Prognostic indicators of outcomes in patients with distant metastases from differentiated thyroid carcinoma

2003 ◽  
Vol 197 (2) ◽  
pp. 191-197 ◽  
Author(s):  
Margo Shoup ◽  
Alexander Stojadinovic ◽  
Aviram Nissan ◽  
Ronald A Ghossein ◽  
Sam Freedman ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Distant Metastases ◽  
Differentiated Thyroid Carcinoma ◽  
Prognostic Indicators

Differentiated thyroid carcinoma with distant metastases at diagnosis: how we do it

2011 ◽  
Vol 36 (4) ◽  
pp. 380-383
Author(s):  
S. Turanli ◽  
M.U. Yuksel ◽  
C. Ozdilekcan ◽  
A. Cetin
Keyword(s):  
Thyroid Carcinoma ◽  
Distant Metastases ◽  
Differentiated Thyroid Carcinoma

scholarly journals A case of papillary thyroid cancer with soft tissue metastasis

2018 ◽  
Vol 5 (10) ◽  
pp. 3425 ◽  
Author(s):  
Jayan Stephen ◽  
Mebin B. Thomas ◽  
Mathew B. Thomas
Keyword(s):  
Thyroid Cancer ◽  
Soft Tissue ◽  
Thyroid Carcinoma ◽  
Papillary Thyroid Cancer ◽  
Distant Metastases ◽  
Differentiated Thyroid Carcinoma ◽  
Metastatic Tumour ◽  
Papillary Thyroid ◽  
Soft Tissue Metastasis ◽  
Regional Lymph Nodes

Papillary thyroid cancer is the most common thyroid malignancy, and although metastatic spread is typically confined to regional lymph nodes, there are rare documented cases of distant spread of disease. Distant metastases of differentiated thyroid cancer are unusual; lung and bones are the most frequently affected sites. Soft tissue metastases are extremely rare. Here we present an unusual case of soft tissue metastasis of papillary thyroid cancer to skeletal muscle. Soft tissue metastasis is rarely seen in differentiated thyroid carcinoma. Differentiated thyroid carcinoma, although generally clinically indolent, may occasionally develop distant metastases and even manifest itself as a metastatic tumour.

scholarly journals Histology does not influence prognosis in differentiated thyroid carcinoma when accounting for age, tumour diameter, invasive growth and metastases

2009 ◽  
Vol 160 (4) ◽  
pp. 619-624 ◽  
Author(s):  
Frederik A Verburg ◽  
Uwe Mäder ◽  
Markus Luster ◽  
Christoph Reiners
Keyword(s):  
Thyroid Carcinoma ◽  
Cox Regression ◽  
Tumour Size ◽  
Retrospective Chart Review ◽  
Distant Metastases ◽  
Differentiated Thyroid Carcinoma ◽  
Disease Stage ◽  
Cancer Specific Survival ◽  
Kaplan Meier ◽  
Extrathyroidal Invasion

ObjectivePapillary thyroid carcinoma (PTC) and follicular thyroid carcinoma (FTC) show considerable differences in disease stage at initial presentation. The aim of this study was to investigate whether there are differences in tumour-specific survival if initial staging is accounted for.DesignRetrospective chart review study.PatientsThe study sample comprised 875 PTC and 350 FTC patients (856 females, 369 males, mean age 47.8 years) treated in our hospital from 1978 to 2002. All patients received total thyroidectomy with subsequent I-131 ablation except for those patients with an isolated papillary microcarcinoma.MethodsKaplan–Meier analyses and Cox-regression analyses were performed to assess the influence of histology on thyroid cancer-specific survival.ResultsFTC patients were on average older, more likely to be male, presented with a larger tumour and more frequently had multifocal carcinoma and distant metastases than PTC patients, whereas they presented less frequently with extrathyroidal invasion or lymph node metastases. Twenty-year tumour-specific survival in PTC was 90.6% and in FTC 73.7% (P<0.001). In multivariate analysis the presence of distant metastases (P<0.001), age (P<0.001), tumour size (P=0.001) and the presence of extrathyroidal invasion (P=0.007), but not histology (P=0.26), were independent determinant variables for tumour-specific survival.ConclusionThere is no difference in tumour-specific survival between PTC and FTC when accounting for the presence of metastases, age, tumour size and the presence of extrathyroidal invasion.

