS locations also differed between Chinese and Caucasian patients.ConclusionsChinese are more susceptible to ICAS than Caucasians, with an earlier onset age and a higher prevalence, independent of vascular risk factors.

Clinical features, risk factors, and prognosis in transient global amnesia: a follow-up study

2005 ◽  
Vol 12 (5) ◽  
pp. 350-356 ◽  
Author(s):  
L. Pantoni ◽  
E. Bertini ◽  
M. Lamassa ◽  
G. Pracucci ◽  
D. Inzitari
Keyword(s):  
Risk Factors ◽  
Clinical Features ◽  
Transient Global Amnesia ◽  
Follow Up Study ◽  
Global Amnesia

scholarly journals Clinical features of hemichoreahemiballism: A stroke-related movement disorder

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Nobuko Shiraiwa ◽  
Sachiko Hoshino ◽  
Go Saito ◽  
Akira Tamaoka ◽  
Norio Ohkoshi
Keyword(s):  
Risk Factors ◽  
Basal Ganglia ◽  
Clinical Features ◽  
Symptom Control ◽  
Acute Onset ◽  
Vascular Risk Factors ◽  
Vascular Lesions ◽  
Gamma Aminobutyric Acid ◽  
Vascular Risk ◽  
Imaging Results

We examined pathogenesis and clinical features of three hemichorea-hemiballism (HCHB) cases. We studied their age, magnetic resonance imaging results, vascular risk factors, management, and outcomes. One man and two women (aged 74-86 years) demonstrated acute onset of HCHB, lasting for at least several months. Patients had one or more vascular risk factors, including hypertension and diabetes. All patients presented subacute or old infarction in the basal ganglia with contralateral symptoms. We administered clonazepam (0.5-1 mg/day), haloperidol (0.375-0.75 mg/day), or both as necessary and observed symptom-control. Vascular lesions in the basal ganglia were a contributing factor. Symptoms were controlled using pharmacotherapy with gamma-aminobutyric acid-agonist (clonazepam) or anti-dopaminergic (haloperidol) medication.

Abstract WP230: No Difference of Cerebral Perfusion Between Transient Global Amnesia With and Without Acute Focal Lesion in Hippocampus

Stroke ◽  
2016 ◽  
Vol 47 (suppl_1) ◽  
Author(s):  
Seong Hwan Ahn ◽  
Ji Yeon Chung ◽  
In Sung Choo ◽  
Kyung Yul Lee ◽  
Hyun Goo Kang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Clinical Features ◽  
Perfusion Defect ◽  
Cerebral Perfusion ◽  
Transient Global Amnesia ◽  
Focal Lesion ◽  
Symptom Duration ◽  
Temporal Region ◽  
Diffusion Weighted Images ◽  
Global Amnesia

Introduction: In transient global amnesia (TGA), the etiology or pathogenesis is still in debate. It has been commonly suggested that TGA might be related to an ischemic event, migraine, or epileptic seizures. With the characteristic findings of diffusion-weighted images (DWI), cerebrovascular disease can be regarded as a cause of TGA. Hypothesis: Transient global amnesia may be associated with regional cerebral perfusion, especially in patients with DWI lesions. The aim of the present study is to reveal the clinical or radiological difference between TGA patients with and without acute lesions. Methods: We identified retrospectively TGA patients who fulfilled the standard criteria from January 2010 through March 2015. Within 72 hours from symptom onset, all patients were evaluated with brain MR images and an electroencephalography. According to the presence of acute lesion in the hippocampus, clinical features, vascular risk factors, and regional perfusion status with SPECT images were compared. Results: Of 61 TGA patients (mean age 60.6, female 18 patients), 20 patients had acute focal lesions in the hippocampus (size: 3.36 ± 0.64mm, 7 in the right, 9 in the left, and 2 in bilateral lesions). All lesions were located in the lateral border (CA1 region) of the hippocampus. In the comparison of clinical features, the duration of amnestic symptom was shorter in the lesion negative group than in the lesion positive group (5 hours, IQR 2.5-8.8 vs. 8 hours, IQR 5-13.5, p=0.07). However, there was no difference between TGA patients with and without DWI lesions in cerebrovascular risk factors or laboratory results. Of 23 patients underwent a cerebral SPECT, 6 patients who had DWI lesions had no abnormal findings. Of 17 patients without lesions, only 3 patients exhibited mild focal perfusion defect in both medial temporal, left frontal, and left fronto-temporal region, respectively. Conclusions: Except amnestic symptom duration, we failed to reveal any clinical difference including perfusion defect between TGA patients with and without DWI lesion. It might suggest the low probability of hypoperfusion in the hippocampus regardless of the presence of brain DWI lesions.

The Spectrum of Cerebrovascular Disease and Associated Cognitive Decline

2019 ◽  
pp. 574-599
Author(s):  
Victoria J. Williams ◽  
Steven E. Arnold ◽  
David H. Salat
Keyword(s):  
Risk Factors ◽  
Cognitive Impairment ◽  
Cerebrovascular Disease ◽  
Cognitive Decline ◽  
Vascular Dementia ◽  
Structure And Function ◽  
Vascular Risk Factors ◽  
Vascular Health ◽  
Vascular Risk ◽  
And Function

Throughout the lifespan, common variations in systemic health and illness contribute to alterations in vasculature structure and function throughout the body, significantly increasing risk for cardiovascular and cerebrovascular disease (CVD). CVD is a prevalent cause of mortality in late life; it also promotes brain alterations, contributing to cognitive decline and, when severe, vascular dementia. Even prior to diseased states, individual variation in CVD risk is associated with structural and functional brain alterations. Yet, how cumulative asymptomatic alterations in vessel structure and function contribute to more subtle changes in brain tissue integrity and function that emerge in late life is unclear. Finally, vascular risk factors are associated with the clinical progression of neurodegenerative diseases such as Alzheimer’s disease (AD); however, recent theory posits that vascular degeneration may serve a contributory role in these conditions. This chapter reviews how lifespan changes in vascular health contribute to degenerative changes in neural tissue and the subsequent development of cognitive impairment and/or vascular dementia. It first discusses associations between vascular risk factors and cognition and also how declining vascular health may lead to cognitive impairment and dementia. Next, it identifies basic aspects of cerebrovascular anatomy and physiology sustaining tissue health and discusses how vulnerabilities of this system contribute to neurodegenerative changes. Finally, it reviews evidence of vascular contributions to AD and presents ideas for future research to better understand the full spectrum of cerebrovascular contributions to brain aging, cognitive decline, and dementia.

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