The Importance of Age over Radioiodine Avidity as a Prognostic Factor in Differentiated Thyroid Carcinoma with Distant Metastases

Thyroid ◽  
2009 ◽  
Vol 19 (3) ◽  
pp. 227-232 ◽  
Author(s):  
Jasna Mihailovic ◽  
Ljubomir Stefanovic ◽  
Milica Malesevic ◽  
Branko Markoski
Keyword(s):  
Prognostic Factor ◽  
Thyroid Carcinoma ◽  
Distant Metastases ◽  
Differentiated Thyroid Carcinoma

scholarly journals Primary tumour size is a prognostic parameter in patients suffering from differentiated thyroid carcinoma with extrathyroidal growth: results of the MSDS trial

2010 ◽  
Vol 163 (4) ◽  
pp. 637-644 ◽  
Author(s):  
Jan Alexander Krämer ◽  
Kurt Werner Schmid ◽  
Henning Dralle ◽  
Markus Dietlein ◽  
Harald Schicha ◽  
...  
Keyword(s):  
Overall Survival ◽  
Thyroid Carcinoma ◽  
Tnm Classification ◽  
Tumour Size ◽  
Primary Tumour ◽  
Distant Metastases ◽  
Differentiated Thyroid Carcinoma ◽  
Thyroid Carcinomas ◽  
Tumour Diameter ◽  
The Relationship

ObjectiveThe Multicentre Study Differentiated Thyroid Cancer (MSDS) collective represents a well-defined group of patients with thyroid carcinomas with extrathyroidal extension. The aim of the present study was to evaluate the relationship of the primary tumour size with clinicopathological features as well as the outcome of patients with minimum and extensive extrathyroidal growth (pT3b- and pT4a-tumours; UICC 2002/2003, 6th ed).MethodsThe tumour diameter was available in 324 out of 351 MSDS patients (244 females, 80 males). Mean age of patients was 47.7±12.0 years (range, 20.1–69.8 years), and the median follow-up was 6.2 years. The relationship between primary tumour size and the following clinicopathological data was investigated: age, gender, histological tumour type (papillary thyroid carcinomas (PTC) versus follicular thyroid carcinomas (FTC)) and UICC/AJCC TNM classification. In addition, the correlation between primary tumour size and event-free and overall survival was assessed.ResultsThe FTC of our series were significantly larger than PTC (3.46 vs 1.84 cm;P<0.001). Patients suffering from pT3b-tumours presented with significantly smaller tumour size than those with extensive extrathyroidal growth (pT4a-tumours) (1.9 vs 3.0 cm;P<0.01). All patients with distant metastases suffered from tumours >2 cm. Furthermore, event-free and overall survival were significantly correlated with increasing tumour size (P<0.05). Using multivariate analysis, a pT4a-category and a tumour diameter >2 cm remained independent predictors of survival.ConclusionsIn patients suffering from differentiated thyroid carcinoma with extrathyroidal growth (pT3b and pT4a), the tumour size is an independent predictor of event-free and overall survival.

Metastatic follicular thyroid carcinoma to the paranasal sinuses: a case report and review

1997 ◽  
Vol 111 (7) ◽  
pp. 647-651 ◽  
Author(s):  
Ken W. Altman ◽  
Natasha Mirza ◽  
Lucien Philippe
Keyword(s):  
Thyroid Carcinoma ◽  
Paranasal Sinuses ◽  
Poor Prognosis ◽  
Follicular Thyroid Carcinoma ◽  
Treatment Options ◽  
Distant Metastases ◽  
Differentiated Thyroid Carcinoma ◽  
Endoscopic Biopsy ◽  
Primary Lesion ◽  
Ethmoid Sinuses

AbstractThyroid carcinoma metastatic to the paranasal sinuses is extremely rare, with only 11 cases reported in the English and European literature. We report a case of metastatic follicular thyroid carcinoma to the clivus with extension into the sphenoid and posterior ethmoid sinuses. Pathological diagnosis was obtained using an intranasal endoscopic biopsy. As with our patient, metastatic thyroid carcinoma may present with symptoms related to distant metastases rather than the primary lesion. Distant metastases in differentiated thyroid carcinoma portends a poor prognosis. Our case of metastatic thyroid carcinoma to the paranasal sinuses is summarized in the context of the 11 additional cases, and treatment options are discussed.

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